December 2019 News
December 2019 Gwern.net newsletter with links on gene editing, the Replication Crisis, computer latency, and suffering; 4 book reviews, 2 opera/movie reviews, and 2 anime reviews.
December 2019’s Gwern.net newsletter is now out; previous, November 2019 (archives). This is a collation of links and summary of major changes, overlapping with my Changelog; brought to you by my donors on Patreon.
Writings
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On Correlation & Causality in the Social Sciences (see also my Replication Crisis bibliography)
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Gwern.net: Tufte-CSS margin notes support (glossing experiment—demonstrations in Folk-Music/Hydrocephalus/GoodReads/Internet Search Tips)
Media
Links
Genetics:
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Everything Is Heritable:
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“Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income”, et al 2019
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“Predicting educational achievement from genomic measures and socioeconomic status”, von et al 2019
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“Multivariable G-E interplay in the prediction of educational achievement”, et al 2019 (little GxE but much rGE: “the environment is genetic”)
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Recent Evolution:
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“A genome-wide Approximate Bayesian Computation approach suggests only limited numbers of soft sweeps in humans over the last 100,000 years”, et al 2019 (“∼80 sweeps in average across fifteen 1000G populations when assuming incomplete sweeps only and ∼140 selective sweeps in non-African populations when incorporating complete sweeps in our simulations”; wonder what they all do?)
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Engineering:
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“Extensive Mammalian Germline Genome Engineering”, et al 2019 ( media—“engineering 18 different loci using multiple genome engineering methods” in pigs; followup to et al 2017 )
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“Functional Oocytes Derived from Granulosa Cells”, et al 2019 (towards massive embryo selection/IES: cell → egg → mouse; “It got us thinking, what if we can utilize these granulosa cells? Since every egg has thousands of granulosa cells surrounding it, if we can induce them into pluripotent cells and turn those cells into oocytes, aren’t we killing two birds with one stone?”)
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He Jiankui sentenced to 3 years prison in secret trial for CRISPR editing of babies (2 associates sentenced to 2 & 1.5 years)
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AI:
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/r/AIDungeon: a subreddit for sharing AI Dungeon 2 games (a GPT-2-1.5b finetuned on RPG/text adventure stories eg. “My Musical Troupe of Orcs Uses Music to Advance Orc Rights”)
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Matters Of Scale:
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“Dota 2 with Large Scale Deep Reinforcement Learning”, et al 2019 ( blog; OpenAI final report on OA5, with many tips & tricks & glitches; cf. Tencent’s 1v1 MOBA paper: “To train one hero, we use 48 P40 GPU cards and 18,000 CPU cores.”)
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“Reformer: The Efficient Transformer”, et al 2019 ( blog; handling sequences up to length=64,000 on 1 GPU, which break GPT-2’s 1,024 context window bottleneck & would be great for MIDI music generation etc; see all the other alternatives as well)
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StyleGAN 2: “Analyzing and Improving the Image Quality of StyleGAN”, et al 2019 (eliminating the blob artifacts—this will make a nice upgrade for TWDNEv3)
Statistics/Meta-Science:
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“Comparing meta-analyses and preregistered multiple-laboratory replication projects”, et al 2019
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“The maddening saga of how an Alzheimer’s ‘cabal’ thwarted progress toward a cure for decades” (apropos of the latest blow to the amyloid hypothesis: amyloid does not even predict cognitive decline)
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“Snow Crystals”, Libbrecht 2019 (the complete monograph by the SnowCrystals.com man: the history of snow crystal studies, how to create & photography them, how they grow, how to simulate them…)
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“Do GRE scores help predict getting a physics Ph.D.? A comment on a paper by Miller et al”, 2019 (yes; the problems with the Miller GRE paper go well beyond just range restriction to conditioning on a collider and others)
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“Matthew Walker’s Why We Sleep Is Riddled with Scientific and Factual Errors”, Alexey Guzey (Andrew Gelman discussions: 1/2/3/4; apologist: “I study sleep…I think they are within reason and justified by the important message he is trying to convey.” cf. my Rosenthal review below)
Politics/religion:
Psychology/biology:
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“A Look Back at 2019: Progress Towards the Treatment of Aging as a Medical Condition”, Reason
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“A real-life Lord of the Flies: the troubling legacy of the Robbers Cave experiment” (manipulation & selective reporting)
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“Freedom From Fungus: Why Don’t Humans Have Chestnut-Style Blights and White Nose-Style Syndromes?”
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“Social context of shell acquisition in Coenobita clypeatus hermit crabs”, Rotjan et al 201014ya (hermit crab bubble sort for vacancy chains; SciAm)
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“Instinctive sleeping and resting postures: an anthropological and zoological approach to treatment of low back and joint pain”, Tetley 200024ya (idiosyncratic memoir/analysis of sleeping postures used by other primates/tribal societies)
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“Plumbing Stanley Kubrick”, Ian Watson 199925ya (writer’s memoir of years working on A.I. Artificial Intelligence & coping with Kubrick’s eccentricities)
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“Audiogenic reflex seizures in cats”, et al 2016 (not as amusing as YouTube videos would lead one to assume)
Technology:
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“href.cool: Links of the 2010s”, Kicks Condor (link compilation: selected subcultures, tech demos, viral content, and all things ’10s Internet—from the NSA to nyancat or SCP to space football)
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“Up and Then Down: The lives of elevators”, Paumgarten 200816ya (elevator safety, technology, and economics)
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Ben Carlin: circumnavigated the world in a failed amphibious jeep (1948–10195866ya)
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Why are modern computers so slow? “It’s the Latency, Stupid.”
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“Keyboard Latency”, Dan Luu (Measuring how slow modern keyboards are—they differ a lot)
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“Terminal Latency”, Dan Luu (How slow are terminal emulators? Kinda slow, and degrading badly under system load)
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“Web Bloat”, Dan Luu (Bloated webpages interact badly with latency inherent to the Internet & the HTML/browser architecture; the mentioned Google anecdote was YouTube)
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“Computer latency: 1977–402017”, Dan Luu; “Slow Software”, 2018; “Typing with pleasure”, Pavel Fatin (total latency—where all the latency in the stack comes from)
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“Local-first software: You own your data, in spite of the cloud”, 2019 (et al 2019 ; apps & clients which do all work locally but use CRDTss for distributed synchronization with your other devices, eliminating networking latency)
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“The Wheel of Reincarnation”, Norman Hardy (on 1968—“how many computers are in your computer?”)
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Christophe Plantin: mortgaged home to print the Plantin Polyglot Bible for the King of Spain to prove he wasn’t a heretic—but he was, a Familist; it is an elegant text, using multi-lingual dropcaps & a parallel layout of the 6 texts
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“The Floppy Toast”, Buttersafe (PEBKAC)
Economics:
Philosophy:
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“Two Arms and a Head: The Death of a Newly Paraplegic Philosopher”, Atreus 200816ya (review; memento mori—one of the saddest things I have ever read, this is the suicide note of a grad student crippled in a motorcycle accident; not entirely reasonable, but what is reasonable to expect of a man in unreasonable circumstances? Original forum thread; comments; cf. “How Do People Communicate Before Death? Insights into the little-studied realm of last words”/who by slow decay…)
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“In praise of self-deprecation”, Wisława Szymborska 197648ya; “The Kingfisher”, Mary Oliver 199034ya (House of Light); “Conversation with Jeanne”, Czesław Miłosz 198440ya (Provinces 199133ya)
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“Hypothermia” (how security researcher Moxie Marlinspike almost died of hypothermia & drowning in the San Francisco Bay while simply moving his catamaran boat to save docking fees)
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When a white horse is not a horse (Ceci n’est pas une pony.)
Books
Nonfiction:
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‘Small multiples’ show change across variables.
Visual Explanations: Images and Quantities, Evidence and Narrative, Tufte 1997 (less of a hodge-podge than Envisioning Information, Tufte walks through, as usual, graphs: how to show multiple versions of things, such as 4D data, on 2D paper? Key case studies are John Snow’s cholera maps of infections vs location vs time, the Challenger disaster’s obscuration of problems vs temperature over the course of Space Shuttle launches, stage magician diagrams of tricks, which illustrate change over time; Tufte then considers showing parallel versions which differ in some abstract dimension; then graphs which must show change in both space & time, such as sunspots or Saturn’s rings, representing Tufte’s usual concept of “small multiples”; in a final section, Tufte highlights favorite art pieces of his which are diagrammatic or symbolic in some sense akin to the foregoing chapters. As usual, a pleasure to read, and it furnished some examples for my page on rubrication too.)
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Surprisingly entertaining if not immediately useful. The Elements of Typographic Style (third edition), Bringhurst 200420ya (I decided to read this based on Rutter’s web version of it; Bringhurst is unexpectedly amusing—I wish I cared about anything as much as Bringhurst cares about typography. No comparison is too strong to condemn a typographical sin: editing fonts, for example makes it “easy for a designer or compositor with no regard for letters to squish them into cattle trains and ship them to the slaughter”—with another author, one would assume the Holocaust connotations were unintentional, but with Bringhurst… Like Rutter, there is a great of material on ratios and page layout which smacks of numerology, but that can be skipped easily, and the rest of the material is useful. The book itself is, of course, nice typographically, exemplifying the use of sidenotes, and although he surprisingly doesn’t cover it at length (like he does what seems like everything else), he even provides two nice examples of rubrication for my page.)
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A deeply dishonest harbinger of the Replication Crisis. Experimenter Effects In Behavioral Research, Rosenthal 197648ya (long review; consider also Rosenthal’s own description in “Citation Classic”)
Fiction:
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Well-intentioned but fatally self-undermined. String of Beads: Complete Poems of Princess Shikishi, Shikishi trans. Sato 199331ya (review)
Film/TV
Live-action:
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Rurouni Kenshin 201212ya/Rurouni Kenshin: Kyoto Inferno 2014/Rurouni Kenshin: The Legend Ends 2014 (review)
Animated:
Music
MLP:
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“Heartfire” (John Kenza; Compass Rose {2017}) [house]
Doujin:
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“Cute Swing” (Mihoney; {2019}) [house]