2016 News
This is the 2016 summary edition of the Gwern.net newsletter, summarizing the best of the monthly 2016 newsletters:
Previously: 2015.
Writings
Despite taking two long trips and some personal troubles (plumbing, an epic laptop failure, & law enforcement), 2016 was a much better year for my statistics & writing than 2015:
Adding metadata to an RNN for mimicking individual author style
Wikipedia articles on Genome-wide complex trait analysis (GCTA) & genetic correlations
“The Power of Twins: Revisiting Student’s Scottish Milk Experiment Example”
Genius Revisited: Critiquing the Value of High IQ Elementary Schools
Site traffic was healthy: 635,123 pageviews by 312,659 users.
Media
Overview
Continuing the 2015 trends, 2016 was a banner year for AI & genetics.
In AI, demonstrating the potential for rapid advance, AlphaGo went from low professional level as of October 2015 to world champion level, crushing Lee Sedol 4-1 with substantial margin, and just when everyone had forgotten, then a refined (presumably pure self-play) version of AlphaGo went 60-0 in blitz matches online with many of the top Go players (including Ke Jie). The translation RNNs finally made their long-awaited appearance in commercial production with Google Translate, making for the largest jump in translation quality in decades, bringing many translation pairs up to surprisingly high quality (even Japanese⟺English translations are now semi-comprehensible, as opposed to the status quo total gibberish); combined with the rapid progress in voice transcription and the surprising results of human-level lipreading, one can now imagine a NN-powered Babelfish (which, combined with HUDs, could be revolutionary for the deaf & hearing-impaired). Generative adversarial networks (GANs) remained a central topic of AI research, with better theoretical understanding (linking them to reinforcement learning), and many tweaks and incremental refinements increasing the size of feasible generated images (eg. StackGAN’s large bird/
In genetics, the growth of UK Biobank and the introduction of LD score regression & other summary-statistic-only methods continued driving large-scale results; the study of human genetic correlations made an absurd amount of progress in 2016, demonstrating shared genetic influences on countless phenotypic traits and pervasive intercorrelations of good traits and disease traits, respectively. Detecting recent human evolution has been difficult due to lack of ancient DNA to compare with, but the supply of that has grown steadily, permitting some specific examples to be nailed down, and a new method based on contemporary whole genomes may blow the area wide open as whole genomes have recently crossed the $1,380$1k2016 mark and in coming years, scientific projects & medical biobanks will shift over to whole genomes. Another possible field explosion is “genome synthesis”—I was astonished to learn that it is now feasible to synthesize from scratch entire chromosomes of arbitrary design, and that a human genome could potentially be synthesized for ~$1,379,667,467$1b2016, which would render totally obsolete any considerations of embryo selection/
Less cosmically, one of the big tech stories of 2016 was the rollout of consumer VR—successful but not epochal, clearly the (or at least, a) future of gaming but no killer app. Oculus had a rocky launch caused by its decision to launch prematurely, without motion controls, which the launch of HTC/
Links
Genetics:
Everything Is Heritable:
“Top 10 Replicated Findings From Behavioral Genetics”, et al2016
“The Genetics of Success: How Single-Nucleotide Polymorphisms Associated With Educational Attainment Relate to Life-Course Development”, et al2016; “Genome-wide association study of cognitive functions and educational attainment in UK Biobank (n = 112151)”, et al2016a; “Genome-wide association study identifies 74 [162] loci associated with educational attainment”, et al2016b; “Predicting educational achievement from DNA”, et al2016 (supplement; polygenic scores now predict 3.5% of intelligence, 7% of family SES, and 9% of education)
“Molecular genetic contributions to social deprivation and household income in UK Biobank (n = 112,151)”, et al2016 (correlation graph); “Genetic link between family socioeconomic status and children’s educational achievement estimated from genome-wide SNPs”, 2016
“Genome-wide association study of antisocial personality disorder”, et al2016 (GWAS hits on crime)
“Schizophrenia and subsequent neighborhood deprivation: revisiting the social drift hypothesis using population, twin and molecular genetic data”, et al2016 (good use of polygenic scores for confirmation)
“Ultra-rare disruptive and damaging mutations influence educational attainment in the general population”, et al2016; “Cognitive Performance Among Carriers of Pathogenic Copy Number Variants: Analysis of 152,000 UK Biobank Subjects”, et al2016
Pleiotropy:
“Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (n = 112151) and 24 GWAS consortia”, et al2016; “Detection and interpretation of shared genetic influences on 42 human traits”, et al2016; “An Atlas of Genetic Correlations across Human Diseases and Traits”, Bulik-et al2015; “Phenome-wide Heritability Analysis of the UK Biobank”, et al2016
“Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs”, Psychiatric Genomics 2013; “Analysis of shared heritability in common disorders of the brain”, et al2016; “Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders”, et al2016; “Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses”, et al2016a; “Association between stressful life events and psychotic experiences in adolescence: evidence for gene-environment correlations”, et al2016; “Associations between Polygenic Risk for Psychiatric Disorders and Substance Involvement”, et al2016
“Shared genetic aetiology of puberty timing between sexes and with health-related outcomes”, et al2015; “Physical and neurobehavioral determinants of reproductive onset and success”, et al2016
“The Causal Effects of Education on Health, Mortality, Cognition, Well-being, and Income in the UK Biobank”, et al2016b
“Educational attainment and personality are genetically intertwined”, et al2016
Recent Evolution:
Engineering:
“Improved CRISPR-Cas9: Safe and Effective?”: “High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects”/
“Rationally engineered Cas9 nucleases with improved specificity” “Introducing precise genetic modifications into human 3PN embryos by CRISPR/
Cas-mediated genome editing” , et al2016 (see also et al2015)“The Genome Project-Write”, et al2016 (media)
AI:
“Google’s Multilingual Neural Machine Translation System: Enabling Zero-Shot Translation”, et al2016; “Found in translation: More accurate, fluent sentences in Google Translate”
“Hybrid computing using a neural network with dynamic external memory”, et al2016 (blog); scaling to extremely large external memories: “Scaling Memory-Augmented Neural Networks with Sparse Reads and Writes”, et al2016
“Progressive Neural Networks”, et al2016a; “Sim-to-Real Robot Learning from Pixels with Progressive Nets”, et al2016b; “Overcoming catastrophic forgetting in neural networks”, et al2016 (see also “Actor-Mimic: Deep Multitask and Transfer Reinforcement Learning”, et al2015)
“Decoupled Neural Interfaces using Synthetic Gradients”, et al2016 (DeepMind explainer; potentially allows for extreme parallelization of neural nets across GPUs)
“Outrageously large neural networks: the sparsely-gated mixture-of-experts layer”, et al2016
“One-shot Learning with Memory-Augmented Neural Networks”, et al2016
“Programming with a Differentiable Forth Interpreter”, et al2016; “DeepCoder: Learning to Write Programs”, et al2016; “Learning to superoptimize programs”, et al2016; DeepMath/
“HolStep: A Machine Learning Dataset for Higher-order Logic Theorem Proving”, et al2016 (continuing the AlphaGo theme of tree search+NN heuristics; see also “Deep Learning for Real-Time Atari Game Play Using Offline Monte-Carlo Tree Search Planning”, et al2014) “Achieving Human Parity in Conversational Speech Recognition”, et al2016
“Lip Reading Sentences in the Wild”, et al2016 (video); “LipNet: Sentence-level Lipreading”, et al2016 (video)
reinforcement learning:
“Mastering the game of Go with deep neural networks and tree search”, et al2016
“Neural architecture search with reinforcement learning”, 2016; “Designing Neural Network Architectures using Reinforcement Learning”, et al2016; “Learning to reinforcement learn”, et al2016
“Value Iteration Networks”, et al2016; “The Predictron: End-To-End Learning and Planning”, et al2016
“Unifying Count-Based Exploration and Intrinsic Motivation”, et al2016 (Video)
“Asynchronous Methods for Deep Reinforcement Learning (A3C)”, et al2016
“Reinforcement Learning with Unsupervised Auxiliary Tasks”, et al2016; “Loss is Its Own Reward: Self-supervision for Reinforcement Learning”, et al2016
“Learning Hand-Eye Coordination for Robotic Grasping with Deep Learning and Large-Scale Data Collection”, et al2016 (video); “Deep Reinforcement Learning for Robotic Manipulation”, et al2016 (video; blog)
Statistics/
“When Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility Crisis”, 2016
“Online Controlled Experiments: Introduction, Learnings, and Humbling Statistics”, 2012
“Underreporting in Psychology Experiments: Evidence From a Study Registry”, et al2015 (previously: et al2014)
“Peer review: Troubled from the start”; “Saving Science: Science isn’t self-correcting, it’s self-destructing. To save the enterprise, scientists must come out of the lab and into the real world.”
“Generalized Network Psychometrics: Combining Network and Latent Variable Models”, et al2016
“Statistically Controlling for Confounding Constructs Is Harder than You Think”, 2016 (Even a structural equation model (SEM) which explicitly incorporates measurement error may still have enough leakage to render ‘controlling’ misleading. See also 1936/
1942/ 1965.)
Psychology:
“When Lightning Strikes Twice: Profoundly Gifted, Profoundly Accomplished”, et al2016; “Ann Roe’s scientists: original published papers”; “From Terman to Today: A Century of Findings on Intellectual Precocity”, 2016
“Heads or tails: the impact of a coin toss on major life decisions and subsequent happiness”, 2020
“A Meta-Analysis of Blood Glucose Effects on Human Decision Making”, 2016; “Is Ego-Depletion a Replicable Effect? A Forensic Meta-Analysis of 165 Ego Depletion Articles”
Do Portia spiders have a mind? (commentary on Portia spiders)
“Childhood forecasting of a small segment of the population with large economic burden”, et al2016 (“Figure 4: The Big Footprint of Multiple-High-Cost-Users”; for the genetic version, see et al2016); “Clustering of health, crime and social-welfare inequality in 4 million citizens from two nations”, Richmond-et al2020
Psychedelics & psychological well-being (media):
“The paradoxical psychological effects of lysergic acid diethylamide (LSD)”, Carhart-et al2016
Biology:
“Aldehyde-stabilized cryopreservation”, 2015 wins the Small Mammal Brain Preservation Prize by passing their evaluation (commentary)
Politics/
“The Strategic Consequences of Chinese Racism: A Strategic Asymmetry for the United States”, 2013
“Okhrana: The Paris Operations of the Russian Imperial Police”
“Once Upon a Jihad” /
“Experiencing Ecstasy: How Bad It Is to Be 20 Years Old” / “My Year in San Francisco’s $2 Million Secret Society Startup” “How a detachment of U.S. Army soldiers smoked out the original Ku Klux Klan”
“At Tampa Bay farm-to-table restaurants, you’re being fed fiction” (Qui vult decipi decipiatur.)
Technology:
“The Slow Winter”, Mickens
“DDoSCoin: Cryptocurrency with a Malicious Proof-of-Work”, Wustrow & Vander2016
“Beaver: A Decentralized Anonymous Marketplace with Secure Reputation”, et al2016
“The Distribution of Users’ Computer Skills: Worse Than You Think”
Economics:
“Typhoid Fever, Water Quality, and Human Capital Formation”, et al2016; “When It Rains It Pours: The Long-run Economic Impacts of Salt Iodization in the United States”, et al2016; “The Production of Human Capital in Developed Countries: Evidence from 196 Randomized Field Experiments”, 2016
Abuse of ‘arbitration’ clauses in international trade treaties to escape criminal liability
“The View from Above: Applications of Satellite Data in Economics”, 2016
“Adam Smith, Watch Prices, and the Industrial Revolution”, 2016 (commentary)
“Elephants and Mammoths: Can Ice Ivory Save Blood Ivory?”, 2015
“The Case Against Everyone’s Favorite Tax Break: The Mortgage Interest Deduction”
Philosophy:
“Logical Induction”, et al2016
“Towards an integration of deep learning and neuroscience”, et al2016
“Probing the Improbable: Methodological Challenges for Risks with Low Probabilities and High Stakes”, et al2008
Fiction:
There Is No Anti-Memetics Division, by Sam Hughes
“Suminoe Beach”, by Kuramochi Chitose
“Poverty”, by Moon Byung-ran
“Design”, by Robert Frost
Books
Nonfiction:
Don’t Sleep, There Are Snakes: Life and Language in the Amazonian Jungle, Everett 200916ya (on the Pirahã people)
The Sports Gene, Epstein
Fortune’s Formula, 2005
The Genius Factory, 2005
Fiction:
Poems of Gerard Manley Hopkins, Gerard Manley Hopkins
TV/movies
Nonfiction movies:
Fiction:
Anime: