May 2016 News
This is the May 2016 edition of the Gwern.net newsletter; previous, April 2016. This is a collation of links and summary of major changes, overlapping with Changelog; brought to you by my donors on Patreon.
Writings
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Wikipedia article on Genome-wide complex trait analysis (GCTA)
Media
Links
Genetics:
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Everything Is Heritable:
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“Genome-wide association study identifies 74 [162] loci associated with educational attainment”, et al 2016
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“LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis”, et al 2016 (Web interface to scores of GWAS results, allowing combined inference over them all: LD Hub. Gets around privacy & scaling problems by using, not GCTA, but LD regression which only needs summary statistics. LD score regression is definitely the wave of the future. GCTA was king for a few years, but the inability to use summary data is killing it; in the modern context of a thousand different funding sources, ‘medical ethics’, & empire building driving countless genetic silos, a method must be able to work on just summary statistics if it’s to have any real uptake and get n into the hundreds of thousands.)
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“Detection and interpretation of shared genetic influences on 42 human traits”, et al 2016
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“An Atlas of Genetic Correlations across Human Diseases and Traits”, Bulik-et al 2015
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“Genetic contributions to self-reported tiredness”, et al 2016 (GCTA estimate is not too impressive, but the pleiotropy is interesting. What do you get when you sum a lot of weakly genetically-correlated variables? A giant difference.)
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Recent Evolution:
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“Detection of human adaptation during the past 2,000 years”, et al 2016
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“Population structure of UK Biobank and ancient Eurasians reveals adaptation at genes influencing blood pressure”, et al 2016 (Biobank—the gift that keeps on giving. The genetic revolution continues.)
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“Quantitative Genetics in the Postmodern Family of the Donor Sibling Registry”, Lee 201311ya (maternal selection of sperm donors for height increases offspring height as much as predicted by heritability estimates+breeder’s equation)
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“Genetic evidence for natural selection in humans in the contemporary United States”, 2016
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“Schizophrenia and subsequent neighborhood deprivation: revisiting the social drift hypothesis using population, twin and molecular genetic data”, et al 2016 (good use of polygenic scores for confirmation)
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“The phenotypic legacy of admixture between modern humans and Neandertals”, et al 2016
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“The MC1R Gene and Youthful Looks”, et al 2016
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“Molecular genetic contributions to self-rated health”, et al 2016 (I love how you can ask people something as super-vague as ‘do you think you’re in good health’ and you still get noticeable heritabilities and disease-related hits with a big enough dataset like Biobank.)
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Engineering:
Politics/religion:
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“Gods and Gamma” on “‘God has sent me to you’: Right temporal epilepsy, left prefrontal psychosis”, 2016 (an EEG recording of a messianic religious conversion experience!)
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“At Tampa Bay farm-to-table restaurants, you’re being fed fiction” (Qui vult decipi decipiatur.)
AI:
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“One-shot Learning with Memory-Augmented Neural Networks”, et al 2016
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“Programming with a Differentiable Forth Interpreter”, et al 2016
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“FractalNet: Ultra-Deep Neural Networks without Residuals”, 2016
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“Artistic style transfer for videos”, et al 2016 ( video demonstration; I particularly like the inkwash-style footage at the end)
Statistics/meta-science:
Psychology/biology:
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“When Lightning Strikes Twice: Profoundly Gifted, Profoundly Accomplished”, et al 2016 (Intelligence increases success as high as it can be measured; diminishing returns ≠ zero returns… This replicates the SMPY results in a separate TIP sample.)
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“Dogs Test Drug [rapamycin] Aimed at Humans’ Biggest Killer: Age”
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“Could a neuroscientist understand a microprocessor?”, 2016 (amusing followup to “Can a biologist fix a radio?”, Lazebnik 200222ya; itself a response to 1961)
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“A Second Year of Spaced Repetition Software in the Classroom”
Technology:
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“Beaver: A Decentralized Anonymous Marketplace with Secure Reputation”, et al 2016
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“The Mastermind” (In depth series about international criminal mastermind Paul Le Roux who ran his group online while ordering hits on employees using mercenaries and smuggling drug until he is captured and becomes a USG asset to entrap his employees and assist who knows what covert operations. Oh, and he created TrueCrypt. His story is even wilder than Ross Ulbricht’s.)
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“How Harry Brearley’s Stubborn Insistence Gave Us Knives That Don’t Rust” (see also multiple discovery)
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“Have I Been Pwned?” (service for looking up whether email addresses are linked to past hacks, and subscribing to alerts)
Economics:
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“Going for the Gold: The Economics of the Olympics”, 2016 (The case against the Olympics. Too late for Brazil, though, but others can learn from that debacle.)
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“Results of an international drug testing service for cryptomarket users”, et al 2016
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“Railway Paradise: How a Fine-Dining Empire Made the Southwest Palatable to Outsiders” (statistical discrimination vs taste discrimination: profiting from sexism)
Fiction:
Books
Nonfiction:
Fiction:
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Poems of Gerard Manley Hopkins, by Gerard Manley Hopkins (review)
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“CORDYCEPS: Too clever for their own good” (SF/horror humor novella on overthinking things; early chapters are best in exploring acausal & amnesiac reasoning, somewhat like Utsuro no Hako to Zero no Maria, but goes on perhaps a bit too long and explains too much)
Fanfiction:
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Significant Digits (Harry Potter and the Methods of Rationality: sequel intended to conclude the story; more action-focused with a literary bent, and much less didactic/“author tract” and Harry-focused than MoR. Highly recommended for anyone who liked MoR.)
Film/TV
Live-action:
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Father Goose (peculiar Cary Grant WWII comedy-drama; it’s unusual to see Grant cast as a misanthropic drunkard and the movie can’t quite decide whether to be deadly serious or comedic, but most of the comedic beats are highly predictable)
Anime:
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Short Peace ([/review/anime#short-peace))
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Death Parade (expansion of Death Billiards, as an episodic series; stories remain a bit heavily focused on suicide and murder, but while the dark background story arc ultimately ends in a whimper, the main story arc ends in an emotionally satisfying way)
Music
Touhou:
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“無間の鐘 ~ Infinite Nightmare” (xi-on feat.oz_hiro; Mapleaves {C89}) [jazz]
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“Zen~然~ -hybrid remix-” (NSY feat. 茶太; LessExtra {C89}) [electronic]
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“Monolog -Remix-” (Pastry; ‘Plusieurs Fleur’ {K8}) [electronic/classical]
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“金木犀” (Ringing Volcano; Shinmyômaru’s Little Adventures {C89}) [folk]
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“露時雨” (Ringing Volcano; Shinmyômaru’s Little Adventures {C89}) [folk]
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“Like the geese” (Escarmew; Secret Sealing Moratorium {K201212ya}) [Celtic]
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“This apple is bad” (thj.quartet; Jazz Funk Live! {C89}) [jazz]
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“Tea Funk” (thj.quartet; Jazz Funk Live! {C89}) [jazz]
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“俯瞰する蒼然暮色” (とらっしゅ; 秘封サウンドスケープ集III Phantasma Sound Archive No.53 {TK10}) [orchestral rock]
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“還流大洋の原点へ” (とらっしゅ; 秘封サウンドスケープ集III Phantasma Sound Archive No.53 {TK10}) [orchestral rock]
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“飛来する蓬莱物質” (とらっしゅ; 秘封サウンドスケープ集III Phantasma Sound Archive No.53 {TK10}) [orchestral rock]
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“アンラクト・フィリング” (とらっしゅ; 秘封サウンドスケープ集III Phantasma Sound Archive No.53 {TK10}) [orchestral rock]
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“Your World” (はちみつれもんxAftergrow; TOUHOU SIX STRING 02.封 {C89}) [instrumental rock]
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“Month of Flowers” (あいざわ feat. ゆーな; TOUHOU SIX STRING 02.封 {C89}) [Jpop/ballad]
Vocaloid:
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“Autumn Beat” (Miku; adidkh; PRE:Days EP {2016}) [electronic]
Doujin:
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“Once Upon A Love” (P*Light; Colorful Palette {C89}) [hardcore]