- See Also
- Gwern
-
Links
- “DNAm Aging Biomarkers Are Responsive: Insights from 51 Longevity Interventional Studies in Humans”, Sehgal et al 2024
- “Metformin Decelerates Aging Clock in Male Monkeys”, Yang et al 2024
- “Is Target-Based Drug Discovery Efficient? Discovery and ‘Off-Target’ Mechanisms of All Drugs”, Sadri 2023
- “Evaluation of Out-Of-Pocket Costs and Treatment Intensification With an SGLT2 Inhibitor or GLP-1 RA in Patients With Type 2 Diabetes & Cardiovascular Disease”, Luo et al 2023
- “An Epigenetic Aging Analysis of Randomized Metformin and Weight Loss Interventions in Overweight Postmenopausal Breast Cancer Survivors”, Nwanaji-Enwerem et al 2021
- “Metformin Treatment of Diverse Caenorhabditis Species Reveals the Importance of Genetic Background in Longevity and Healthspan Extension Outcomes”, Onken et al 2021
- “Nutritional Reprogramming of Mouse Liver Proteome Is Dampened by Metformin, Resveratrol, and Rapamycin”, Couteur et al 2021
- “Effect of Metformin and Lifestyle Interventions on Mortality in the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study”, Lee et al 2021b
- “A Collective Analysis of Lifespan-Extending Compounds in Diverse Model Organisms, and of Species Whose Lifespan Can Be Extended the Most by the Application of Compounds”, Berkel & Cacan 2021
- “The Economic Value of Targeting Aging”, Scott et al 2021
- “The Quest to Slow Ageing through Drug Discovery”, Partridge et al 2020
- “Metformin and Aging: A Review”, Glossmann & Lutz 2019
- “Metformin Inhibits Mitochondrial Adaptations to Aerobic Exercise Training in Older Adults”, Konopka 2018
- “Metformin Reduces All-Cause Mortality and Diseases of Ageing Independent of Its Effect on Diabetes Control: A Systematic Review and Meta-Analysis”, Campbell et al 2017
- “Metformin As a Tool to Target Aging”, Barzilai et al 2016
- “Metformin: Do We Finally Have an Anti-Aging Drug?”, Anisimov 2013
- “Reappraisal of Metformin Efficacy in the Treatment of Type 2 Diabetes: a Meta-Analysis of Randomized Controlled Trials”, Boussageon et al 2012
- “Metformin in Obesity, Cancer and Aging: Addressing Controversies”, Berstein 2012
- “Metformin As a Geroprotector”, Bulterijs 2011
- “Dr. Nir Barzilai on the TAME Study”
- “Metformin in Longevity Study (MILES)”
- “Cardiovascular Outcomes in Trials of Oral Diabetes Medications: A Systematic Review Acute Coronary Syndromes”
- “Metformin Dosage Guide + Max Dose, Adjustments”
- “Metformin Side Effects: Common, Severe, Long Term”
- “Metformin (Oral Route) Proper Use”
- “Not Found”
- “Metformin and Fatal Lactic Acidosis”
- “Anti-Ageing Pill Pushed As Bona Fide Drug: Regulators Asked to Consider Ageing a Treatable Condition”
- “‘I Think There’s No Doubt That Insulin Is Pro-Cancer”, Watson Says, with respect to the Link between Obesity, Diabetes and Cancer. “It’s As Good a Hypothesis As We Have Now.’ Watson Takes Metformin for Cancer Prevention; among Its Many Effects, Metformin Works to Lower Insulin Levels.”
- “The Man Who Wants to Beat Back Aging: Nir Barzilai Hopes to Persuade FDA to Bless the Proposed Anti-Aging Trial, Which Is Unconventional in Its Goals and Design.”
- “Forget the Blood of Teens. Metformin Promises to Extend Life for a Nickel a Pill”
- Wikipedia
- Miscellaneous
- Bibliography
See Also
Gwern
“Life Extension Cost-Benefits”, Gwern 2015
Links
“DNAm Aging Biomarkers Are Responsive: Insights from 51 Longevity Interventional Studies in Humans”, Sehgal et al 2024
DNAm aging biomarkers are responsive: Insights from 51 longevity interventional studies in humans
“Metformin Decelerates Aging Clock in Male Monkeys”, Yang et al 2024
“Is Target-Based Drug Discovery Efficient? Discovery and ‘Off-Target’ Mechanisms of All Drugs”, Sadri 2023
Is Target-Based Drug Discovery Efficient? Discovery and ‘Off-Target’ Mechanisms of All Drugs
“Evaluation of Out-Of-Pocket Costs and Treatment Intensification With an SGLT2 Inhibitor or GLP-1 RA in Patients With Type 2 Diabetes & Cardiovascular Disease”, Luo et al 2023
“An Epigenetic Aging Analysis of Randomized Metformin and Weight Loss Interventions in Overweight Postmenopausal Breast Cancer Survivors”, Nwanaji-Enwerem et al 2021
“Metformin Treatment of Diverse Caenorhabditis Species Reveals the Importance of Genetic Background in Longevity and Healthspan Extension Outcomes”, Onken et al 2021
“Nutritional Reprogramming of Mouse Liver Proteome Is Dampened by Metformin, Resveratrol, and Rapamycin”, Couteur et al 2021
“Effect of Metformin and Lifestyle Interventions on Mortality in the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study”, Lee et al 2021b
“A Collective Analysis of Lifespan-Extending Compounds in Diverse Model Organisms, and of Species Whose Lifespan Can Be Extended the Most by the Application of Compounds”, Berkel & Cacan 2021
“The Economic Value of Targeting Aging”, Scott et al 2021
“The Quest to Slow Ageing through Drug Discovery”, Partridge et al 2020
“Metformin and Aging: A Review”, Glossmann & Lutz 2019
“Metformin Inhibits Mitochondrial Adaptations to Aerobic Exercise Training in Older Adults”, Konopka 2018
Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults
“Metformin Reduces All-Cause Mortality and Diseases of Ageing Independent of Its Effect on Diabetes Control: A Systematic Review and Meta-Analysis”, Campbell et al 2017
“Metformin As a Tool to Target Aging”, Barzilai et al 2016
“Metformin: Do We Finally Have an Anti-Aging Drug?”, Anisimov 2013
“Reappraisal of Metformin Efficacy in the Treatment of Type 2 Diabetes: a Meta-Analysis of Randomized Controlled Trials”, Boussageon et al 2012
“Metformin in Obesity, Cancer and Aging: Addressing Controversies”, Berstein 2012
Metformin in obesity, cancer and aging: addressing controversies
“Metformin As a Geroprotector”, Bulterijs 2011
“Dr. Nir Barzilai on the TAME Study”
“Metformin in Longevity Study (MILES)”
“Cardiovascular Outcomes in Trials of Oral Diabetes Medications: A Systematic Review Acute Coronary Syndromes”
View External Link:
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/414585
“Metformin Dosage Guide + Max Dose, Adjustments”
“Metformin Side Effects: Common, Severe, Long Term”
“Metformin (Oral Route) Proper Use”
“Not Found”
“Metformin and Fatal Lactic Acidosis”
“Anti-Ageing Pill Pushed As Bona Fide Drug: Regulators Asked to Consider Ageing a Treatable Condition”
Anti-ageing pill pushed as bona fide drug: Regulators asked to consider ageing a treatable condition
“‘I Think There’s No Doubt That Insulin Is Pro-Cancer”, Watson Says, with respect to the Link between Obesity, Diabetes and Cancer. “It’s As Good a Hypothesis As We Have Now.’ Watson Takes Metformin for Cancer Prevention; among Its Many Effects, Metformin Works to Lower Insulin Levels.”
“The Man Who Wants to Beat Back Aging: Nir Barzilai Hopes to Persuade FDA to Bless the Proposed Anti-Aging Trial, Which Is Unconventional in Its Goals and Design.”
“Forget the Blood of Teens. Metformin Promises to Extend Life for a Nickel a Pill”
Forget the Blood of Teens. Metformin Promises to Extend Life for a Nickel a Pill:
View External Link:
https://www.wired.com/story/this-pill-promises-to-extend-life-for-a-nickel-a-pop
Wikipedia
Miscellaneous
Bibliography
-
2023-sadri.pdf: “Is Target-Based Drug Discovery Efficient? Discovery and ‘Off-Target’ Mechanisms of All Drugs”, -
https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-021-01218-y: “An Epigenetic Aging Analysis of Randomized Metformin and Weight Loss Interventions in Overweight Postmenopausal Breast Cancer Survivors”,