Bibliography (126):

1. When Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility Crisis

2. How were new medicines discovered?

3. The discovery of first-in-class drugs: origins and evolution

4. https://pubs.acs.org/doi/suppl/10.1021/acs.jmedchem.2c01737/suppl_file/jm2c01737_si_001.pdf#page=135

5. History of the Design of Captopril and Related Inhibitors of Angiotensin Converting Enzyme

6. https://pubs.acs.org/doi/suppl/10.1021/acs.jmedchem.2c01737/suppl_file/jm2c01737_si_001.pdf

7. https://pubs.acs.org/doi/suppl/10.1021/acs.jmedchem.2c01737/suppl_file/jm2c01737_si_003.pdf

8. What the Scientists Who Pioneered Weight-Loss Drugs Want You to Know

9. The topology of drug-target interaction networks: implicit dependence on drug properties and target families

10. https://www.science.org/content/blog-post/target-based-drug-discovery-waste-time

11. Artificial intelligence in drug discovery: what is realistic, what are illusions? Part 1: Ways to make an impact, and why we are not there yet: Quality is more important than speed and cost in drug discovery

12. How to improve R&D productivity: the pharmaceutical industry’s grand challenge

13. Look back in anger—what clinical studies tell us about preclinical work

14. Translating animal research into clinical benefit

15. The Major Role of Clinicians in the Discovery of Off-Label Drug Therapies

16. Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials

17. Wikipedia Bibliography:

    1. https://en.wikipedia.org/wiki/Target-based_drug_discovery  :

       https://en.wikipedia.org/wiki/Target-based_drug_discovery

    2. https://en.wikipedia.org/wiki/Small-molecule_drugs  :

       https://en.wikipedia.org/wiki/Small-molecule_drugs

    3. Systematic review

    4. https://en.wikipedia.org/wiki/Captopril  :

       https://en.wikipedia.org/wiki/Captopril

    5. https://en.wikipedia.org/wiki/Discovery_and_development_of_ACE_inhibitors  :

       https://en.wikipedia.org/wiki/Discovery_and_development_of_ACE_inhibitors

    6. https://en.wikipedia.org/wiki/Y_S_Bakhle  :

       https://en.wikipedia.org/wiki/Y_S_Bakhle

    7. https://en.wikipedia.org/wiki/Angiotensin-converting_enzyme  :

       https://en.wikipedia.org/wiki/Angiotensin-converting_enzyme

    8. https://en.wikipedia.org/wiki/Bothrops_jararaca  :

       https://en.wikipedia.org/wiki/Bothrops_jararaca

    9. https://en.wikipedia.org/wiki/Ileum  :

       https://en.wikipedia.org/wiki/Ileum

    10. https://en.wikipedia.org/wiki/Antihypertensive_drug  :

        https://en.wikipedia.org/wiki/Antihypertensive_drug

    11. https://en.wikipedia.org/wiki/Angiotensin#Angiotensin_I  :

        https://en.wikipedia.org/wiki/Angiotensin#Angiotensin_I

    12. https://en.wikipedia.org/wiki/Bradykinin  :

        https://en.wikipedia.org/wiki/Bradykinin

    13. https://en.wikipedia.org/wiki/Smooth_muscle  :

        https://en.wikipedia.org/wiki/Smooth_muscle

    14. https://en.wikipedia.org/wiki/Saquinavir  :

        https://en.wikipedia.org/wiki/Saquinavir

    15. https://en.wikipedia.org/wiki/Isoprenaline  :

        https://en.wikipedia.org/wiki/Isoprenaline

    16. Propranolol

    17. https://en.wikipedia.org/wiki/Cimetidine  :

        https://en.wikipedia.org/wiki/Cimetidine

    18. https://en.wikipedia.org/wiki/Ethosuximide  :

        https://en.wikipedia.org/wiki/Ethosuximide

    19. https://en.wikipedia.org/wiki/Purine_analogs  :

        https://en.wikipedia.org/wiki/Purine_analogs

    20. https://en.wikipedia.org/wiki/Ciclosporin  :

        https://en.wikipedia.org/wiki/Ciclosporin

    21. https://en.wikipedia.org/wiki/Pentamidine  :

        https://en.wikipedia.org/wiki/Pentamidine

    22. https://en.wikipedia.org/wiki/Omeprazole  :

        https://en.wikipedia.org/wiki/Omeprazole

    23. https://en.wikipedia.org/wiki/Propofol  :

        https://en.wikipedia.org/wiki/Propofol

    24. Paclitaxel

    25. https://en.wikipedia.org/wiki/Topotecan  :

        https://en.wikipedia.org/wiki/Topotecan

    26. https://en.wikipedia.org/wiki/Ivermectin  :

        https://en.wikipedia.org/wiki/Ivermectin

    27. https://en.wikipedia.org/wiki/Topiramate  :

        https://en.wikipedia.org/wiki/Topiramate

    28. https://en.wikipedia.org/wiki/Leflunomide  :

        https://en.wikipedia.org/wiki/Leflunomide

    29. Sirolimus

    30. https://en.wikipedia.org/wiki/Ezetimibe  :

        https://en.wikipedia.org/wiki/Ezetimibe

    31. https://en.wikipedia.org/wiki/Cinacalcet  :

        https://en.wikipedia.org/wiki/Cinacalcet

    32. https://en.wikipedia.org/wiki/Tecovirimat  :

        https://en.wikipedia.org/wiki/Tecovirimat

    33. https://en.wikipedia.org/wiki/Tetracycline_antibiotics  :

        https://en.wikipedia.org/wiki/Tetracycline_antibiotics

    34. https://en.wikipedia.org/wiki/Penicillin  :

        https://en.wikipedia.org/wiki/Penicillin

    35. https://en.wikipedia.org/wiki/Cephalosporin  :

        https://en.wikipedia.org/wiki/Cephalosporin

    36. https://en.wikipedia.org/wiki/Pyrimethamine  :

        https://en.wikipedia.org/wiki/Pyrimethamine

    37. https://en.wikipedia.org/wiki/Chloroquine  :

        https://en.wikipedia.org/wiki/Chloroquine

    38. https://en.wikipedia.org/wiki/Vancomycin  :

        https://en.wikipedia.org/wiki/Vancomycin

    39. https://en.wikipedia.org/wiki/Rifampicin  :

        https://en.wikipedia.org/wiki/Rifampicin

    40. https://en.wikipedia.org/wiki/Clavulanic_acid  :

        https://en.wikipedia.org/wiki/Clavulanic_acid

    41. https://en.wikipedia.org/wiki/Pretomanid  :

        https://en.wikipedia.org/wiki/Pretomanid

    42. https://en.wikipedia.org/wiki/Retapamulin  :

        https://en.wikipedia.org/wiki/Retapamulin

    43. https://en.wikipedia.org/wiki/Lefamulin  :

        https://en.wikipedia.org/wiki/Lefamulin

    44. https://en.wikipedia.org/wiki/Spinosad  :

        https://en.wikipedia.org/wiki/Spinosad

    45. https://en.wikipedia.org/wiki/Bedaquiline  :

        https://en.wikipedia.org/wiki/Bedaquiline

    46. Lidocaine

    47. Amphetamine

    48. https://en.wikipedia.org/wiki/Cromoglicic_acid  :

        https://en.wikipedia.org/wiki/Cromoglicic_acid

    49. https://en.wikipedia.org/wiki/Bisacodyl  :

        https://en.wikipedia.org/wiki/Bisacodyl

    50. https://en.wikipedia.org/wiki/Ingenol_mebutate  :

        https://en.wikipedia.org/wiki/Ingenol_mebutate

    51. https://en.wikipedia.org/wiki/Bremelanotide  :

        https://en.wikipedia.org/wiki/Bremelanotide

    52. Bacitracin

    53. https://en.wikipedia.org/wiki/Ticlopidine  :

        https://en.wikipedia.org/wiki/Ticlopidine

    54. https://en.wikipedia.org/wiki/Valproate  :

        https://en.wikipedia.org/wiki/Valproate

    55. https://en.wikipedia.org/wiki/Warfarin  :

        https://en.wikipedia.org/wiki/Warfarin

    56. https://en.wikipedia.org/wiki/Meprobamate  :

        https://en.wikipedia.org/wiki/Meprobamate

    57. https://en.wikipedia.org/wiki/Vinca_alkaloid  :

        https://en.wikipedia.org/wiki/Vinca_alkaloid

    58. https://en.wikipedia.org/wiki/Dipyridamole  :

        https://en.wikipedia.org/wiki/Dipyridamole

    59. https://en.wikipedia.org/wiki/Diazoxide  :

        https://en.wikipedia.org/wiki/Diazoxide

    60. https://en.wikipedia.org/wiki/Cisplatin  :

        https://en.wikipedia.org/wiki/Cisplatin

    61. https://en.wikipedia.org/wiki/Etomidate  :

        https://en.wikipedia.org/wiki/Etomidate

    62. https://en.wikipedia.org/wiki/Naftifine  :

        https://en.wikipedia.org/wiki/Naftifine

    63. https://en.wikipedia.org/wiki/Glatiramer_acetate  :

        https://en.wikipedia.org/wiki/Glatiramer_acetate

    64. https://en.wikipedia.org/wiki/Imiquimod  :

        https://en.wikipedia.org/wiki/Imiquimod

    65. https://en.wikipedia.org/wiki/Thiazolidinedione  :

        https://en.wikipedia.org/wiki/Thiazolidinedione

    66. https://en.wikipedia.org/wiki/Levetiracetam  :

        https://en.wikipedia.org/wiki/Levetiracetam

    67. Piracetam

    68. https://en.wikipedia.org/wiki/Dapagliflozin  :

        https://en.wikipedia.org/wiki/Dapagliflozin

    69. https://en.wikipedia.org/wiki/Empagliflozin  :

        https://en.wikipedia.org/wiki/Empagliflozin

    70. https://en.wikipedia.org/wiki/Chlorpromazine  :

        https://en.wikipedia.org/wiki/Chlorpromazine

    71. https://en.wikipedia.org/wiki/Antipsychotic  :

        https://en.wikipedia.org/wiki/Antipsychotic

    72. https://en.wikipedia.org/wiki/Imipramine  :

        https://en.wikipedia.org/wiki/Imipramine

    73. https://en.wikipedia.org/wiki/Iproniazid  :

        https://en.wikipedia.org/wiki/Iproniazid

    74. Antidepressant

    75. Paracetamol

    76. https://en.wikipedia.org/wiki/Corticosteroid  :

        https://en.wikipedia.org/wiki/Corticosteroid

    77. https://en.wikipedia.org/wiki/Disulfiram  :

        https://en.wikipedia.org/wiki/Disulfiram

    78. https://en.wikipedia.org/wiki/Diuretic  :

        https://en.wikipedia.org/wiki/Diuretic

    79. https://en.wikipedia.org/wiki/Diabetes  :

        https://en.wikipedia.org/wiki/Diabetes

    80. https://en.wikipedia.org/wiki/Methyldopa  :

        https://en.wikipedia.org/wiki/Methyldopa

    81. Minoxidil

    82. https://en.wikipedia.org/wiki/Flibanserin  :

        https://en.wikipedia.org/wiki/Flibanserin

    83. https://en.wikipedia.org/wiki/Gemfibrozil  :

        https://en.wikipedia.org/wiki/Gemfibrozil

    84. https://en.wikipedia.org/wiki/Nabilone  :

        https://en.wikipedia.org/wiki/Nabilone

    85. https://en.wikipedia.org/wiki/Anagrelide  :

        https://en.wikipedia.org/wiki/Anagrelide

    86. https://en.wikipedia.org/wiki/Sildenafil  :

        https://en.wikipedia.org/wiki/Sildenafil

    87. https://en.wikipedia.org/wiki/Azelaic_acid  :

        https://en.wikipedia.org/wiki/Azelaic_acid

    88. https://en.wikipedia.org/wiki/Hydroquinone  :

        https://en.wikipedia.org/wiki/Hydroquinone

    89. https://en.wikipedia.org/wiki/Memantine  :

        https://en.wikipedia.org/wiki/Memantine

    90. Metformin

    91. https://en.wikipedia.org/wiki/Digoxin  :

        https://en.wikipedia.org/wiki/Digoxin

    92. https://en.wikipedia.org/wiki/Artemether  :

        https://en.wikipedia.org/wiki/Artemether

    93. https://en.wikipedia.org/wiki/Podophyllotoxin  :

        https://en.wikipedia.org/wiki/Podophyllotoxin

    94. https://en.wikipedia.org/wiki/Fingolimod  :

        https://en.wikipedia.org/wiki/Fingolimod

    95. https://en.wikipedia.org/wiki/Eribulin  :

        https://en.wikipedia.org/wiki/Eribulin

    96. https://en.wikipedia.org/wiki/Sarecycline  :

        https://en.wikipedia.org/wiki/Sarecycline

    97. https://en.wikipedia.org/wiki/Eravacycline  :

        https://en.wikipedia.org/wiki/Eravacycline

    98. https://en.wikipedia.org/wiki/Omadacycline_plazomicin  :

        https://en.wikipedia.org/wiki/Omadacycline_plazomicin

    99. https://en.wikipedia.org/wiki/Remimazolam  :

        https://en.wikipedia.org/wiki/Remimazolam

    100. https://en.wikipedia.org/wiki/Lumateperone  :

         https://en.wikipedia.org/wiki/Lumateperone

    101. https://en.wikipedia.org/wiki/Rifamycin  :

         https://en.wikipedia.org/wiki/Rifamycin

    102. https://en.wikipedia.org/wiki/Triclabendazole  :

         https://en.wikipedia.org/wiki/Triclabendazole

    103. https://en.wikipedia.org/wiki/Artesunate  :

         https://en.wikipedia.org/wiki/Artesunate

    104. https://en.wikipedia.org/wiki/Moxidectin  :

         https://en.wikipedia.org/wiki/Moxidectin

    105. https://en.wikipedia.org/wiki/Tafenoquine  :

         https://en.wikipedia.org/wiki/Tafenoquine

    106. https://en.wikipedia.org/wiki/Off-label_use  :

         https://en.wikipedia.org/wiki/Off-label_use

    107. Donepezil

    108. https://en.wikipedia.org/wiki/Acetylcholinesterase_inhibitor  :

         https://en.wikipedia.org/wiki/Acetylcholinesterase_inhibitor

    109. https://en.wikipedia.org/wiki/Derek_Lowe_(chemist)  :

         https://en.wikipedia.org/wiki/Derek_Lowe_(chemist)

    110. Survivorship bias