AI

• “ELIZA Reanimated: The world’s first chatbot restored on the world’s first time sharing system”, Lane et al 2025

Matters Of Scale:

Genetics

Everything Is Heritable:

• “Within-family heritability estimates for behavioural and disease phenotypes from 500,000 sibling pairs of diverse ancestries”, Yengo et al 2025

Recent Evolution:

Engineering:

• “Megabase-scale human genome rearrangement with programmable bridge recombinases”, Perry et al 2025

• “Induction of experimental cell division to generate cells with reduced chromosome ploidy”, Gutierrez et al 2025 (Pluripotent stem cells are useful, but hard to use, for the same reason blank books and new hard drives are. If that sounds easy to you, remember, ‘all’ you have to do to write like Shakespeare is predict the next letter he would write—repeatedly. Surely you can predict one letter…?)

Statistics/Meta-Science

• “Adventures in State Space”, 2swap 2025 (visualizing a hard sliding-block puzzle’s game tree as a graph to understand why it’s hard, its symmetries, and the qualitative nature of its strategies; good intuition building for the idea of ‘state spaces’ in planning & reinforcement learning)

Politics/Religion

Psychology/Biology

• “Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment”, Wharton et al 2025

• “ChatGPT Is Blowing Up Marriages as Spouses Use AI to Attack Their Partners”; “The Rise of Parasitic AI”, Adele Lopez 2025-09-11

Technology

• “The Making of Printing Types”, Nicholas Rougeux2025

• “‘New York and Erie Railroad Organizational Diagram’: A recreation of one of the first charts of its kind from the 19^th century”, Nicholas Rougeux2025

• “Random Mosaic: Detecting unauthorized physical access with beans, lentils and colored rice”

• “Making my own wedding rings”, Geoff Greer2024 (HN; lost-wax gold/silver rings)

Economics

Philosophy

Fiction