‘animal study methodology’ directory
- See Also
- Gwern
- Links
- “Estimating the Replicability of Brazilian Biomedical Science ”, Amaral et al 2025
- “Huge Reproducibility Project Fails to Validate Dozens of Biomedical Studies: Unique Reproducibility Effort in Brazil Focuses on Common Methods rather than a Single Field―and Prompts Call for Reform ”, Andrade 2025
- “The Impact of Short-Lived Controls on the Interpretation of Lifespan Experiments and Progress in Geroscience—Through the Lens of the ‘900-Day Rule’ ”, Pabis et al 2024
- “Dietary Restriction Impacts Health and Lifespan of Genetically Diverse Mice ”, Francesco et al 2024
- “Laboratory Horror Stories: Poison in the Agars ”, Davidson et al 2024
- “Fraudulent Studies Are Undermining the Reliability of Systematic Reviews—A Study of the Prevalence of Problematic Images in Preclinical Studies of Depression ”, Berrío & Kalliokoski 2024
- “The Fight Against Cancer Turns to a Special Class of Carcinogens ”
- “Experimenters’ Sex Modulates Mouse Behaviors and Neural Responses to Ketamine via Corticotropin Releasing Factor ”, Georgiou et al 2022
- “C60 in Olive Oil Causes Light-Dependent Toxicity and Does Not Extend Lifespan in Mice ”, Grohn et al 2020
- “Millions of Animals May Be Missing from Scientific Studies ”, Chawla 2020
- “Publication Rate in Preclinical Research: a Plea for Preregistration ”, Naald et al 2020
- “Testing the Low Dose Mixtures Hypothesis from the Halifax Project ”, Goodson et al 2020
- “Reproducibility of Animal Research in Light of Biological Variation ”, Voelkl et al 2020
- “Establishing or Exaggerating Causality for the Gut Microbiome: Lessons from Human Microbiota-Associated Rodents ”, Walter et al 2020
- “Individual Differences in Behavior Explain Variation in Survival: a Meta-Analysis ”, Moiron et al 2019
- “Depression Researchers Rethink Popular Mouse Swim Tests: Animal-Rights Group’s Campaign to End Forced-Swim Tests Comes amid Debate over Whether Method Is Overused ”, Reardon 2019b
- “Genetically Heterogeneous Mice Exhibit a Female Survival Advantage That Is Age-Specific and Site-Specific: Results from a Large Multi-Site Study ”, Cheng et al 2019
- “What Exactly Is ‘N’ in Cell Culture and Animal Experiments? ”, Lazic et al 2017
- “A Long Journey to Reproducible Results: Replicating Our Work Took Four Years and 100,000 Worms but Brought Surprising Discoveries ”, Lithgow et al 2017
- “Impact of Genetic Background and Experimental Reproducibility on Identifying Chemical Compounds With Robust Longevity Effects ”, Lucanic et al 2017
- “Reproducibility and Replicability of Rodent Phenotyping in Preclinical Studies ”, Kafkafi et al 2016
- “Thermoneutrality, Mice, and Cancer: A Heated Opinion ”, Hylander & Repasky 2016
- “Low-Dose Paroxetine Exposure Causes Lifetime Declines in Male Mouse Body Weight, Reproduction and Competitive Ability As Measured by the Novel Organismal Performance Assay ”, Ruff et al 2015
- “When Mice Mislead: Tackling a Long-Standing Disconnect between Animal and Human Studies, Some Charge That Animal Researchers Need Stricter Safeguards and Better Statistics to Ensure Their Science Is Solid ”, Couzin-Frankel 2013
- “Baseline Tumor Growth and Immune Control in Laboratory Mice Are Importantly Influenced by Subthermoneutral Housing Temperature ”, Kokolus et al 2013
- “Monument to the Laboratory Mouse ”, Gelbukh 2013
- “Evaluation of Excess Statistical-Significance Bias in Animal Studies of Neurological Diseases ”, Tsilidis et al 2013
- “Reproducibility Problems in Animal Studies in Science & Medicine ”, Gwern 2013
- “Look Back in Anger—What Clinical Studies Tell Us about Preclinical Work ”, Hartung 2013
- “Genomic Responses in Mouse Models Poorly Mimic Human Inflammatory Diseases ”, Seok 2013
- “Publication Bias in Laboratory Animal Research: A Survey on Magnitude, Drivers, Consequences and Potential Solutions ”, Riet et al 2012
- “Believe It or Not: How Much Can We Rely on Published Data on Potential Drug Targets? ”, Prinz 2011
- “Improving the Translational Hit of Experimental Treatments in Multiple Sclerosis ”, Vesterinen et al 2010
- “Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy ”, Sena et al 2010
- “Why Are So Many Epidemiology Associations Inflated or Wrong? Does Poorly Conducted Animal Research Suggest Implausible Hypotheses? ”, Bracken 2009
- “Systematic Reviews of Animal Experiments Demonstrate Poor Contributions Toward Human Healthcare ”, Knight 2008
- “Translating Animal Research into Clinical Benefit ”, Hackam 2007
- “A Systematic Review of Systematic Reviews and Meta-Analyses of Animal Experiments With Guidelines for Reporting ”, Peters et al 2006
- “The Future of Teratology Research Is In Vitro ”, Bailey et al 2005
- “Where Is the Evidence That Animal Research Benefits Humans? ”, Pound et al 2004
- “The Reserve-Capacity Hypothesis: Evolutionary Origins and Modern Implications of the Trade-Off between Tumor-Suppression and Tissue-Repair ”, Weinstein & Ciszek 2002
- “Evidence-Based Data From Animal and Human Experimental Studies on Pain Relief With Antidepressants: A Structured Review ”, Fishbain et al 2000
- “Concordance of the Toxicity of Pharmaceuticals in Humans and in Animals ”, Olson et al 2000
- “Induction of Drug-Metabolizing Enzymes in Liver Microsomes of Mice and Rats by Softwood Bedding ”, Vesell 1967
- “The Importance of Being Cross-Bred ”, Michie & McLaren 1955
- “The Effects of Olfactory Cues on the Maze Learning of White Rats ”, Mand 1940
- “Experiments Using Mice Are Often Heavily Publicised—But Very, Very Few of Them Translate into Humans. Anthony King Reports on Why Animal Models Are of Questionable Value. ”
- “Two Years Later: Journals Are Not Yet Enforcing the ARRIVE Guidelines on Reporting Standards for Pre-Clinical Animal Studies ”, Baker et al 2026
- “Can Animal Models of Disease Reliably Inform Human Studies? ”, Worp et al 2026
- “The Mouse As a Microscope ”
- “A Primer on Why Computational Predictive Toxicology Is Hard ”
- “The Mouse Trap: The Dangers of Using One Lab Animal to Study Every Disease ”
- Sort By Magic
- Wikipedia (1)
- Miscellaneous
- Bibliography
See Also
Gwern
“Apollonian 1: The Counted and the Crowned ”, Gwern et al 2025
Links
“Estimating the Replicability of Brazilian Biomedical Science ”, Amaral et al 2025
Estimating the replicability of Brazilian biomedical science
“Huge Reproducibility Project Fails to Validate Dozens of Biomedical Studies: Unique Reproducibility Effort in Brazil Focuses on Common Methods rather than a Single Field―and Prompts Call for Reform ”, Andrade 2025
“The Impact of Short-Lived Controls on the Interpretation of Lifespan Experiments and Progress in Geroscience—Through the Lens of the ‘900-Day Rule’ ”, Pabis et al 2024
“Dietary Restriction Impacts Health and Lifespan of Genetically Diverse Mice ”, Francesco et al 2024
Dietary restriction impacts health and lifespan of genetically diverse mice
“Laboratory Horror Stories: Poison in the Agars ”, Davidson et al 2024
“Fraudulent Studies Are Undermining the Reliability of Systematic Reviews—A Study of the Prevalence of Problematic Images in Preclinical Studies of Depression ”, Berrío & Kalliokoski 2024
“The Fight Against Cancer Turns to a Special Class of Carcinogens ”
The Fight Against Cancer Turns to a Special Class of Carcinogens
“Experimenters’ Sex Modulates Mouse Behaviors and Neural Responses to Ketamine via Corticotropin Releasing Factor ”, Georgiou et al 2022
“C60 in Olive Oil Causes Light-Dependent Toxicity and Does Not Extend Lifespan in Mice ”, Grohn et al 2020
C60 in olive oil causes light-dependent toxicity and does not extend lifespan in mice
“Millions of Animals May Be Missing from Scientific Studies ”, Chawla 2020
“Publication Rate in Preclinical Research: a Plea for Preregistration ”, Naald et al 2020
Publication rate in preclinical research: a plea for preregistration
“Testing the Low Dose Mixtures Hypothesis from the Halifax Project ”, Goodson et al 2020
Testing the low dose mixtures hypothesis from the Halifax project
“Reproducibility of Animal Research in Light of Biological Variation ”, Voelkl et al 2020
Reproducibility of animal research in light of biological variation
“Establishing or Exaggerating Causality for the Gut Microbiome: Lessons from Human Microbiota-Associated Rodents ”, Walter et al 2020
“Individual Differences in Behavior Explain Variation in Survival: a Meta-Analysis ”, Moiron et al 2019
Individual differences in behavior explain variation in survival: a meta-analysis
“Depression Researchers Rethink Popular Mouse Swim Tests: Animal-Rights Group’s Campaign to End Forced-Swim Tests Comes amid Debate over Whether Method Is Overused ”, Reardon 2019b
“Genetically Heterogeneous Mice Exhibit a Female Survival Advantage That Is Age-Specific and Site-Specific: Results from a Large Multi-Site Study ”, Cheng et al 2019
“What Exactly Is ‘N’ in Cell Culture and Animal Experiments? ”, Lazic et al 2017
“A Long Journey to Reproducible Results: Replicating Our Work Took Four Years and 100,000 Worms but Brought Surprising Discoveries ”, Lithgow et al 2017
“Impact of Genetic Background and Experimental Reproducibility on Identifying Chemical Compounds With Robust Longevity Effects ”, Lucanic et al 2017
“Reproducibility and Replicability of Rodent Phenotyping in Preclinical Studies ”, Kafkafi et al 2016
Reproducibility and replicability of rodent phenotyping in preclinical studies
“Thermoneutrality, Mice, and Cancer: A Heated Opinion ”, Hylander & Repasky 2016
“Low-Dose Paroxetine Exposure Causes Lifetime Declines in Male Mouse Body Weight, Reproduction and Competitive Ability As Measured by the Novel Organismal Performance Assay ”, Ruff et al 2015
“When Mice Mislead: Tackling a Long-Standing Disconnect between Animal and Human Studies, Some Charge That Animal Researchers Need Stricter Safeguards and Better Statistics to Ensure Their Science Is Solid ”, Couzin-Frankel 2013
“Baseline Tumor Growth and Immune Control in Laboratory Mice Are Importantly Influenced by Subthermoneutral Housing Temperature ”, Kokolus et al 2013
“Monument to the Laboratory Mouse ”, Gelbukh 2013
“Evaluation of Excess Statistical-Significance Bias in Animal Studies of Neurological Diseases ”, Tsilidis et al 2013
Evaluation of Excess Statistical-Significance Bias in Animal Studies of Neurological Diseases
“Reproducibility Problems in Animal Studies in Science & Medicine ”, Gwern 2013
Reproducibility Problems in Animal Studies in Science & Medicine
“Look Back in Anger—What Clinical Studies Tell Us about Preclinical Work ”, Hartung 2013
Look back in anger—what clinical studies tell us about preclinical work
“Genomic Responses in Mouse Models Poorly Mimic Human Inflammatory Diseases ”, Seok 2013
Genomic responses in mouse models poorly mimic human inflammatory diseases
“Publication Bias in Laboratory Animal Research: A Survey on Magnitude, Drivers, Consequences and Potential Solutions ”, Riet et al 2012
“Believe It or Not: How Much Can We Rely on Published Data on Potential Drug Targets? ”, Prinz 2011
Believe it or not: how much can we rely on published data on potential drug targets?
“Improving the Translational Hit of Experimental Treatments in Multiple Sclerosis ”, Vesterinen et al 2010
Improving the translational hit of experimental treatments in multiple sclerosis
“Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy ”, Sena et al 2010
Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy
“Why Are So Many Epidemiology Associations Inflated or Wrong? Does Poorly Conducted Animal Research Suggest Implausible Hypotheses? ”, Bracken 2009
“Systematic Reviews of Animal Experiments Demonstrate Poor Contributions Toward Human Healthcare ”, Knight 2008
Systematic Reviews of Animal Experiments Demonstrate Poor Contributions Toward Human Healthcare
“Translating Animal Research into Clinical Benefit ”, Hackam 2007
“A Systematic Review of Systematic Reviews and Meta-Analyses of Animal Experiments With Guidelines for Reporting ”, Peters et al 2006
“The Future of Teratology Research Is In Vitro ”, Bailey et al 2005
“Where Is the Evidence That Animal Research Benefits Humans? ”, Pound et al 2004
“The Reserve-Capacity Hypothesis: Evolutionary Origins and Modern Implications of the Trade-Off between Tumor-Suppression and Tissue-Repair ”, Weinstein & Ciszek 2002
“Evidence-Based Data From Animal and Human Experimental Studies on Pain Relief With Antidepressants: A Structured Review ”, Fishbain et al 2000
“Concordance of the Toxicity of Pharmaceuticals in Humans and in Animals ”, Olson et al 2000
Concordance of the Toxicity of Pharmaceuticals in Humans and in Animals :
“Induction of Drug-Metabolizing Enzymes in Liver Microsomes of Mice and Rats by Softwood Bedding ”, Vesell 1967
Induction of Drug-Metabolizing Enzymes in Liver Microsomes of Mice and Rats by Softwood Bedding
“The Importance of Being Cross-Bred ”, Michie & McLaren 1955
The Importance of Being Cross-Bred :
View PDF:
“The Effects of Olfactory Cues on the Maze Learning of White Rats ”, Mand 1940
The effects of olfactory cues on the maze learning of white rats
“Experiments Using Mice Are Often Heavily Publicised—But Very, Very Few of Them Translate into Humans. Anthony King Reports on Why Animal Models Are of Questionable Value. ”
“Two Years Later: Journals Are Not Yet Enforcing the ARRIVE Guidelines on Reporting Standards for Pre-Clinical Animal Studies ”, Baker et al 2026
“Can Animal Models of Disease Reliably Inform Human Studies? ”, Worp et al 2026
“The Mouse As a Microscope ”
“A Primer on Why Computational Predictive Toxicology Is Hard ”
“The Mouse Trap: The Dangers of Using One Lab Animal to Study Every Disease ”
The Mouse Trap: The dangers of using one lab animal to study every disease
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causality-gut
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Wikipedia (1)
Miscellaneous
/doc/statistics/bias/animal/2003-lee.pdf:View PDF:
http://eprints.nottingham.ac.uk/439/1/Willmot_NO_synthase_JFRBM.pdf:http://psych.colorado.edu/~carey/pdfFiles/MouseLab_Crabbe.pdf:https://academic.oup.com/cardiovascres/article/91/4/649/346880https://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.138.944&rep=rep1&type=pdfhttps://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.513.1459&rep=rep1&type=pdfhttps://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.654.7344&rep=rep1&type=pdfhttps://danbaum.files.wordpress.com/2018/03/jake-leg-new-yorker.pdf:https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1553-2712.2003.tb00056.xhttps://pure.uva.nl/ws/files/3216102/15320_Thesis.pdf#page=103:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1436259/pdf/jrsocmed00293-0087.pdf:https://www.sciencedirect.com/science/article/pii/S2405471219302005https://www.tandfonline.com/doi/pdf/10.4161/15384101.2014.950151