Junkfood Science: Calorie Restrictive Eating for Longer Life? The Story We Didn’t Hear in the News
Caloric Restriction Reduces Age-Related and All-Cause Mortality in Rhesus Monkeys
Why Correlation Usually ≠ Causation
The Replication Crisis: Flaws in Mainstream Science § Animal Models
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Metformin Inhibits Mitochondrial Adaptations to Aerobic Exercise Training in Older Adults
February 2021 News § Semaglutide
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CURATED DATABASE OF GEROPROTECTORS
Use of Glucosamine and Chondroitin in Relation to Mortality
Dietary Magnesium Intake Is Inversely Associated With Mortality in Adults at High Cardiovascular Disease Risk
Low-Dose Lithium Uptake Promotes Longevity in Humans and Metazoans
https://www.nejm.org/doi/full/10.1056/NEJMoa1511939
https://www.nejm.org/doi/suppl/10.1056/NEJMoa1511939/suppl_file/nejmoa1511939_appendix.pdf#page=2
Primary Prevention of Cardiovascular Disease With a Mediterranean Diet Supplemented With Extra-Virgin Olive Oil or Nuts
2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity
Effects of Castration on the Life Expectancy of Contemporary Men
Effects of Castration on the Life Expectancy of Contemporary Men
Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice
Dogs Test Drug Aimed at Humans’ Biggest Killer: Age
https://link.springer.com/article/10.1007/s11357-017-9972-z
Are the Benefits of Moderate Drinking a Myth?
Mortality Hazard Rates and Life Expectancy
Computational Analysis of Lifespan Experiment Reproducibility
A Weakly Informative Default Prior Distribution for Logistic and Other Regression Models
Performance of informative priors skeptical of large treatment effects in clinical trials: A simulation study
Vitamin D and Calcium: A Systematic Review of Health Outcomes (Update)
Vitamin D and Multiple Health Outcomes: Umbrella Review of Systematic Reviews and Meta-Analyses of Observational Studies and Randomized Trials
Genetic variants and associations of 25-hydroxyvitamin D concentrations with major clinical outcomes
https://academic.oup.com/clinchem/article/59/5/793/5622179
https://academic.oup.com/clinchem
Genetically Low Vitamin D Concentrations and Increased Mortality: Mendelian Randomization Analysis in Three Large Cohorts
https://scholar.google.com/scholar?q=%22vitamin+d%22+all-cause+mortality+meta-analysis&btnG=&as_sdt=0%2C21&as_ylo=2012
Vitamin D Supplementation and Total Mortality: A Meta-Analysis of Randomized Controlled Trials
Extraskeletal Effects of Vitamin D in Older Adults: Cardiovascular Disease, Mortality, Mood, and Cognition
Vitamin D and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis
Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women’s Health Initiative limited access dataset and meta-analysis
Vitamin D with calcium reduces mortality: patient level pooled analysis of 70,528 patients from eight major vitamin D trials
Meta-analysis of long-term vitamin D supplementation on overall mortality
2013-lazzeroni.pdf
Vitamin D Supplementation for Prevention of Cancer in Adults (Review)
Vitamin D Supplementation for Prevention of Mortality in Adults
2014-bolland.pdf
Vitamin D and Risk of Cause Specific Death: Systematic Review and Meta-Analysis of Observational Cohort and Randomized Intervention Studies
Vitamin D Status and Ill Health: a Systematic Review
2014-autier-appendix.pdf
Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men
A meta-analysis of high dose, intermittent vitamin D supplementation among older adults
1983-inkovaara.pdf
1985-corless.pdf
1996-lips.pdf
https://www.columbia.edu/itc/hs/pubhealth/p8403/readings/lips.pdf
1998-komulainen.pdf
Prevention of Femoral and Lumbar Bone Loss with Hormone Replacement Therapy and Vitamin D3 in Early Postmenopausal Women: A Population-Based 5–Year Randomized Trial
https://onlinelibrary.wiley.com/doi/10.1359/jbmr.2002.17.4.709/full
https://onlinelibrary.wiley.com/doi/10.1359/jbmr.2003.18.2.343/full
https://www.sciencedirect.com/science/article/pii/S0002916523057817
A Randomized, Controlled Trial of Quadriceps Resistance Exercise and Vitamin D in Frail Older People: The Frailty Interventions Trial in Elderly Subjects (FITNESS)
Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomized double blind controlled trial
2004-avenell.pdf
https://ageing.oxfordjournals.org/content/33/1/45.full.pdf+html
A Randomized Controlled Trial of Vitamin D3 Supplementation in African American Women
Should Older People in Residential Care Receive Vitamin D to Prevent Falls? Results of a Randomized Trial
Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomized Evaluation of Calcium Or vitamin D, RECORD): a randomized placebo-controlled trial
2007-broe.pdf
https://academic.oup.com/ageing/article/36/5/507/40586
Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial
2007-lyons.pdf
https://academic.oup.com/rheumatology/article/46/12/1852/1789226
https://academic.oup.com/ageing/article/37/1/25/24810
https://link.springer.com/article/10.1007/s00198-007-0465-2
Effects of Ergocalciferol Added to Calcium on the Risk of Falls in Elderly High-Risk Women
Effects of Calcium and Vitamin D Supplementation on Hip Bone Mineral Density and Calcium-Related Analytes in Elderly Ambulatory Australian Women: A Five-Year Randomized Controlled Trial
Once-Weekly Dose of 8400 IU Vitamin D3 Compared With Placebo: Effects on Neuromuscular Function and Tolerability in Older Adults With Vitamin D Insufficiency
Annual High-Dose Oral Vitamin D and Falls and Fractures in Older Women: A Randomized Controlled Trial
https://onlinelibrary.wiley.com/doi/10.1002/jbmr.524/full
Vitamin D3 and Calcium to Prevent Hip Fractures in Elderly Women
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2539939/pdf/bmj00437-0035.pdf
https://www.columbia.edu/itc/hs/pubhealth/p8403/readings/dawson-hughes.pdf
1998-baeksgaard.pdf
1999-krieg.pdf
2002-chapuy.pdf
https://onlinelibrary.wiley.com/doi/10.1359/JBMR.040511/full
2005-brazier.pdf
Randomized controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care
2006-jackson.pdf
https://www.nejm.org/doi/full/10.1056/NEJMoa055222
https://circ.ahajournals.org/content/115/7/846.full
https://onlinelibrary.wiley.com/doi/10.1359/jbmr.070116/full
https://onlinelibrary.wiley.com/doi/10.1002/jbmr.48/full
CRAN: Package Bayesmeta
https://www.amazon.com/gp/product/B0050MYHBQ/
https://www.cochranelibrary.com/doi/10.1002/14651858.CD007469.pub2/pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410276/figure/F3/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410276/table/T1/
‘I Think There’s No Doubt That Insulin Is Pro-Cancer”, Watson Says, with respect to the Link between Obesity, Diabetes and Cancer. “It’s As Good a Hypothesis As We Have Now.’ Watson Takes Metformin for Cancer Prevention; among Its Many Effects, Metformin Works to Lower Insulin Levels.
The Man Who Wants to Beat Back Aging: Nir Barzilai Hopes to Persuade FDA to Bless the Proposed Anti-Aging Trial, Which Is Unconventional in Its Goals and Design.
Dr. Nir Barzilai on the TAME Study
Anti-Ageing Pill Pushed As Bona Fide Drug: Regulators Asked to Consider Ageing a Treatable Condition
Metformin in Longevity Study (MILES)
Metformin As a Tool to Target Aging
https://www.cochranelibrary.com/doi/10.1002/14651858.CD002966.pub3/epdf/standard
Cardiovascular Outcomes in Trials of Oral Diabetes Medications: A Systematic Review Acute Coronary Syndromes
2011-lamanna.pdf
2012-stevens.pdf
Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis
Metformin As a Geroprotector
Metformin in obesity, cancer and aging: addressing controversies
Metformin: do we finally have an anti-aging drug?
Metformin and Aging: A Review
2014-bannister.pdf
Metformin Dosage Guide + Max Dose, Adjustments
Metformin (Oral Route) Proper Use
https://www.goodrx.com/metformin
Not Found
Metformin Side Effects: Common, Severe, Long Term
2002-fda-metforminhydrochloridetablets-prescribinginformation.pdf
Metformin and Fatal Lactic Acidosis
The Value of Health and Longevity
A Multi-Tissue Full Lifespan Epigenetic Clock for Mice
Epigenetic clocks: A review
TRIIM: Reversal of epigenetic aging and immunosenescent trends in humans
Reversal of Epigenetic Age with Diet and Lifestyle in a Pilot Randomized Clinical Trial
The economic value of targeting aging
https://www.longevityhistory.com/book/indexb.html
Which Risks of Dying Are Worth Taking?
Who By Very Slow Decay
GBD Compare
What Does a 13% Increased Risk of Death Mean?
The quest to slow ageing through drug discovery