Heritable Polygenic Editing: the next Frontier in Genomic Medicine?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356746/bin/mp2014188x3.xlsx
George Church on Germline Human Genetic Modification
Heritability of performance deficit accumulation during acute sleep deprivation in twins
https://www.reddit.com/r/science/comments/3kj669/science_ama_series_im_yinghui_fu_i_study_the/cuy7fjh/
What It’s Like to Need Hardly Any Sleep: ‘I Get 3 or Four Hours Sleep a Night, and I Never Get Tired.’
The Sleepless Elite: Why Some People Can Run on Little Sleep and Get So Much Done
The People Who Need Very Little Sleep: Is It True That Some People Need Only a Few Hours of Sleep? Helen Thomson Talks to a Woman Whose Genes Might Hint at How We All Could Survive on Less Shuteye
8 Is Too Much For ‘Short Sleepers’
A Sleep Diary and Questionnaire Study of Naturally Short Sleepers
https://www.reddit.com/r/science/comments/3kj669/science_ama_series_im_yinghui_fu_i_study_the/cuy8cts/
A Gene That Makes You Need Less Sleep?
The transcriptional repressor DEC2 regulates sleep length in mammals
A novel BHLHE41 variant is associated with short sleep and resistance to sleep deprivation in humans
Rs4963956 RefSNP Report
Rs1480037 RefSNP Report
Rs4963955 RefSNP Report
The Death of the National Children's Study: What Went Wrong?
https://www.cdc.gov/art/pdf/2013-report/art_2013_national_summary_report.pdf
‘leaky pipelines’ directory
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
RNA-programmed genome editing in human cells
There‘s CRISPR in Your Yogurt: We’ve All Been Eating Food Enhanced by the Genome-Editing Tool for Years
CRISPR Gene Therapy: Scientists Call for More Public Debate around Breakthrough Technique
A Call to Fight Malaria One Mosquito at a Time by Altering DNA
Efficient genome editing in zebrafish using a CRISPR-Cas system
https://www.nature.com/articles/522020a
Boom in Human Gene Editing As 20 CRISPR Trials Gear Up: A Pioneering CRISPR Trial in China Will Be the First to Try Editing the Genomes of Cells inside the Body, in an Effort to Eliminate Cancer-Causing HPV Virus
Gene-Edited ‘Micropigs’ to Be Sold As Pets at Chinese Institute: The Pigs Are Endearing but Scientists Warn That They May Be a Distraction from More Serious Research
Genome Edited Sheep and Cattle
Super-Muscly Pigs Created by Small Genetic Tweak: Researchers Hope the Genetically Engineered Animals Will Speed past Regulators
2017-midic.pdf
Generation of Gene-Target Dogs Using CRISPR/Cas9 System
Efficient Gene Knockout in Goats Using CRISPR/Cas9 System
Generation of Gene-Modified Goats Targeting MSTN and FGF5 via Zygote Injection of CRISPR/Cas9 System
CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
Embryo Editing Sparks Epic Debate: In Wake of Paper Describing Genetic Modification of Human Embryos, Scientists Disagree about Ethics
In Vivo CRISPR/Cas9 Gene Editing Corrects Retinal Dystrophy in the S334ter-3 Rat Model of Autosomal Dominant Retinitis Pigmentosa
Gene and Mutation Independent Therapy via CRISPR-Cas9 Mediated Cellular Reprogramming in Rod Photoreceptors
Precision Medicine: Genetic Repair of Retinitis Pigmentosa in Patient-Derived Stem Cells
Biotech Company Plans To Use CRISPR On People In Next Two Years
Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA
Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype
Therapeutic Genome Editing by Combined Viral and Non-Viral Delivery of CRISPR System Components in Vivo
Correction of a Genetic Disease in Mouse via Use of CRISPR-Cas9
Penn Scientists Use CRISPR for First Time to Correct Clotting in Newborn and Adult Mice: Findings Presented at ASH Meeting Offer Clues about Use of Gene Editing for Disease-Causing Mutations
In Vivo Excision of HIV-1 Provirus by SaCas9 and Multiplex Single-Guide RNAs in Animal Models
Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients
Harnessing the CRISPR/Cas9 System to Disrupt Latent HIV-1 Provirus
Elimination of HIV-1 Genomes from Human T-Lymphoid Cells by CRISPR/Cas9 Gene Editing
Genome-Wide Inactivation of Porcine Endogenous Retroviruses (PERVs)
Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9
Enabling large-scale genome editing by reducing DNA nicking
Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases
One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering
Simultaneous Generation and Germline Transmission of Multiple Gene Mutations in Rat Using CRISPR-Cas Systems
Mammoth Genomes Provide Recipe for Creating Arctic Elephants: Catalogue of Genetic Differences between Woolly Mammoths and Elephants Reveals How Ice-Age Giants Braved the Cold
Multiplex Genome Engineering in Human Cells Using All-In-One CRISPR/Cas9 Vector System
RNA-guided human genome engineering via Cas9
RNA-guided gene drives can efficiently and reversibly bias inheritance in wild yeast
Genome editing. The mutagenic chain reaction: a method for converting heterozygous to homozygous mutations
Highly Efficient Cas9-Mediated Gene Drive for Population Modification of the Malaria Vector Mosquito Anopheles Stephensi
A CRISPR-Cas9 Gene Drive System Targeting Female Reproduction in the Malaria Mosquito Vector Anopheles Gambiae
Woolly Mammoth DNA Successfully Spliced Into Elephant Cells But Don't Expect Mammoth Clones Anytime Soon
Gene-Edited Pigs Are Protected from Porcine Reproductive and Respiratory Syndrome Virus
Efficient Nonmeiotic Allele Introgression in Livestock Using Custom Endonucleases
Single Cas9 Nickase Induced Generation of NRAMP1 Knockin Cattle With Reduced Off-Target Effects
CRISPR/Cas9-Mediated Genome Engineering of the Ferret
2016-liu-2.pdf
Gene-Edited CRISPR Mushroom Escapes US Regulation: A Fungus Engineered With the CRISPR-Cas9 Technique Can Be Cultivated and Sold without Further Oversight
Welcome to the CRISPR Zoo
Editing Out Pesticides
RNA-guided human genome engineering via Cas9
Extensive Mammalian Germline Genome Engineering
Eyeing organs for human transplants, companies unveil the most extensively gene-edited pigs yet
Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9
Proxy-Phenotype Method Identifies Common Genetic Variants Associated with Cognitive Performance
Schizophrenia Risk from Complex Variation of Complement Component 4
Genetic and Epigenetic Fine Mapping of Causal Autoimmune Disease Variants
Polygenic Influence on Educational Attainment: New Evidence from the National Longitudinal Study of Adolescent to Adult Health
Educational attainment-related loci identified by GWAS are associated with select personality traits and mathematics and language abilities
A Review of Intelligence GWAS Hits: Their Relationship to Country IQ and the Issue of Spatial Autocorrelation
Admixture Mapping Comes of Age
Generalization and Dilution of Association Results from European GWAS in Populations of Non-European Ancestry: The PAGE Study
Consistent Association of Type 2 Diabetes Risk Variants Found in Europeans in Diverse Racial and Ethnic Groups
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations
A Novel, Functional and Replicable Risk Gene Region for Alcohol Dependence Identified by Genome-Wide Association Study
Race / Ethnic Variation in the Association of Lipid-Related Genetic Variants With Blood Lipids in the Adult U.S. Population
Genome-wide association meta-analysis identifies new endometriosis risk loci
Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study
Fine-Mapping and Identification of BMI Loci in African Americans
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry
Transethnic Replication of Association of CTG18.1 Repeat Expansion of TCF4 Gene With Fuchs' Corneal Dystrophy in Chinese Implies Common Causal Variant
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
Genome-Wide Meta-Analysis Identifies Multiple Novel Associations and Ethnic Heterogeneity of Psoriasis Susceptibility
Genetic studies of body mass index yield new insights for obesity biology
2015-he.pdf
Additive Genetic Variation in Schizophrenia Risk Is Shared by Populations of African and European Descent
Biological insights from 108 schizophrenia-associated genetic loci
Genome-Wide Complex Trait Analysis
Transethnic Differences in GWAS Signals: A Simulation Study
Transethnic Genetic-Correlation Estimates from Summary Statistics
Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT)
Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error
Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations
Lessons learned from bugs in models of human history
Trans-Ethnic Genome-Wide Association Studies: Advantages and Challenges of Mapping in Diverse Populations
2018-wray.pdf
Genetic Diversity Turns a New PAGE in Our Understanding of Complex Traits
Genome-wide association study identifies 112 new loci for body mass index in the Japanese population
Generalizing Genetic Risk Scores from Europeans to Hispanics/Latinos
Genetic architecture of gene expression traits across diverse populations
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations
Polygenic prediction of the phenome, across ancestry, in emerging adulthood
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971142/bin/NIHMS933200-supplement-SupplementA.pdf
https://www.nature.com/articles/s41398-018-0236-1
Comparing distributions of polygenic risk scores of type 2 diabetes and coronary heart disease within different populations
Analysis of Polygenic Score Usage and Performance across Diverse Human Populations
Transancestral GWAS of Alcohol Dependence Reveals Common Genetic Underpinnings With Psychiatric Disorders
The transferability of lipid-associated loci across African, Asian and European cohorts
Identification of 28 New Susceptibility Loci for Type 2 Diabetes in the Japanese Population
Identification of type 2 diabetes loci in 433,540 East Asian individuals
Genetic Analyses of Diverse Populations Improves Discovery for Complex Traits
https://www.nature.com/articles/s41380-019-0517-y
Quantifying genetic heterogeneity between continental populations for human height and body mass index
Population-specific and transethnic genome-wide analyses reveal distinct and shared genetic risks of coronary artery disease
Genetic Risk Scores for Cardiometabolic Traits in Sub-Saharan African Populations
Inclusion of variants discovered from diverse populations improves polygenic risk score transferability
Predictive Power of Early Childhood IQ
Optimal Regret Analysis of Thompson Sampling in Stochastic Multi-armed Bandit Problem with Multiple Plays
An Empirical Evaluation of Thompson Sampling
One Hundred Years of Statistical Developments in Animal Breeding
5 Heritable Genome Editing Human Genome Editing: Science, Ethics, and Governance
China officially bans CRISPR babies, human clones and animal-human hybrids
Estimating the Mutation Load in Human Genomes
The Deleterious Mutation Load Is Insensitive to Recent Population History
2014-simons-supplementary.pdf
Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants
Parental Influence on Human Germline de Novo Mutations in 1,548 Trios from Iceland
Genome Graphs and the Evolution of Genome Inference
A Global Reference for Human Genetic Variation
Resolving the complexity of the human genome using single-molecule sequencing
De Novo Assembly and Phasing of a Korean Human Genome
Linkage disequilibrium-dependent architecture of human complex traits shows action of negative selection
Quantification of frequency-dependent genetic architectures and action of negative selection in 25 UK Biobank traits
Refining the Accuracy of Validated Target Identification through Coding Variant Fine-Mapping in Type 2 Diabetes