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Heritable Polygenic Editing: the next Frontier in Genomic Medicine?
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356746/bin/mp2014188x3.xlsx
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George Church on Germline Human Genetic Modification
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Heritability of performance deficit accumulation during acute sleep deprivation in twins
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https://www.reddit.com/r/science/comments/3kj669/science_ama_series_im_yinghui_fu_i_study_the/cuy7fjh/
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What It’s Like to Need Hardly Any Sleep: ‘I Get 3 or Four Hours Sleep a Night, and I Never Get Tired.’
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The Sleepless Elite: Why Some People Can Run on Little Sleep and Get So Much Done
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The People Who Need Very Little Sleep: Is It True That Some People Need Only a Few Hours of Sleep? Helen Thomson Talks to a Woman Whose Genes Might Hint at How We All Could Survive on Less Shuteye
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8 Is Too Much For ‘Short Sleepers’
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A Sleep Diary and Questionnaire Study of Naturally Short Sleepers
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https://www.reddit.com/r/science/comments/3kj669/science_ama_series_im_yinghui_fu_i_study_the/cuy8cts/
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A Gene That Makes You Need Less Sleep?
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The transcriptional repressor DEC2 regulates sleep length in mammals
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A novel BHLHE41 variant is associated with short sleep and resistance to sleep deprivation in humans
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Rs4963956 RefSNP Report
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Rs1480037 RefSNP Report
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Rs4963955 RefSNP Report
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The Death of the National Children's Study: What Went Wrong?
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https://www.cdc.gov/art/pdf/2013-report/art_2013_national_summary_report.pdf
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Leaky Pipelines
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A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
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RNA-programmed genome editing in human cells
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There‘s CRISPR in Your Yogurt: We’ve All Been Eating Food Enhanced by the Genome-Editing Tool for Years
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CRISPR Gene Therapy: Scientists Call for More Public Debate around Breakthrough Technique
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A Call to Fight Malaria One Mosquito at a Time by Altering DNA
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Efficient genome editing in zebrafish using a CRISPR-Cas system
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https://www.nature.com/articles/522020a
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Boom in Human Gene Editing As 20 CRISPR Trials Gear Up: A Pioneering CRISPR Trial in China Will Be the First to Try Editing the Genomes of Cells inside the Body, in an Effort to Eliminate Cancer-Causing HPV Virus
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Gene-Edited ‘Micropigs’ to Be Sold As Pets at Chinese Institute: The Pigs Are Endearing but Scientists Warn That They May Be a Distraction from More Serious Research
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Genome Edited Sheep and Cattle
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Super-Muscly Pigs Created by Small Genetic Tweak: Researchers Hope the Genetically Engineered Animals Will Speed past Regulators
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2017-midic.pdf
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Generation of Gene-Target Dogs Using CRISPR/Cas9 System
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Efficient Gene Knockout in Goats Using CRISPR/Cas9 System
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Generation of Gene-Modified Goats Targeting MSTN and FGF5 via Zygote Injection of CRISPR/Cas9 System
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CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
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Embryo Editing Sparks Epic Debate: In Wake of Paper Describing Genetic Modification of Human Embryos, Scientists Disagree about Ethics
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In Vivo CRISPR/Cas9 Gene Editing Corrects Retinal Dystrophy in the S334ter-3 Rat Model of Autosomal Dominant Retinitis Pigmentosa
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Gene and Mutation Independent Therapy via CRISPR-Cas9 Mediated Cellular Reprogramming in Rod Photoreceptors
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Precision Medicine: Genetic Repair of Retinitis Pigmentosa in Patient-Derived Stem Cells
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Biotech Company Plans To Use CRISPR On People In Next Two Years
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Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA
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Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype
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Therapeutic Genome Editing by Combined Viral and Non-Viral Delivery of CRISPR System Components in Vivo
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Correction of a Genetic Disease in Mouse via Use of CRISPR-Cas9
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Penn Scientists Use CRISPR for First Time to Correct Clotting in Newborn and Adult Mice: Findings Presented at ASH Meeting Offer Clues about Use of Gene Editing for Disease-Causing Mutations
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In Vivo Excision of HIV-1 Provirus by SaCas9 and Multiplex Single-Guide RNAs in Animal Models
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Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients
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Harnessing the CRISPR/Cas9 System to Disrupt Latent HIV-1 Provirus
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Elimination of HIV-1 Genomes from Human T-Lymphoid Cells by CRISPR/Cas9 Gene Editing
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Genome-Wide Inactivation of Porcine Endogenous Retroviruses (PERVs)
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Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9
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Enabling large-scale genome editing by reducing DNA nicking
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Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases
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One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering
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Simultaneous Generation and Germline Transmission of Multiple Gene Mutations in Rat Using CRISPR-Cas Systems
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Mammoth Genomes Provide Recipe for Creating Arctic Elephants: Catalogue of Genetic Differences between Woolly Mammoths and Elephants Reveals How Ice-Age Giants Braved the Cold
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Multiplex Genome Engineering in Human Cells Using All-In-One CRISPR/Cas9 Vector System
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RNA-guided human genome engineering via Cas9
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RNA-guided gene drives can efficiently and reversibly bias inheritance in wild yeast
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Genome editing. The mutagenic chain reaction: a method for converting heterozygous to homozygous mutations
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Highly Efficient Cas9-Mediated Gene Drive for Population Modification of the Malaria Vector Mosquito Anopheles Stephensi
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A CRISPR-Cas9 Gene Drive System Targeting Female Reproduction in the Malaria Mosquito Vector Anopheles Gambiae
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Woolly Mammoth DNA Successfully Spliced Into Elephant Cells But Don't Expect Mammoth Clones Anytime Soon
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Gene-Edited Pigs Are Protected from Porcine Reproductive and Respiratory Syndrome Virus
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Efficient Nonmeiotic Allele Introgression in Livestock Using Custom Endonucleases
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Single Cas9 Nickase Induced Generation of NRAMP1 Knockin Cattle With Reduced Off-Target Effects
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CRISPR/Cas9-Mediated Genome Engineering of the Ferret
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2016-liu-2.pdf
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Gene-Edited CRISPR Mushroom Escapes US Regulation: A Fungus Engineered With the CRISPR-Cas9 Technique Can Be Cultivated and Sold without Further Oversight
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Welcome to the CRISPR Zoo
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Editing Out Pesticides
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RNA-guided human genome engineering via Cas9
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Extensive Mammalian Germline Genome Engineering
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Eyeing organs for human transplants, companies unveil the most extensively gene-edited pigs yet
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Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9
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Proxy-Phenotype Method Identifies Common Genetic Variants Associated with Cognitive Performance
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Schizophrenia Risk from Complex Variation of Complement Component 4
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Genetic and Epigenetic Fine Mapping of Causal Autoimmune Disease Variants
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Polygenic Influence on Educational Attainment: New Evidence from the National Longitudinal Study of Adolescent to Adult Health
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Educational attainment-related loci identified by GWAS are associated with select personality traits and mathematics and language abilities
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A Review of Intelligence GWAS Hits: Their Relationship to Country IQ and the Issue of Spatial Autocorrelation
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Admixture Mapping Comes of Age
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Generalization and Dilution of Association Results from European GWAS in Populations of Non-European Ancestry: The PAGE Study
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Consistent Association of Type 2 Diabetes Risk Variants Found in Europeans in Diverse Racial and Ethnic Groups
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Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations
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A Novel, Functional and Replicable Risk Gene Region for Alcohol Dependence Identified by Genome-Wide Association Study
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Race / Ethnic Variation in the Association of Lipid-Related Genetic Variants With Blood Lipids in the Adult U.S. Population
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Genome-wide association meta-analysis identifies new endometriosis risk loci
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Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study
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Fine-Mapping and Identification of BMI Loci in African Americans
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A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry
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Transethnic Replication of Association of CTG18.1 Repeat Expansion of TCF4 Gene With Fuchs' Corneal Dystrophy in Chinese Implies Common Causal Variant
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Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
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Genome-Wide Meta-Analysis Identifies Multiple Novel Associations and Ethnic Heterogeneity of Psoriasis Susceptibility
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Genetic studies of body mass index yield new insights for obesity biology
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2015-he.pdf
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Additive Genetic Variation in Schizophrenia Risk Is Shared by Populations of African and European Descent
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Biological insights from 108 schizophrenia-associated genetic loci
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Genome-Wide Complex Trait Analysis
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Transethnic Differences in GWAS Signals: A Simulation Study
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Transethnic Genetic-Correlation Estimates from Summary Statistics
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Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT)
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Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error
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Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations
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Lessons learned from bugs in models of human history
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Trans-Ethnic Genome-Wide Association Studies: Advantages and Challenges of Mapping in Diverse Populations
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2018-wray.pdf
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Genetic Diversity Turns a New PAGE in Our Understanding of Complex Traits
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Genome-wide association study identifies 112 new loci for body mass index in the Japanese population
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Generalizing Genetic Risk Scores from Europeans to Hispanics/Latinos
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Genetic architecture of gene expression traits across diverse populations
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Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
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Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations
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Polygenic prediction of the phenome, across ancestry, in emerging adulthood
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971142/bin/NIHMS933200-supplement-SupplementA.pdf
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https://www.nature.com/articles/s41398-018-0236-1
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Comparing distributions of polygenic risk scores of type 2 diabetes and coronary heart disease within different populations
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Analysis of Polygenic Score Usage and Performance across Diverse Human Populations
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Transancestral GWAS of Alcohol Dependence Reveals Common Genetic Underpinnings With Psychiatric Disorders
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The transferability of lipid-associated loci across African, Asian and European cohorts
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Identification of 28 New Susceptibility Loci for Type 2 Diabetes in the Japanese Population
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Identification of type 2 diabetes loci in 433,540 East Asian individuals
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Genetic Analyses of Diverse Populations Improves Discovery for Complex Traits
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https://www.nature.com/articles/s41380-019-0517-y
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Quantifying genetic heterogeneity between continental populations for human height and body mass index
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Population-specific and transethnic genome-wide analyses reveal distinct and shared genetic risks of coronary artery disease
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Genetic Risk Scores for Cardiometabolic Traits in Sub-Saharan African Populations
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Inclusion of variants discovered from diverse populations improves polygenic risk score transferability
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Predictive Power of Early Childhood IQ
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Optimal Regret Analysis of Thompson Sampling in Stochastic Multi-armed Bandit Problem with Multiple Plays
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An Empirical Evaluation of Thompson Sampling
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One Hundred Years of Statistical Developments in Animal Breeding
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5 Heritable Genome Editing Human Genome Editing: Science, Ethics, and Governance
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China officially bans CRISPR babies, human clones and animal-human hybrids
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Estimating the Mutation Load in Human Genomes
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The Deleterious Mutation Load Is Insensitive to Recent Population History
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2014-simons-supplementary.pdf
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Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants
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Parental Influence on Human Germline de Novo Mutations in 1,548 Trios from Iceland
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Genome Graphs and the Evolution of Genome Inference
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A Global Reference for Human Genetic Variation
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Resolving the complexity of the human genome using single-molecule sequencing
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De Novo Assembly and Phasing of a Korean Human Genome
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Linkage disequilibrium-dependent architecture of human complex traits shows action of negative selection
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Quantification of frequency-dependent genetic architectures and action of negative selection in 25 UK Biobank traits
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Refining the Accuracy of Validated Target Identification through Coding Variant Fine-Mapping in Type 2 Diabetes
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