Reproducibility Problems in Animal Studies in Science & Medicine
Fraudulent studies are undermining the reliability of systematic reviews—a study of the prevalence of problematic images in preclinical studies of depression
The Fight Against Cancer Turns to a Special Class of Carcinogens
Experimenters’ sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor
C60 in olive oil causes light-dependent toxicity and does not extend lifespan in mice
Millions of animals may be missing from scientific studies
Publication rate in preclinical research: a plea for preregistration
Testing the low dose mixtures hypothesis from the Halifax project
Reproducibility of animal research in light of biological variation
Individual differences in behavior explain variation in survival: a meta-analysis
Depression Researchers Rethink Popular Mouse Swim Tests: Animal-Rights Group’s Campaign to End Forced-Swim Tests Comes amid Debate over Whether Method Is Overused
Genetically heterogeneous mice exhibit a female survival advantage that is age-specific and site-specific: Results from a large multi-site study
What exactly is ‘N’ in cell culture and animal experiments?
A long journey to reproducible results: Replicating our work took four years and 100,000 worms but brought surprising discoveries
Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects
Reproducibility and replicability of rodent phenotyping in preclinical studies
Low-dose paroxetine exposure causes lifetime declines in male mouse body weight, reproduction and competitive ability as measured by the novel organismal performance assay
When Mice Mislead: Tackling a long-standing disconnect between animal and human studies, some charge that animal researchers need stricter safeguards and better statistics to ensure their science is solid
Baseline tumor growth and immune control in laboratory mice are importantly influenced by subthermoneutral housing temperature
Evaluation of Excess Statistical-Significance Bias in Animal Studies of Neurological Diseases
Look back in anger—what clinical studies tell us about preclinical work
Genomic Responses in Mouse Models Poorly Mimic Human Inflammatory Diseases
Publication Bias in Laboratory Animal Research: A Survey on Magnitude, Drivers, Consequences and Potential Solutions
Believe It or Not: How Much Can We Rely on Published Data on Potential Drug Targets?
Improving the translational hit of experimental treatments in multiple sclerosis
Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy
Why Are So Many Epidemiology Associations Inflated or Wrong? Does Poorly Conducted Animal Research Suggest Implausible Hypotheses?
Systematic Reviews of Animal Experiments Demonstrate Poor Contributions Toward Human Healthcare
A Systematic Review of Systematic Reviews and Meta-Analyses of Animal Experiments with Guidelines for Reporting
Where is the evidence that animal research benefits humans?
The reserve-capacity hypothesis: evolutionary origins and modern implications of the trade-off between tumor-suppression and tissue-repair
Evidence-Based Data From Animal and Human Experimental Studies on Pain Relief With Antidepressants: A Structured Review
Concordance of the Toxicity of Pharmaceuticals in Humans and in Animals
Induction of Drug-Metabolizing Enzymes in Liver Microsomes of Mice and Rats by Softwood Bedding
The effects of olfactory cues on the maze learning of white rats
Experiments Using Mice Are Often Heavily Publicised—But Very, Very Few of Them Translate into Humans. Anthony King Reports on Why Animal Models Are of Questionable Value.
Two Years Later: Journals Are Not Yet Enforcing the ARRIVE Guidelines on Reporting Standards for Pre-Clinical Animal Studies
Can Animal Models of Disease Reliably Inform Human Studies?
A Primer on Why Computational Predictive Toxicology Is Hard
The Mouse Trap: The Dangers of Using One Lab Animal to Study Every Disease
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Experimenters’ sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor
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