Crypto Millionaire Fuels Push to Transform Brain Research: James Fickel Has Dedicated $200 Million He Made Betting on Ether to Becoming One of the World’s Biggest Investors in Those Fields
Pervasive findings of directional selection realize the promise of ancient DNA to elucidate human adaptation
The global pattern of centenarians highlights deep problems in demography
Spatial cognitive ability is associated with longevity in food-caching chickadees
Unveiling the Epigenetic Impact of Vegan vs. Omnivorous Diets on Aging: Insights from the Twins Nutrition Study (TwiNS)
Somatic mutations in human ageing: New insights from DNA sequencing and inherited mutations
Longevity factor klotho enhances cognition in aged nonhuman primates
Premature Aging and Reduced Cancer Incidence Associated with Near-Complete Body-Wide Myc Inactivation
Late-life Rapamycin Treatment Enhances Cardiomyocyte Relaxation Kinetics and Reduces Myocardial Stiffness
Mendelian Randomization supports causality between overweight status and accelerated aging
DNA repair and anti-cancer mechanisms in the longest-living mammal: the bowhead whale
Intelligence and life expectancy in late adulthood: A meta-analysis
Age-dependent topic modeling of comorbidities in UK Biobank identifies disease subtypes with differential genetic risk
Evidence for the role of selection for reproductively advantageous alleles in human aging
Hypoxia extends lifespan and neurological function in a mouse model of aging
Five years later, with double the demographic data, naked mole-rat mortality rates continue to defy Gompertzian laws by not increasing with age
Sam Altman invested $180 million into a company trying to delay death: Can anti-aging breakthroughs add 10 healthy years to the human life span? The CEO of OpenAI is paying to find out
Loss of smelling is an early marker of aging and is associated with inflammation and DNA damage in C57BL/6J mice
Mortality postponement and compression at older ages in human cohorts
Status and mortality: Is there a Whitehall effect in the United States?
Effect of basal metabolic rate on lifespan: a sex-specific Mendelian Randomization study
Cell Tree Rings: the shape of somatic evolution as a human aging timer
Rejuvenating Senescent Cells and Organisms with Only Ultrasound
Today’s Older Adults Are Cognitively Fitter Than Older Adults Were 20 Years Ago, but When and How They Decline Is No Different Than in the Past
Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice
A cocktail of rapamycin, acarbose and phenylbutyrate prevents age-related cognitive decline in mice by altering aging pathways
Old plasma dilution reduces human biological age: a clinical study
Slow and negligible senescence among testudines challenges evolutionary theories of senescence
A hierarchical process model links behavioral aging and lifespan in C. elegans
An exercise-inducible metabolite that suppresses feeding and obesity
Clonal dynamics of hematopoiesis across the human lifespan
Mendelian Randomization of genetically independent aging phenotypes identifies LPA and VCAM1 as biological targets for human aging
Rare Genetic Variants Correlate with Better Processing Speed
Longevity, cellular senescence and the gut microbiome: lessons to be learned from crocodiles
Polygenic basis and biomedical consequences of telomere length variation
Escape of hair follicle stem cells causes stem cell exhaustion during aging
Increased somatic mutation burdens in normal human cells due to defective DNA polymerases
Lithium can mildly increase health during ageing but not lifespan in mice
Extending human healthspan and longevity: a symposium report
Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span
An aged immune system drives senescence and ageing of solid organs
Beneficial and Detrimental Effects of Reactive Oxygen Species on Lifespan: A Comprehensive Review of Comparative and Experimental Studies
Carbohydrate restriction for diabetes: rediscovering centuries-old wisdom
Effect of Vitamin D Supplementation, Omega-3 Fatty Acid Supplementation, or a Strength-Training Exercise Program on Clinical Outcomes in Older Adults: The DO-HEALTH Randomized Clinical Trial
Surprisingly long survival of premature conclusions about naked mole-rat biology
C60 in olive oil causes light-dependent toxicity and does not extend lifespan in mice
CRISPR-enhanced human adipocyte ‘browning’ as cell therapy for metabolic disease
The burden of rare protein-truncating genetic variants on human lifespan
Supercentenarian and remarkable age records exhibit patterns indicative of clerical errors and pension fraud
Was Jeanne Calment the Oldest Person Who Ever Lived—or a Fraud? Some researchers have cast doubt on the record of the celebrated supercentenarian
Vitamin D Supplementation for Prevention of Mortality in Adults
A single combination gene therapy treats multiple age-related diseases
Effect of Lower Versus Higher Red Meat Intake on Cardiometabolic and Cancer Outcomes: A Systematic Review of Randomized Trials
Exercise conditioned plasma dampens inflammation via clusterin and boosts memory
A Prospective Analysis of Genetic Variants Associated with Human Lifespan
Restoration of brain circulation and cellular functions hours post-mortem
Genetically heterogeneous mice exhibit a female survival advantage that is age-specific and site-specific: Results from a large multi-site study
Relaxed Selection Limits Lifespan by Increasing Mutation Load
An Evolutionary Perspective on Why Food Overconsumption Impairs Cognition
What Do We Need to Know to Treat Degenerative Aging As a Medical Condition to Extend Healthy Lifespan?
Effects of Intermittent Fasting on Health, Aging, and Disease
Genomic underpinnings of lifespan allow prediction and reveal basis in modern risks
Anti-aging food that improves markers of health in senior dogs by modulating gut microbiota and metabolite profiles
Quantitative analysis of population-scale family trees with millions of relatives
Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin SecretionThe DIETFITS Randomized Clinical Trial
Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men With Prediabetes
Selection for long and short sleep duration in Drosophila melanogaster reveals the complex genetic network underlying natural variation in sleep
Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity
A long journey to reproducible results: Replicating our work took four years and 100,000 worms but brought surprising discoveries
Identifying genetic variants that affect viability in large cohorts
Safe Landing Strategies During a Fall: Systematic Review and Meta-Analysis
Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling
2,4-Dinitrophenol, the inferno drug: a netnographic study of user experiences in the quest for leanness
A Hypothesis to Explain Cancers in Confined Colonies of Naked Mole Rats
Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice
Performance of informative priors skeptical of large treatment effects in clinical trials: A simulation study
Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men
Vitamin D Supplementation for Prevention of Cancer in Adults (Review)
A review of creatine supplementation in age-related diseases: more than a supplement for athletes
Reproductive Capability Is Associated with Lifespan and Cause of Death in Companion Dogs
Multivitamin-multimineral supplementation and mortality: a meta-analysis of randomized controlled trials
Sitting Time and All-Cause Mortality Risk in 222,497 Australian Adults
Melatonin in aging and disease -multiple consequences of reduced secretion, options and limits of treatment
Happy Aged People Are All Alike, While Every Unhappy Aged Person Is Unhappy in Its Own Way
Vitamin D and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis
Oral Anti-Diabetic Drugs for the Prevention of Type 2 Diabetes
Intelligence in youth and all-cause-mortality: systematic review with meta-analysis
Compression of morbidity 1980–2011: a focused review of paradigms and progress
Association of circulating visfatin concentrations with insulin resistance and low-grade inflammation after dietary energy restriction in Spanish obese non-diabetic women: Role of body composition changes
Plasma Vitamin D and Mortality in Older Men: a Community-Based Prospective Cohort Study
Good Semen Quality and Life Expectancy: A Cohort Study of 43,277 Men
Factors Contributing to the Facial Aging of Identical Twins
Use of Supplements of Multivitamins, Vitamin C, and Vitamin E in Relation to Mortality
Effects of Calcium and Vitamin D Supplementation on Hip Bone Mineral Density and Calcium-Related Analytes in Elderly Ambulatory Australian Women: A Five-Year Randomized Controlled Trial
A Randomized, Controlled Trial of Quadriceps Resistance Exercise and Vitamin D in Frail Older People: The Frailty Interventions Trial in Elderly Subjects (FITNESS)
The reserve-capacity hypothesis: evolutionary origins and modern implications of the trade-off between tumor-suppression and tissue-repair
Book Review: _Validation of Exceptional Longevity: by Bernard Jeune and James W. Vaupel
Prevention of Femoral and Lumbar Bone Loss with Hormone Replacement Therapy and Vitamin D3 in Early Postmenopausal Women: A Population-Based 5–Year Randomized Trial
Association of Neurocognitive and Physical Function With Gait Speed in Midlife Neurology
Low-Dose Lithium Uptake Promotes Longevity in Humans and Metazoans
Computational Analysis of Lifespan Experiment Reproducibility
James F. Fries, Who Studied the Good Life and How to Live It, Dies at 83
Dietary Magnesium Intake Is Inversely Associated With Mortality in Adults at High Cardiovascular Disease Risk
J’accuse...! Why Jeanne Calment’s 122-Year Old Longevity Record May Be Fake
More Evidence for Jeanne Calment’s Identity Theft Hypothesis
2023-singh-figure1-graphicalabstractoftaurinebenefitsforlifeextensioninwormmiceandhumans.jpg
2016-hochberg-figure1-nakedmoleratsurvivalcurvesinwildvscaptivity.jpg
https://www.reuters.com/article/uk-greece-benefits/greece-pulls-the-plug-on-pensions-for-the-dead-idUKBRE83O14220120425/
2009-guyuron-figure10-effectofalcoholadvoidanceonfacialagedifferenceinidenticaltwins.jpg
2009-guyuron-figure3-effectofsmokingonfacialaginginpairsofidenticaltwins.jpg
2009-guyuron-figure4-smokingtwinlooksolderthanlesssmokingidenticaltwin.jpg
2009-guyuron-figure5-smokingtwinlooksolderthanlesssmokingidenticaltwinmales.png
2009-guyuron-figure6-identicaltwinsdiscordantinsunexposureandbmiagedifference.jpg
2009-guyuron-figure7-identicaltwinsdiscordantinsunexposureandhormonetherapyagedifference.jpg
2004-04-12-sage-leonkass-agelessbodiesandhappysoulsinterview.html
1977-friedman-proteincrosslinkingnutritionalandmedicalconsequences.pdf
gwern-gompertzcurve-longevity-calmentcasestudy-unsorted.png
https://gravityandlevity.wordpress.com/2009/07/08/your-body-wasnt-built-to-last-a-lesson-from-human-mortality-rates/
https://journals.sagepub.com/doi/10.1177/17456916231204811
https://link.springer.com/article/10.1007/s11357-023-00818-1
https://loyalfordogs.com/posts/loyal-announces-historic-fda-milestone-for-large-dog-lifespan-extension-drug
https://thelampmagazine.com/issues/issue-17/shadow-on-the-sun
https://trevorklee.substack.com/p/is-longevity-a-choice-how-about-obesity
https://vmc.vet.osu.edu/cto/clinical-trials/rapamycin-cats-chronic-kidney-disease
https://worksinprogress.co/issue/the-future-of-kidney-treatment/
https://www.bloomberg.com/news/features/2023-01-25/anti-aging-techniques-taken-to-extreme-by-bryan-johnson
https://www.demographic-research.org/volumes/vol40/29/40-29.pdf
https://www.demographic-research.org/volumes/vol49/27/49-27.pdf
https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2021.722187/full
https://www.sciencedirect.com/science/article/pii/S0047637419300181
https://www.statnews.com/2022/08/09/anti-aging-projects-funding-much-discussed-trial-overlooked/
https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00189-7/fulltext
https://www.theonion.com/world-death-rate-holding-steady-at-100-percent-1819564171
https://www.wired.com/story/patricia-moore-sacrificed-youth-to-get-tech-bros-to-grow-up/
Sam Altman invested $180 million into a company trying to delay death: Can anti-aging breakthroughs add 10 healthy years to the human life span? The CEO of OpenAI is paying to find out
https%253A%252F%252Fwww.technologyreview.com%252F2023%252F03%252F08%252F1069523%252Fsam-altman-investment-180-million-retro-biosciences-longevity-death%252F.html
Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice
https%253A%252F%252Fonlinelibrary.wiley.com%252Fdoi%252F10.1111%252Facel.13724.html
Old plasma dilution reduces human biological age: a clinical study
https%253A%252F%252Flink.springer.com%252Farticle%252F10.1007%252Fs11357-022-00645-w.html
Mendelian Randomization of genetically independent aging phenotypes identifies LPA and VCAM1 as biological targets for human aging
Kamatani Laboratory (Laboratory of Complex Trait Genomics)
Professor Yukinori Okada, Department of Statistical Genetics, Graduate School of Medicine － Osaka University
https%253A%252F%252Fwww.nature.com%252Farticles%252Fs43587-021-00159-8.html
Selection for long and short sleep duration in Drosophila melanogaster reveals the complex genetic network underlying natural variation in sleep
https%253A%252F%252Fjournals.plos.org%252Fplosgenetics%252Farticle%253Fid%253D10.1371%252Fjournal.pgen.1007098.html
https%253A%252F%252Fwww.sciencedirect.com%252Fscience%252Farticle%252Fpii%252FS0092867405001017.html
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