The Immune System Can Sabotage Gene Therapies—Can Scientists Rein It In?
After CRISPR baby scandal shut down work for years, China gene editing companies are restarting clinical trials
Design of highly functional genome editors by modeling the universe of CRISPR-Cas sequences
Encapsulation of AAVs into protein vault nanoparticles as a novel solution to gene therapy’s neutralizing antibody problem
AAV1-hOTOF gene therapy for autosomal recessive deafness 9: a single-arm trial
Robotic Microinjection Enables Large-Scale Transgenic Studies of Caenorhabditis Elegans
Cryptography in the DNA of living cells enabled by multi-site base editing
A Pooled Cell Painting CRISPR Screening Platform Enables de novo Inference of Gene Function by Self-supervised Deep Learning
GDNF gene therapy for alcohol use disorder in male non-human primates
In vivo biosynthesis of N,N-dimethyltryptamine, 5-MeO-N,N-dimethyltryptamine, and bufotenine in E. coli
Temperature-dependent RNA editing in octopus extensively recodes the neural proteome
The First Crispr-Edited Salad Is Here: A startup used gene editing to make mustard greens more appetizing to consumers. Next up: fruits
First gene-edited calf with reduced susceptibility to a major viral pathogen
Acceptance of genetic editing and of whole genome sequencing of human embryos by patients with infertility before and after the onset of the COVID-19 pandemic
CRISPR technology: A decade of genome editing is only the beginning
Gene Therapy Mediated Partial Reprogramming Extends Lifespan and Reverses Age-Related Changes in Aged Mice
Base editing: Revolutionary therapy clears girl’s incurable cancer
MicroRNAs are deeply linked to the emergence of the complex octopus brain
PASTE: Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases
Large scale functional screen identifies genetic variants with splicing effects in modern and archaic humans
Prime editing for precise and highly versatile genome manipulation
Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1 Omicron
New self-sexing Aedes aegypti strain eliminates barriers to scalable and sustainable vector control for governments and communities in dengue-prone environments
RNA recoding in cephalopods tailors microtubule motor protein function
A sustainable mouse karyotype created by programmed chromosome fusion
CRISPR-Cas9-mediated gene editing of the BCL11A enhancer for pediatric β0/β0 transfusion-dependent β-thalassemia
A versatile, high-efficiency platform for CRISPR-based gene activation
Generation of genome-edited dogs by somatic cell nuclear transfer
Retro-Cascorder: Recording gene expression order in DNA by CRISPR addition of retron barcodes
Genome-edited crops for improved food security of smallholder farmers
The creator of the CRISPR babies has been released from a Chinese prison: He Jiankui created the first gene-edited children. The price was his career. And his freedom.
A CRISPR Kitty? Gene Editing Breathes New Life into the Hypoallergenic Cat
Virgin Birth: A genetic basis for facultative parthenogenesis
Viable offspring derived from single unfertilized mammalian oocytes
How to protect the first ‘CRISPR babies’ prompts ethical debate: Fears of excessive interference cloud proposal for protecting children whose genomes were edited, as He Jiankui’s release from jail looks imminent
In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue
The gene TaWOX5 overcomes genotype dependency in wheat genetic transformation
Biologic and Clinical Efficacy of LentiGlobin for Sickle Cell Disease
CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes
Lipid nanoparticles incorporating a GalNAc ligand enable in vivo liver ANGPTL3 editing in wild-type and somatic LDLR knockout non-human primates
A temporally resolved, multiplex molecular recorder based on sequential genome editing
Multiplex genomic recording of enhancer and signal transduction activity in mammalian cells
Drag-and-drop genome insertion without DNA cleavage with CRISPR-directed integrases
PRIME-Del: Precise genomic deletions using paired prime editing
PEDAR: Deletion and replacement of long genomic sequences using prime editing
In a First, Surgeons Attached a Pig Kidney to a Human, and It Worked: A kidney grown in a genetically altered pig functions normally, scientists reported. The procedure may open the door to a renewable source of desperately needed organs
The widespread IS200/605 transposon family encodes diverse programmable RNA-guided endonucleases
Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery
Gene-drive suppression of mosquito populations in large cages as a bridge between lab and field
RNA demethylation increases the yield and biomass of rice and potato plants in field trials
Surrogate broodstock to enhance biotechnology research and applications in aquaculture
CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis
Base editing of haematopoietic stem cells rescues sickle cell disease in mice
Scientists Drove Mice to Bond by Zapping Their Brains With Light: The study, a tour de force in bioengineering, comes after two decades of research on brain-to-brain synchrony in people
Partial recovery of visual function in a blind patient after optogenetic therapy
With engineered proteins, scientists use optogenetics for the first time to help a blind patient see again
In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
High-throughput functional variant screens via in vivo production of single-stranded DNA
First genetically modified mosquitoes released in the United States: Biotech firm Oxitec launches controversial field test of its insects in Florida after years of push-back from residents and regulatory complications
Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing
China officially bans CRISPR babies, human clones and animal-human hybrids
Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment
Reactivation of the pluripotency program precedes formation of the cranial neural crest
In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice
Expression of functional plant sweet protein thaumatin II in the milk of transgenic mice
Xenogeneic stem cell transplantation: Research progress and clinical prospects
Human-animal interspecies chimerism via blastocyst complementation: advances, challenges and perspectives: a narrative review
Reconstitution of the oocyte transcriptional network with transcription factors
Biotechnology Research Viewed With Caution Globally, but Most Support Gene Editing for Babies To Treat Disease: Majorities across global publics accept evolution; religion factors prominently in belief
Reprogramming to recover youthful epigenetic information and restore vision
Inclusion of variants discovered from diverse populations improves polygenic risk score transferability
Recency negativity: Newer food crops are evaluated less favorably
CRISPR-enhanced human adipocyte ‘browning’ as cell therapy for metabolic disease
Human Embryo Gene Editing Gets a Road Map—Not a Green Light: After the 2018 ‘Crispr baby’ scandal, a global commission assessed the technology and set strict criteria for moving it toward clinical trials
CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice
Human-specific ARHGAP11B increases size and folding of primate neocortex in the fetal marmoset
Cas9 Cuts and Consequences; Detecting, Predicting, and Mitigating CRISPR/Cas9 On-Target and Off-Target Damage [Techniques for Detecting, Predicting, and Mitigating the On-Target and Off-Target Effects of Cas9 Editing]
A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing
A Year In, 1st Patient To Get Gene Editing For Sickle Cell Disease Is Thriving
Three people with inherited diseases successfully treated with CRISPR
CRISPR-Cas9-mediated induction of heritable chromosomal translocations in Arabidopsis
Generation of human endothelium in pig embryos deficient in ETV2
Metabolic engineering of Saccharomyces cerevisiae for the de novo production of psilocybin and related tryptamine derivatives
Chinese Scientist Who Genetically Edited Babies Gets 3 Years in Prison: He Jiankui’s work was also carried out on a third infant, according to China’s state media, in a new disclosure that is likely to add to the global uproar over such experiments.
Eyeing organs for human transplants, companies unveil the most extensively gene-edited pigs yet
A single combination gene therapy treats multiple age-related diseases
Search-and-replace genome editing without double-strand breaks or donor DNA
A New Crispr Technique Could Fix Almost All Genetic Diseases: A less error-prone DNA editing method could correct many more harmful mutations than was previously possible
Technological challenges and milestones for writing genomes: Synthetic genomics requires improved technologies
CRISPR-Edited Stem Cells in a Patient With HIV and Acute Lymphocytic Leukemia
The Promise and Price of Cellular Therapies: New ‘living drugs’—made from a patient’s own cells—can cure once incurable cancers. But can we afford them?
Russian biologist plans more CRISPR-edited babies: The proposal follows a Chinese scientist who claimed to have created twins from edited embryos last year
Exclusive: 5 couples lined up for CRISPR babies to avoid deafness
Amid animal cruelty debate, 80% of South Korea’s sniffer dogs are cloned
When genome editing goes off-target: Detecting unintended mutations could improve DNA-editing strategies
Enabling large-scale genome editing by reducing DNA nicking
Super-Mendelian inheritance mediated by CRISPR-Cas9 in the female mouse germline
The transferability of lipid-associated loci across African, Asian and European cohorts
Improving crop yield: Synthetic photorespiration bypass increases crop yield
Is the ‘serious’ factor in germline modification really relevant? A response to Kleiderman, Ravitsky and Knoppers
Transgenic Metarhizium rapidly kills mosquitoes in a malaria-endemic region of Burkina Faso
Synthetic glycolate metabolism pathways stimulate crop growth and productivity in the field
Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos
Radical Technology Meets Radical Application: An Interview With George Church
A DNA-Of-Things Storage Architecture to Create Materials With Embedded Memory
Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq
Analysis of Polygenic Score Usage and Performance across Diverse Human Populations
In Vivo CRISPR Editing With No Detectable Genome-Wide Off-Target Mutations
Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy
Accurate Classification of BRCA1 Variants With Saturation Genome Editing
Genome-Edited Skin Epidermal Stem Cells Protect Mice from Cocaine-Seeking Behavior and Cocaine Overdose
Reprogramming Human T Cell Function and Specificity With Non-Viral Genome Targeting
Refining the Accuracy of Validated Target Identification through Coding Variant Fine-Mapping in Type 2 Diabetes
In utero CRISPR-mediated therapeutic editing of metabolic genes
Livestock 2.0—genome editing for fitter, healthier, and more productive farmed animals
Karyotype engineering by chromosome fusion leads to reproductive isolation in yeast
Chinese firm clones gene-edited dog in bid to treat cardiovascular disease
Polygenic prediction of the phenome, across ancestry, in emerging adulthood
Quantification of frequency-dependent genetic architectures and action of negative selection in 25 UK Biobank traits
Genome-wide association study identifies 112 new loci for body mass index in the Japanese population
Linkage disequilibrium-dependent architecture of human complex traits shows action of negative selection
Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9
Comparing distributions of polygenic risk scores of type 2 diabetes and coronary heart disease within different populations
Nanoparticle Delivery of Cas9 Ribonucleoprotein and Donor DNA in Vivo Induces Homology-Directed DNA Repair
Implications of Human Genetic Variation in CRISPR-Based Therapeutic Genome Editing
CRISPR/Cas9-Mediated Gene Editing in Human Zygotes Using Cas9 Protein
In Vivo Excision of HIV-1 Provirus by SaCas9 and Multiplex Single-Guide RNAs in Animal Models
Generation of human organs in pigs via interspecies blastocyst complementation
Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli
Introducing Precise Genetic Modifications into Human 3PN Embryos by CRISPR/Cas-Mediated Genome Editing
High-Fidelity CRISPR–Cas9 Nucleases With No Detectable Genome-Wide Off-Target Effects
Schizophrenia Risk from Complex Variation of Complement Component 4
Gene-Edited Pigs Are Protected from Porcine Reproductive and Respiratory Syndrome Virus
Therapeutic Genome Editing by Combined Viral and Non-Viral Delivery of CRISPR System Components in Vivo
In Vivo CRISPR/Cas9 Gene Editing Corrects Retinal Dystrophy in the S334ter-3 Rat Model of Autosomal Dominant Retinitis Pigmentosa
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
RNA-guided gene drives can efficiently and reversibly bias inheritance in wild yeast
Proxy-Phenotype Method Identifies Common Genetic Variants Associated with Cognitive Performance
Update on the First Cloned Dog and Outlook for Canine Cloning
Genome editing. The mutagenic chain reaction: a method for converting heterozygous to homozygous mutations
Chromosome transplantation as a novel approach for correcting complex genomic disorders
One Hundred Years of Statistical Developments in Animal Breeding
The Deleterious Mutation Load Is Insensitive to Recent Population History
A novel BHLHE41 variant is associated with short sleep and resistance to sleep deprivation in humans
Simultaneous Editing of 3 Homoeoalleles in Hexaploid Bread Wheat Confers Heritable Resistance to Powdery Mildew
Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT)
Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype
Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases
A competitive advantage by neonatally engrafted human glial progenitors yields mice whose brains are chimeric for human glia
Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA
Generalization and Dilution of Association Results from European GWAS in Populations of Non-European Ancestry: The PAGE Study
Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients
Efficient genome editing in zebrafish using a CRISPR-Cas system
Efficient Nonmeiotic Allele Introgression in Livestock Using Custom Endonucleases
Heritability of performance deficit accumulation during acute sleep deprivation in twins
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
Conversion of Mouse Fibroblasts into Cardiomyocytes Using a Direct Reprogramming Strategy
The transcriptional repressor DEC2 regulates sleep length in mammals
Genetically modified Streptococcus mutans for the prevention of dental caries
Genetic Manipulation in Humans as a Matter of Rawlsian Justice
Potential of Gene Drives With Genome Editing to Increase Genetic Gain in Livestock Breeding Programs
Some Thoughts on Education and Political Priorities, Cummings 2013
A Sleep Diary and Questionnaire Study of Naturally Short Sleepers
One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering
China’s Bold Push into Genetically Customized Animals: New Kinds of Dogs, Goats and Monkeys Are Being Made Quickly, Although Scientists Voice Worries about Ethics and Whether the Methods Should Be Used on Humans
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https%253A%252F%252Fwww.wired.com%252Fstory%252Fpink-pineapples-grocery-store-pinkglow-genetically-modified%252F.html
After CRISPR baby scandal shut down work for years, China gene editing companies are restarting clinical trials
https%253A%252F%252Fendpts.com%252Fafter-crispr-baby-scandal-shut-down-work-for-years-china-gene-editing-companies-are-restarting-clinical-trials%252F.html
In vivo biosynthesis of N,N-dimethyltryptamine, 5-MeO-N,N-dimethyltryptamine, and bufotenine in E. coli
Temperature-dependent RNA editing in octopus extensively recodes the neural proteome
https%253A%252F%252Fwww.cell.com%252Fcell%252Ffulltext%252FS0092-8674%252823%252900523-8.html
The First Crispr-Edited Salad Is Here: A startup used gene editing to make mustard greens more appetizing to consumers. Next up: fruits
https%253A%252F%252Fwww.wired.com%252Fstory%252Fwired30-crispr-edited-salad-greens%252F.html
Gene Therapy Mediated Partial Reprogramming Extends Lifespan and Reverses Age-Related Changes in Aged Mice
https%253A%252F%252Fwww.biorxiv.org%252Fcontent%252F10.1101%252F2023.01.04.522507.full.html
New self-sexing Aedes aegypti strain eliminates barriers to scalable and sustainable vector control for governments and communities in dengue-prone environments
https%253A%252F%252Fwww.frontiersin.org%252Farticles%252F10.3389%252Ffbioe.2022.975786%252Ffull.html
A sustainable mouse karyotype created by programmed chromosome fusion
%252Fdoc%252Fgenetics%252Fediting%252F2022-wang-5.pdf.html
Generation of genome-edited dogs by somatic cell nuclear transfer
https%253A%252F%252Fbmcbiotechnol.biomedcentral.com%252Farticles%252F10.1186%252Fs12896-022-00749-3.html
Genome-edited crops for improved food security of smallholder farmers
%252Fdoc%252Fgenetics%252Fediting%252F2022-pixley.pdf.html
The gene TaWOX5 overcomes genotype dependency in wheat genetic transformation
When genome editing goes off-target: Detecting unintended mutations could improve DNA-editing strategies
%252Fdoc%252Fgenetics%252Fediting%252F2019-kempton.pdf.html
Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos
