“Schizophrenia Polygenic Risk Score and Long-Term Success in the Labour Market: A Cohort Study”, Jutta Viinikainen, Petri Böckerman, Christian Hakulinen, Jaana T. Kari, Terho Lehtimäki, Olli T. Raitakari, Jaakko Pehkonen2022-05-26 (economics, SCZ)⁠:

Employment is rare among people with a schizophrenia diagnosis. Meanwhile, a genetic liability for schizophrenia may hinder labour market performance.

We studied how the polygenic risk score (PGS) for schizophrenia related to education and labour market outcomes.

We found that a higher PGS was linked to lower educational levels and weaker labour market outcomes as well as a higher likelihood of receiving social income transfers, particularly among men.

Assuming that the link is causal, our results indicate that individuals with schizophrenia or schizophrenia-related traits have a weakened ability to fully participate in the labour market, potentially reinforcing social exclusion.

[Keywords: schizophrenia, polygenic risk score, education, earnings, employment, social income transfers]