“Fel D 1 Blocking Antibodies: A Novel Method to Reduce IgE-Mediated Allergy to Cats”, 2021 (; backlinks):
Fel d 1 is an important allergen produced by cats that causes IgE reactions in up to 95% of cat-allergic adults. Immunotherapy to reduce human allergy to cats has demonstrated that people have the capacity to produce allergen-specific neutralizing antibodies that block IgE-mediated allergic responses. We wished to determine if “blocking” antibodies could be used to reduce the IgE binding ability of cat allergens prior to their exposure to humans.
Here, we describe the characterization of Fel d 1-specific antibodies. We demonstrated the efficacy of a rabbit polyclonal and an allergen-specific chicken IgY to bind to Fel d 1 in cat saliva and block Fel d 1-IgE binding and IgE-mediated basophil degranulation.
Fel d 1 blocking antibodies offer a new and exciting approach to the neutralization of cat allergens.