“Shared Polygenic Contribution between Childhood Attention-Deficit Hyperactivity Disorder and Adult Schizophrenia”, 2013 (; backlinks; similar):
Background: There is recent evidence of some degree of shared genetic susceptibility between adult schizophrenia and childhood attention-deficit hyperactivity disorder (ADHD) for rare chromosomal variants.
Aims: To determine whether there is overlap between common alleles conferring risk of schizophrenia in adults with those that do so for ADHD in children.
Method: We used recently published Psychiatric Genome-wide Association Study (GWAS) Consortium (PGC) adult schizophrenia data to define alleles over-represented in people with schizophrenia and tested whether those alleles were more common in 727 children with ADHD than in 2067 controls.
Results: Schizophrenia risk alleles discriminated ADHD cases from controls (p = 1.04 × 10−4, R(2) = 0.45%); stronger discrimination was given by alleles that were risk alleles for both adult schizophrenia and adult bipolar disorder (also derived from a PGC data-set) (p = 9.98 × 10−6, R(2) = 0.59%).
Conclusion: This increasing evidence for a small, but, shared genetic susceptibility between adult schizophrenia and childhood ADHD highlights the importance of research work across traditional diagnostic boundaries.