“Modafinil Effects on Cognitive Function in HIV+ Patients Treated for Fatigue: a Placebo Controlled Study”, 2010 (; backlinks; similar):
Both mild cognitive impairment and fatigue are common among people with HIV/AIDS.
This study examined the efficacy of modafinil for HIV+ patients who sought treatment for fatigue in a placebo-controlled double-blind 4-week trial. A battery of standard neuropsychological tests was administered at study entry and Week 4, and change in performance was compared for 59 patients receiving modafinil versus 44 patients receiving placebo.
A statistically-significant effect on fatigue was observed. In addition, cognitive performance, as measured by a global change score, improved more in the modafinil than in the placebo group although the effect was not specific to any cognitive domain.