“The Economic Value of Targeting Aging”, Andrew J. Scott, Martin Ellison, David A. Sinclair2021-07-05 (; backlinks; similar)⁠:

Developments in life expectancy and the growing emphasis on biological and ‘healthy’ aging raise a number of important questions for health scientists and economists alike. Is it preferable to make lives healthier by compressing morbidity, or longer by extending life? What are the gains from targeting aging itself compared to efforts to eradicate specific diseases? Here we analyze existing data to evaluate the economic value of increases in life expectancy, improvements in health and treatments that target aging.

We show that a compression of morbidity that improves health is more valuable than further increases in life expectancy, and that targeting aging offers potentially larger economic gains than eradicating individual diseases. We show that a slowdown in aging that increases life expectancy by 1 year is worth US$38 trillion, and by 10 years, US$367 trillion.

Ultimately, the more progress that is made in improving how we age, the greater the value of further improvements.

Figure 2: willingness-to-pay (WTP) by year of life for metformin treatment started at age 75. The value for each year (by age) of improvements in the incidence of various diseases under simulated impact of metformin. Sum of separate effects, the total of each individual effect; Total effect, the overall value for each year of health improvements attributed to metformin. Solid lines represent WTP for each of the 5 comorbidities separately.

…The economic value of gains from targeting aging are large because delaying aging produces complementarities between health and longevity, affect a large number of diseases due to the rising prevalence of age-related comorbidities, and create synergies arising from competing risks. Crucially, delaying aging leads to a virtuous circle in which slowing aging begets demand for further slowing in aging. This virtuous circle arises because society’s gains from delaying aging rise with the average age of society, increase with the quality of life in old age, and depend on the number of older people. This provides a distinctive dynamic to targeting aging compared to treatments aimed at specific diseases, in which gains diminish once successful treatments are discovered.