“Old Plasma Dilution Reduces Human Biological Age: a Clinical Study”, 2022-08-24 ():
This work extrapolates to humans the previous animal studies on blood heterochronicity [young blood transfusion/parabiosis] and establishes a novel direct measurement of biological age.
Our results support the hypothesis that, similar to mice, human aging is driven by age-imposed systemic molecular excess, the attenuation of which reverses biological age, defined in our work as a deregulation (noise) of 10 novel protein biomarkers. [a pilot study (~10 real test subjects, proteomics from 47 people, ~350 mRNA samples)]
The results on biological age are strongly supported by the data, which demonstrates that rounds of therapeutic plasma exchange (TPE) promote a global shift to a younger systemic proteome, including youthfully restored pro-regenerative, anticancer, and apoptotic regulators and a youthful profile of myeloid/lymphoid markers in circulating cells, which have reduced cellular senescence and lower DNA damage. Mechanistically, the circulatory regulators of the JAK-STAT, MAPK, TGF-beta, NF-κB, and Toll-like receptor signaling pathways become more youthfully balanced through normalization of TLR4, which we define as a nodal point of this molecular rejuvenation.
The importance of our findings is confirmed through big-data gene expression studies.