“Timing Technology: Lessons From The Media Lab § Reverse Salients”, Gwern2012-07-12 (, , , , , , )⁠:

Technological developments can be foreseen but the knowledge is largely useless because startups are inherently risky and require optimal timing. A more practical approach is to embrace uncertainty, taking a reinforcement learning perspective.

Excerpts from The First Miracle Drugs: How the Sulfa Drugs Transformed Medicine, John Lesch 200618ya.

They describe Heinrich Hörlein’s drug development programs & Thomas Edison’s electrical programs as being strategically aimed at opportunities called “reverse salients”, taking necessary steps to solve bottlenecks which hold back the practical application of progress in areas. Such targeted research efforts can have disproprotionate payoffs and lead to sudden breakthroughs as the ‘enemy’s frontline’ collapses.