“LSD Microdosing RCT”, Gwern2012-08-20 (R, SR1 DNM, interview, LSD microdosing, QS, writing psychology, power analysis, forecasting; backlinks)⁠:

Self-experiment with sub-psychedelic doses of LSD; no benefit

Some early experimental studies with LSD suggested that doses of LSD too small to cause any noticeable effects may improve mood and creativity. Prompted by recent discussion of this claim and the purely anecdotal subsequent evidence for it, I decided to run a well-powered randomized blind trial of 3-day LSD microdoses from September 2012_12ya to March 2013_11ya. No beneficial effects reached statistical-significance and there were worrisome negative trends. LSD microdosing did not help me.

• Background
• Microdosing
• Experiment
  • Design
  • Limitations
    • Validity
    • Dosage
      • Any
      • Useful Dose?
    • Degradation
  • Power Calculation
  • VoI
  • Data
  • Fadiman Comments
  • Analysis
    • Preparation
    • Blinding
    • Graphing Data
    • Testing the Metrics
    • Conclusion
      • Source Code
    • Microdose Effect Length
• External Links
• Appendices
  • Trip Report
    • Other Comments

Backlinks: