“Hyponatraemia and Cerebral Oedema due to a Modafinil Overdose”, 2020-07-05 (; backlinks):
Modafinil is a non-amphetamine stimulant that is prescribed for narcolepsy-associated sleepiness as well as reported off-license uses among university students looking to improve wakefulness and focus.
There is limited information in the medical literature about supratherapeutic modafinil dosage, symptomatology, and management of overdose.
We report a case of a healthy 32-year-old man who was found unconscious, having vomited, with an empty modafinil blister strip. At the emergency department, he presented with reduced Glasgow Coma Scale and prolonged episodes of vomiting.
This acute presentation was conservatively managed in the intensive care unit. Antibiotics were also given for a suspected aspiration pneumonia. CT of the head showed cerebral edema, and biochemistry investigations revealed hyponatremia.
Result etiology was unclear, however, it has been theorized to be secondary to a sizeable modafinil overdose.