“Polycystic Ovary Syndrome, Personality, and Depression: A Twin Study”, 2017-11-01 ():
Women with PCOS had a 2-fold increase in odds for lifetime MDD.
Women with PCOS score higher on Neuroticism scale.
There are common genetic factors between neuroticism, PCOS, and MDD.
Neuroticism contributes to a portion of the comorbidity between PCOS and MDD.
Background: Women with polycystic ovary syndrome (PCOS) are at elevated risk for suffering from depression. Neuroticism is a personality trait that has been associated with an increased risk for developing major depressive disorder (MDD). The aim of the present study was to quantify and decompose the correlation between Neuroticism, PCOS, and MDD into shared and unique genetic and environmental etiologies, by using quantitative genetic methods.
Method: In a cohort of 12,628 Swedish female twins born 1959–26198539ya, Neuroticism, PCOS identified by symptoms of hyperandrogenemia (ie. hirsutism) and oligoovulation and/or anovulation, and lifetime MDD status were determined through questionnaire responses. Structural equation modeling was used to study the genetic and environmental sources of the variation within, and covariation between Neuroticism, PCOS, and MDD.
Results: Female twins with PCOS (n = 752) had statistically-significantly higher levels of Neuroticism than women without PCOS, and a 2-fold increase in odds for a lifetime prevalence of MDD. The phenotypic correlation between PCOS and MDD was 0.19, with 63% of the correlation attributable to common genetic factors between the 2 traits. When taking into account Neuroticism, 41% was attributable to common genetic factors and 9% attributable to common environmental factors shared between all 3 traits, with the remainder attributable to components unique to PCOS and MDD.
Conclusion: There are common genetic factors between Neuroticism, PCOS, and MDD; however, Neuroticism shares ~half of the genetic and environmental components behind the phenotypic correlation between PCOS and MDD, providing some etiological evidence behind the comorbidity between PCOS and depression.
[Keywords: polycystic ovary syndrome, depression, personality, Neuroticism, twins, genetic correlation]