“Identification of 15 Genetic Loci Associated With Risk of Major Depression in Individuals of European Descent”, 2016-08-01 (; backlinks; similar):
Despite strong evidence supporting the heritability of major depressive disorder (MDD), previous genome-wide studies were unable to identify risk loci among individuals of European descent.
We used self-report data from 75,607 individuals reporting clinical diagnosis of depression and 231,747 individuals reporting no history of depression through 23andMe and carried out meta-analysis of these results with published MDD genome-wide association study results.
We identified 5 independent variants from 4 regions associated with self-report of clinical diagnosis or treatment for depression. Loci with a p value <1.0 × 10−5 in the meta-analysis were further analyzed in a replication data set (45,773 cases and 106,354 controls) from 23andMe. A total of 17 independent SNPs from 15 regions reached genome-wide statistical-significance after joint analysis over all 3 data sets.
Some of these loci were also implicated in genome-wide association studies of related psychiatric traits.
These studies provide evidence for large-scale consumer genomic data as a powerful and efficient complement to data collected from traditional means of ascertainment for neuropsychiatric disease genomics.