“Velogenetics, or the Synergistic Use of Marker Assisted Selection and Germ-Line Manipulation”, 1991 (; backlinks; similar):
Until recently, artificial selection has relied on the biometrical evaluation of individual breeding values from an animal’s own performance and from performance of its relatives. This biometrical strategy is based on relatively simple genetic premises, operating within a “black box”. Briefly, the majority of economically important traits are so-called complex or quantitative traits, meaning that the phenotype of an animal is determined by both environment and a large number of genes with individually small, additive effects. The proportion of the phenotypic variation observed in a given population that is genetic in nature is the heritability of the trait. Substantial genetic progress has been obtained using this approach. One of the powers of the biometrical approach is that it obviates the need for any detailed molecular knowledge of the underlying genes or Economic Trait Loci (ETL).
However, it is believed that the molecular identification of these BTLs should allow for an increased genetic response by affecting both time and accuracy of selection, through a procedure called Marker Assisted Selection (MAS) (1,2). Moreover, we propose to use a scheme that we call “velogenetics”, or the combined use of Marker Assisted Selection and germ-line manipulations aimed at shortening the generation interval of domestic species (especially cattle), which would allow the efficient introgression of mapped Economic Trait Loci between genetic backgrounds.