“From the Concept of Totipotency to Biofortified Cereals”, 2015-04-01 (; similar):
I was a college teacher when opportunity opened a path into academia. A fascination with totipotency channeled me into research on tissue culture. As I was more interested in contributions to food security than in scientific novelty, I turned my attention to the development of genetic modification technology for cereals. From my cell culture experience, I had reasons not to trust Agrobacterium for that purpose, and I developed direct gene transfer instead.
In the early 1990s, I became aware of the problem of micronutrient deficiency, particularly vitamin A deficiency in rice-eating populations. Golden Rice, which contains increased amounts of provitamin A, was probably instrumental for the concept of biofortification to take off.
I realized that this rice would remain an academic exercise if product development and product registration were not addressed, and this is what I focused on after my retirement.
Although progress is slowly being made, had I known what this pursuit would entail, perhaps I would not have started. Hopefully Golden Rice will reach the needy during my lifetime.
[Keywords: Golden Rice, biofortification, genetic engineering, public good, GMO regulation, autobiography]