“A Human Parthenogenetic Chimera”, 1995-10-01 ():
In mice, parthenogenetic embryos die at the early post-implantation stage as a result of developmental requirements for paternally imprinted genes, particularly for formation of extra-embryonic tissues. Chimeric parthenogenetic ↔︎ normal mice are viable, however, due to non-random differences in distribution of their 2 cell types.
Species differences in imprinting patterns in embryo and extra-embryonic tissues mean that there are uncertainties in extrapolating these experimental studies to humans.
Here, however, we demonstrate that parthenogenetic chimerism can indeed result in viable human offspring, and:
suggest possible mechanisms of origin for this presumably rare event.
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