“Feeding Cats Egg Product With Polyclonal-Anti-Fel D 1 Antibodies Decreases Environmental Fel D 1 and Allergic Response: A Proof of Concept Study”, 2021-01-11 ():
Background: Cat allergens are a major contributor to environmental allergens’ overall burden, but efforts to reduce cat allergens are often unsuccessful.
Objective: To determine whether feeding cats a diet containing an egg product with anti-Fel d 1 IgY would produce clinically relevant reductions in allergy symptoms of human subjects.
Method: Following a priming exposure to blankets used for cat bedding, human subjects were subsequently exposed to environmental chambers primed with blankets from cats fed either a control diet or a test diet containing an egg product with polyclonal anti-Fel d 1 IgY. 8 cats: 5 neutered male and 3 spayed females were used. Total Nasal Symptom Score and Total Ocular Symptom Score were assessed at regular intervals. Subjects were randomly exposed to the control or test condition on the first exposure and the opposite condition on the second exposure.
Results: The levels of immunologically active Fel d 1 in chambers with blankets from cats fed the test diet were lower than those from control cats, and human subjects exposed to this condition showed statistically-significantly lower Total Nasal Symptom Scores and improvement in some ocular symptoms.
Conclusion: Fel d 1 levels in the environment are statistically-significantly decreased by feeding cats a diet containing egg product with polyclonal anti-Fel d 1 IgY. This decrease in allergen results in a statistically-significant in total nasal symptom scores and some ocular symptoms.
[Keywords: cat allergy, Fel d 1, IgY, cat dander, allergy, allergen exposure, cat]