“Efficacy of Cyclosporine for Chronic, Refractory Stomatitis in Cats: A Randomized, Placebo-Controlled, Double-Blinded Clinical Study”, 2013-03-01 ():
16 cats with chronic stomatitis, that had previously undergone premolar-molar or full-mouth extractions, were randomly assigned a group to receive 2.5 mg/kg cyclosporine or placebo orally twice daily. Neither the clinician nor the clients were aware of the group assignments.
Cats were evaluated prior to treatment and every 2 weeks for 6 weeks using a 30 point Stomatitis Disease Activity Index (SDAI) score. Mean improvement in SDAI scores among cats in the treatment group after 6 weeks was 52.7%. This was significantly different from the mean improvement (12.2%) of cats in the placebo group.
During the 6 week study period, 7 of the 9 cats in the treatment group (77.8%) showed a > 40% improvement in SDAI score, while 1⁄7 cats in placebo group (14.3%) showed a > 40% improvement in SDAI score. This difference was statistically-significant.
Individual variability in the absorption of orally-administered cyclosporine was high. Trough whole-blood cyclosporine levels ranged from 32.1 ng/ml to 1,576.2 ng/ml. At the end of the 6 week observation period, there was a statistically-significant difference among cats with trough whole-blood cyclosporine levels > 300 ng/ml (72.3% improvement) compared with cats with cyclosporine levels < 300 ng/ml (28.2% improvement).
Whole-blood cyclosporine levels > 300 ng/ml were associated with significant improvement in oral inflammation in cats with chronic stomatitis that had previously undergone premolar-molar or full-mouth extraction.