Silk Road forums

Discussion => Drug safety => Topic started by: Samsung100 on May 21, 2012, 08:46 am

Title: 25i-nbome cross tolerance?
Post by: Samsung100 on May 21, 2012, 08:46 am
So a couple of weeks ago I had some time off work and really wanted to try some of this nbome. I took 2.5 tabs of DudeRugs' tabs, held between top lip and gum for half an hour, and didn't get any visuals just felt a bit different. Was wondering if this is because I had a few E's the night before? I would usually wait a week before doing it but I only had a couple of nights off. Want to try it again tonight as I have been sober a full 2 weeks.
Title: Re: 25i-nbome cross tolerance?
Post by: BoNgOn on May 21, 2012, 12:51 pm
Were you drinking? I find anything in the mouth destroys 25i, brush your teeth before dosing next time.
Title: Re: 25i-nbome cross tolerance?
Post by: candorean on May 21, 2012, 02:22 pm
MDMA absolutely has crosstolerance with 25i. I've looked it up before and found this study: http://www.ncbi.nlm.nih.gov/pubmed/1357158 . The test used 5-htp system agonists (which are the same way hallucinogens work) and found significant cross tolerance. Not a big surprise because MDMA's mechanism of action starts at 5-htp. I just realized I sound like a huge geek lol. Have fun tonight, two weeks definitely should have helped
Title: Re: 25i-nbome cross tolerance?
Post by: Samsung100 on May 21, 2012, 07:26 pm
Nah I'm not a drinker so that wouldn't be it, so must have been because of the MDMA. Thanks candorean I was looking for something like that.