Silk Road forums

Discussion => Drug safety => Topic started by: Orinoko Flow on December 17, 2012, 08:08 pm

Title: 5 htp ??
Post by: Orinoko Flow on December 17, 2012, 08:08 pm
Anyone got any recommendations on dosing? 
Title: Re: 5 htp ??
Post by: Orinoko Flow on December 18, 2012, 01:41 pm
Any takers? ;D
Title: Re: 5 htp ??
Post by: jerryskid on December 18, 2012, 02:01 pm
the day after you roll, when you wake up from catching a few hours of sleep, take one a day. When your dreams start becoming vivid, or like me you normally don't dream and you start dreaming, then you can discontinue use until next time. Your serotonin is topped off  :)  It makes a world of difference for me, especially if i break my rule and roll 2 nights in a row. Don't get down or the blahs. Everything i have read says DO NOT take 5htp prior to or the day you roll, it is thought this could damage your serotonin  system, VERY BAD mmkayyy?   Be safe, space your rolls out every month or two
Title: Re: 5 htp ??
Post by: Orinoko Flow on December 18, 2012, 08:35 pm
+1  ;D
Title: Re: 5 htp ??
Post by: happyroller1234 on December 19, 2012, 01:13 am
the day after you roll, when you wake up from catching a few hours of sleep, take one a day. When your dreams start becoming vivid, or like me you normally don't dream and you start dreaming, then you can discontinue use until next time. Your serotonin is topped off  :)  It makes a world of difference for me, especially if i break my rule and roll 2 nights in a row. Don't get down or the blahs. Everything i have read says DO NOT take 5htp prior to or the day you roll, it is thought this could damage your serotonin  system, VERY BAD mmkayyy?   Be safe, space your rolls out every month or two
It's actually a common misconception that some people don't dream.  Everyone dreams.  Every single night.  Some people are just better at retaining the content of these dreams than others.
Title: Re: 5 htp ??
Post by: Ben on December 19, 2012, 03:07 am
As long as you sleep the normal amount of time, you wll dream - regardless if you recall the dreams or not.

5-htp can have some effects comparable;e  to ssri's, in some people it some state of mind.  It is by no means comparable to taking ssri's though.

The most important thing is not to combine them though. Taking 5-htp and ssri's could result into a very serious medical condition mostly known as serotonin syndrome. Worst case the outcome of that is fatal, though i rarely is when proper medical care is at hand.
Title: Re: 5 htp ??
Post by: Howabsurd91 on December 19, 2012, 12:25 pm
I'm going to second Ben's advice about not taking 5htp while simultaneously on an ssri. I was on about 75 mg of Zoloft for severe depression and anxiety. I was so desperate to feel better (and dumb) that I tried to add a low dose of 5htp (50mg) and experienced very worrisome physical and psychological effects about 3 days in and a massive anxiety attack. I will never do that again.

But on it's own, it's fine and works pretty well. I would take 50- 100 mg for a mood lift and relaxation. Also, as said before taking it for a few days after a roll may help alleviate your post-roll blues.

And you will begin to get some crazy dreams, so watch out for that :)
Title: Re: 5 htp ??
Post by: mrlichy on December 19, 2012, 01:20 pm
Anyone got any recommendations on dosing?

From what little Google knows about this issue it's not so much about dosage but the belief on the substance itself ie. there is no evidence that it actually works, so as long as you believe it works, it probably will.

See, e.g., a meta-analysis (http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD003198/full) of 5-HTP related studies which reveals that out of hundreds of tests only two actually qualify as rigorous enough to be taken as serious science.
Title: Re: 5 htp ??
Post by: ThePsych on December 19, 2012, 04:02 pm
I'd highly recommend checking out /r/drugs on reddit. They had a tonne of informative and useful information and a lot to do with 5-HTP and general safety procedures for during/after rolling.
Title: Re: 5 htp ??
Post by: theupsman1 on December 19, 2012, 07:33 pm
I absolutely swear by 5-htp to ease a comedown. I dont know if its helped me pre loading, hard to judge how your roll would of been without it. But after a roll 100mg with a meal and 100mg before bed for a few days absolutely kills any depression the following week. I exercise 5 days a week which probably helps me more than the 5htp but the 5htp deffo gives me that extra perk i need the few days after.
Title: Re: 5 htp ??
Post by: A Riotous Defect on December 20, 2012, 12:23 am
Yeah, pretty much what everyone has said is true.

ABSOLUTELY listen to people when they tell you to not do 5-HTP when you're rolling, to extend a roll, or immediately before your roll. You're already going to have enough serotonin in the synapse and the 5-HTP is only going to do you harm. I've heard anecdotal evidence that it can extend your roll a bit, but if you want to do that you might as well buy some 2c-b. That does wonders for extending a roll, and really adds to the experience, AND it smooths the comedown by a lot if you are one of those people cursed to have bad comedowns.

Some people recommend waiting a month between rolls, but if you maintain a regular regiment of 5-HTP up until a day or two before you roll and the week or so after you roll, you can probably get away with doing it every 2 - 3 weeks. And that's on the safe side. I've known people to do it more than that with no problems, but everyone's body chemistry is different and you really have to feel out the situation before you can make any decisions like that.
Title: Re: 5 htp ??
Post by: valakki on December 20, 2012, 12:49 am
everyone should take a month off and stop using everything once a year.
and that is when you should take 5htp. daily.
thats how i use it. freaking fantastic thing. fixes up the receptors i fucked up....
anyone knows anything about dopamine precursors? i know they are out there...
Title: Re: 5 htp ??
Post by: A Riotous Defect on December 20, 2012, 12:51 am
everyone should take a month off and stop using everything once a year.
and that is when you should take 5htp. daily.
thats how i use it. freaking fantastic thing. fixes up the receptors i fucked up....
anyone knows anything about dopamine precursors? i know they are out there...

Are you talking about basically the equivalent of 5-HTP except for dopamine?
Title: Re: 5 htp ??
Post by: valakki on December 20, 2012, 12:53 am
yep
Title: Re: 5 htp ??
Post by: A Riotous Defect on December 20, 2012, 12:57 am
yep

That's L-Dopa, a prescription drug for parkinson's patients. It's dopamine that can enter the blood-brain barrier, since ingesting pure dopamine does nothing.

However, it's not something you can get from the supermarket or anything. Not that you would need to - unless you're a serious tweaker, your dopamine replenishes a whole lot better than serotonin does. Yer dopamine receptors are altogether more hardy than your serotonin receptors. You shouldn't have to worry about replenishing your dopamine with the aid of medicine.
Title: Re: 5 htp ??
Post by: valakki on December 20, 2012, 01:07 am
yep

That's L-Dopa, a prescription drug for parkinson's patients. It's dopamine that can enter the blood-brain barrier, since ingesting pure dopamine does nothing.

However, it's not something you can get from the supermarket or anything. Not that you would need to - unless you're a serious tweaker, your dopamine replenishes a whole lot better than serotonin does. Yer dopamine receptors are altogether more hardy than your serotonin receptors. You shouldn't have to worry about replenishing your dopamine with the aid of medicine.

Thanks for the info. i will look into this. thumbs up.
Title: Re: 5 htp ??
Post by: Orinoko Flow on December 20, 2012, 11:33 pm
It helps pre loading if you use it a lot.

I rolled 5-10 times a month for 1.5 years and did serveral experiments. It can be hit or miss and sometimes it has to do with the quality of the rolls.

You rolled how i roll fuck :o
Title: Re: 5 htp ??
Post by: Ben on December 21, 2012, 01:37 am
L-Dopa seems to be fairly useless as a recreational drug. Its mechanism of action on the dopamine system is comparable to that of 5-htp on the serotonin system, but people don't usually lack dopamine at all, unless this is caused by disease.

Adding extra dopamine to the brain of a healthy person doesn't do much since it doesn't increase the amount released by the neurons. Similarly, 5-htp doesn't have hat noticable an effect on most people unless they are for some reason short on serotonin.

As for drug combination problems: Just do not take 5-htp in combination with ssri's or mdma, it will add nothing to the experience of the latter, but can pose a very serious health risk with both. Serotonin syndrom can be deadly, and also cause you to be unconcious, hindering diagnosis that could suggest a proper cause of action for medical workers.
Title: Re: 5 htp ??
Post by: A Riotous Defect on December 21, 2012, 03:48 am
L-Dopa seems to be fairly useless as a recreational drug. Its mechanism of action on the dopamine system is comparable to that of 5-htp on the serotonin system, but people don't usually lack dopamine at all, unless this is caused by disease.

Adding extra dopamine to the brain of a healthy person doesn't do much since it doesn't increase the amount released by the neurons. Similarly, 5-htp doesn't have hat noticable an effect on most people unless they are for some reason short on serotonin.

As for drug combination problems: Just do not take 5-htp in combination with ssri's or mdma, it will add nothing to the experience of the latter, but can pose a very serious health risk with both. Serotonin syndrom can be deadly, and also cause you to be unconcious, hindering diagnosis that could suggest a proper cause of action for medical workers.

Very good information! And yes, most parkinsonian drugs like L-Dopa and Requip seem to do very little recreationally. I'm prescribed requip for my moderate restless leg syndrome, and have found that it has an extremely low abuse potential despite activating a fuckton of different receptors of all sorts in the brain. I think as far as dopamine goes it's a D1 and D6 receptor agonist, but I could be mistaken... I just remember those for some reason.
Title: Re: 5 htp ??
Post by: knexx on December 21, 2012, 06:58 am
My post roll 5-HTP regimen is 150mg per day for 2-3 days, then down to 100mg per day til the end of the week, then 50 per day for just a couple more days.

Eat turkey! Turkey is full of tryptophan. Same with chicken! Great for balancing out your neurotransmitters.

Someone said earlier to take 5HTP until you have vivid dreams...and that is interesting but the vivid dreams are more likely due to the fact that many 5-HTP supplements also combine Vitamin B6 (Aspartate) which is well known for causing vivid dreams that are more easily remembered.

I seem to recall that there used to be a message board of people who would take really high doses of B6 right before bed (like 50mg!) and then they would share their dreams with others.
Title: Re: 5 htp ??
Post by: A Riotous Defect on December 21, 2012, 12:49 pm
I seem to recall that there used to be a message board of people who would take really high doses of B6 right before bed (like 50mg!) and then they would share their dreams with others.

This sounds interesting! Never heard of it before. I love vivid dreams, but I had no chance inducing them by will so far.

Which vendor deals B6?  8)

Hulk

You can get that shit from the grocery store, man. xD

( I hope that wasn't a joke and I'm just missing out on the sarcasm :P )
Title: Re: 5 htp ??
Post by: knexx on December 22, 2012, 12:13 am
B6 is pretty common in lots of things... from your multivitamin to energy drinks... fairly abundant in food.

But if you are interested in the dream thing, then I highly recommend a sport supplement: ZMA, appropriately named because it contains Zinc, Magnesium, and Aspartate (B6). I get the deepest sleep and some of the craziest dreams on that. Many people are deficient in magnesium and zinc so it's beneficial for more than just the B6 :P
Title: Re: 5 htp ??
Post by: A Riotous Defect on December 22, 2012, 01:12 am
B6 is pretty common in lots of things... from your multivitamin to energy drinks... fairly abundant in food.

But if you are interested in the dream thing, then I highly recommend a sport supplement: ZMA, appropriately named because it contains Zinc, Magnesium, and Aspartate (B6). I get the deepest sleep and some of the craziest dreams on that. Many people are deficient in magnesium and zinc so it's beneficial for more than just the B6 :P

Yes, and magnesium is also VERY VERY VERY good if you're doing any sort of drug with any stimulant activity at all because it eliminates almost completely the bruxism associated with it. You'd be surprised how jacked you can make your teeth when you're clenching them all the time.
Title: Re: 5 htp ??
Post by: Ben on December 22, 2012, 02:05 am
It might be one of those myths though. There is a similar one about vitamin B1 protecting you from mosquito bites - a fair number of people believe it does, while that effect has not been demonstrated in any tests.

Supplements like zinc or magnesium aren't likely to cause any noticeable effect either, unless you are suffering from a deficiency.

Things that are supposed to cause you to remember dreams and such can be effective as long as you believe in them though. Excluding placebo effect in these cases can only be done with double blind trials. Otherwise, just the notion that you will remember more dreams may actually make that come true, which is also perfectly valid for techniques that do no require any substances like simply repeating "i will remember by dreams tonight" before falling asleep.
Title: Re: 5 htp ??
Post by: A Riotous Defect on December 22, 2012, 02:58 am
It might be one of those myths though. There is a similar one about vitamin B1 protecting you from mosquito bites - a fair number of people believe it does, while that effect has not been demonstrated in any tests.

Supplements like zinc or magnesium aren't likely to cause any noticeable effect either, unless you are suffering from a deficiency.

Things that are supposed to cause you to remember dreams and such can be effective as long as you believe in them though. Excluding placebo effect in these cases can only be done with double blind trials. Otherwise, just the notion that you will remember more dreams may actually make that come true, which is also perfectly valid for techniques that do no require any substances like simply repeating "i will remember by dreams tonight" before falling asleep.

You might be right about the magnesium as far as dreams go, but it most definitely helps with bruxism. It's saved me many a night spent rolling tits.
Title: Re: 5 htp ??
Post by: Aurelius Venport on December 22, 2012, 07:59 am
I cut my molly with mag and b6 for the idiots to dumb to do harm reduction themselves.

it nearly saved my life when I OD'd and brought me out of scary ass paraylsis!!!

Its great for clenching too!
Title: Re: 5 htp ??
Post by: BenCousins on December 22, 2012, 10:15 am
everyone should take a month off and stop using everything once a year.
and that is when you should take 5htp. daily.
thats how i use it. freaking fantastic thing. fixes up the receptors i fucked up....
anyone knows anything about dopamine precursors? i know they are out there...

Tyrosine is the dopamine precursor before L-Dopa it can be brought off ebay