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Discussion => Drug safety => Topic started by: poolsclosed on July 16, 2012, 08:02 pm

Title: Topical application of drugs - Possible? Feasible? Potentially awesome?
Post by: poolsclosed on July 16, 2012, 08:02 pm
Hey forums, I've got a pharmacological question for those who might know: I'm looking to make topical gels/creams of different drugs, particularly MXE HCl but perhaps others. I have a lot of motivations for this, primarily for topical pain relief but also for potential interesting effects, especially when applied to certain parts of the body. An oral gel would also be interesting.

There are a three main obstacles to the realization of this idea, primarily:
- How to create a gel or cream that is safe to use and cost effective
- How to add substances to the gel or cream, or in other words, how to ensure solubility
- How to make sure the substances can be absorbed through the skin (and identifying whether or not the ROA would be wasteful or not)

There's also the question of whether topical application is even necessary at all. I have friends who suffer from aches and pains and I think such a product would be useful for them. I've found MXE to be a great pain reliever and its anesthetic effects last for quite a while, so I think it might be beneficial. Might there be other substances which would be effective in this form as well?

I found a neutral, non-active topical solution online at www.primordialperformance.com but I'm not sure if it will allow MXE HCl to dissolve. My knowledge of chemistry is pretty basic. I do know that dissolving MXE in distilled water is pretty easy if the water is heated slightly (lukewarm at least).

If the idea is no good, that's fine. I'm just performing a bit of a thought experiment right now :)

Of course, thank you in advance for your input.
Title: Re: Topical application of drugs - Possible? Feasible? Potentially awesome?
Post by: smokeweed420 on July 16, 2012, 09:34 pm
Very interesting idea. LSD is the only drug i can think of the works for sure. i would think that some type of chemical would be necessary to help absorption into the skin. let us know how the results turn out! I tried some MXE from TheEmporium from the UK and it was completely awesome. i had so much fun! but recently i tried some from a US vendor called Awakened and it made me feel horrible. Paranoia, no Euphoria. i have no idea whats up with it. im still trying to figure it out.
Title: Re: Topical application of drugs - Possible? Feasible? Potentially awesome?
Post by: poolsclosed on July 16, 2012, 11:23 pm
Very interesting idea. LSD is the only drug i can think of the works for sure. i would think that some type of chemical would be necessary to help absorption into the skin. let us know how the results turn out! I tried some MXE from TheEmporium from the UK and it was completely awesome. i had so much fun! but recently i tried some from a US vendor called Awakened and it made me feel horrible. Paranoia, no Euphoria. i have no idea whats up with it. im still trying to figure it out.
MXE has widely varying subjective effects, not only between batches, but between doses. However, I like Awakened's MXE. To each his own :) thanks for the well-wishing.
Title: Re: Topical application of drugs - Possible? Feasible? Potentially awesome?
Post by: phoz4us on July 20, 2012, 08:19 pm
DMSO- but do it under sterile conditions and you had better trust the purity of what you're using, because it'll all absorb along with it. Also some materials may not be soluble in DMSO.
Title: Re: Topical application of drugs - Possible? Feasible? Potentially awesome?
Post by: poolsclosed on July 21, 2012, 02:59 am
DMSO- but do it under sterile conditions and you had better trust the purity of what you're using, because it'll all absorb along with it. Also some materials may not be soluble in DMSO.
I'd never heard of that, I'll bookmark it and look into it. Sounds promising if it won't cause nasty reactions when combined with XYZ chemical... I'll be sure to be safe, sterile, and sure!
Title: Re: Topical application of drugs - Possible? Feasible? Potentially awesome?
Post by: Gary Oak on July 21, 2012, 04:01 am
I think topical MXE would be incredible! There would be so many possibilities opened up if this were to happen! :D It could help so many people, but I have no clue regarding the feasibility of it.
Title: Re: Topical application of drugs - Possible? Feasible? Potentially awesome?
Post by: febbraio2468 on July 21, 2012, 04:04 am
DMSO- but do it under sterile conditions and you had better trust the purity of what you're using, because it'll all absorb along with it. Also some materials may not be soluble in DMSO.

Yea, try DMSO. Way back when people were trying it to use DMSO  and heroin or something to absorb the drug through their skin.
 
Title: Re: Topical application of drugs - Possible? Feasible? Potentially awesome?
Post by: phoz4us on July 21, 2012, 04:41 pm
DMSO- but do it under sterile conditions and you had better trust the purity of what you're using, because it'll all absorb along with it. Also some materials may not be soluble in DMSO.
I'd never heard of that, I'll bookmark it and look into it. Sounds promising if it won't cause nasty reactions when combined with XYZ chemical... I'll be sure to be safe, sterile, and sure!
That reminded me of a story i had heard from one of my teachers , Im not sure how true it is but, it fits the subject:
A few years ago there were a string of incidents in which corpses, while in the hospital morgue , hours after death would release an unknown noxious gas in large enough volumes that many floors of the hospital would have to be evacuated. THe gas was not only putrid to the smell but was capable of causing temporary paralysis.
THe cause was that those people were using cocaine with DMSO on a semi regular basis before they died. ( using cocaine with DMSO didnt cause the deaths, to make clear )
Title: Re: Topical application of drugs - Possible? Feasible? Potentially awesome?
Post by: poolsclosed on July 21, 2012, 05:08 pm
DMSO- but do it under sterile conditions and you had better trust the purity of what you're using, because it'll all absorb along with it. Also some materials may not be soluble in DMSO.
I'd never heard of that, I'll bookmark it and look into it. Sounds promising if it won't cause nasty reactions when combined with XYZ chemical... I'll be sure to be safe, sterile, and sure!
That reminded me of a story i had heard from one of my teachers , Im not sure how true it is but, it fits the subject:
A few years ago there were a string of incidents in which corpses, while in the hospital morgue , hours after death would release an unknown noxious gas in large enough volumes that many floors of the hospital would have to be evacuated. THe gas was not only putrid to the smell but was capable of causing temporary paralysis.
THe cause was that those people were using cocaine with DMSO on a semi regular basis before they died. ( using cocaine with DMSO didnt cause the deaths, to make clear )
Haha interesting story. I searched "cocaine dmso" and didn't find anything but that would be an example of something that hypothetically could go wrong... well I'll have to tread carefully and see if I can develop a product that works. If it does, I'll be sure to share the recipe. In the meantime more advice is definitely welcome.
Title: Re: Topical application of drugs - Possible? Feasible? Potentially awesome?
Post by: gambino on July 22, 2012, 12:37 am
I have read that DMSO, when used for transdermal drug administration, imparts a not-so-pleasant garlicky taste/smell in the mouth.  So it's a real vibe killer when you break out the DMSO at parties.