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Discussion => Drug safety => Topic started by: ianfleming on October 22, 2012, 03:38 am

Title: MDMA and LSD cross tollerances
Post by: ianfleming on October 22, 2012, 03:38 am
I have a friend who is supposed to trip on LSD with me (first timers) on the 3rd.
She's planning on taking MDMA October 24th (first time as well).

I know that MDMA is not a typical psychedelic, but it also has a 1 month tolerance period.
We're trying to be clean for 2 weeks prior to our LSD experience.

In short, will the MDMA use roughly 11 days prior to LSD have any effect on the potency of the LSD?
Title: Re: MDMA and LSD cross tollerances
Post by: ianfleming on October 22, 2012, 12:48 pm
Please answer, this is a fairly important question.
Title: Re: MDMA and LSD cross tollerances
Post by: ianfleming on October 22, 2012, 07:33 pm
Ok, I dont have time for this.
Positive karma for anyone who post a worthwhile response
Title: Re: MDMA and LSD cross tollerances
Post by: microRNA on October 22, 2012, 07:45 pm
i dont know for 100 percent sure, for every individual things are different

but no, i dont believe using mdma once a week and a half before the lsd should produce a significant reduction in the experience.

i know during festivals people take mdma one night, then the very next day they are still able to trip with normal doses

technically the flood of serotonin from mdma could down regulate the receptor lsd acts mainly on - but only using once shouldnt produce much down-regulation, and even so after a week the tolerance would be back pretty close to normal. since lsd is in a way over stimulating the 5ht2a receptor, one should still be susceptible to the neural changes that occur even if the receptor levels are slightly lower

generally psychedelic cross-tolerance is assumed to be around 3 days to one week, so waiting 10 days should be perfectly fine
Title: Re: MDMA and LSD cross tollerances
Post by: microRNA on October 25, 2012, 11:09 am
youre welcome...

took the time to do the research you should have to help you when i was busy even though you were getting impatient and frustrated and i dont even get a thank you
Title: Re: MDMA and LSD cross tollerances
Post by: ianfleming on October 25, 2012, 11:15 am
I gave you thank as in the karma thingy. But I've also had a lot to do recently.
Thank you anyway, though you more or less just reconfirmed my own theory.

BTW, she decided not to since it might interfere with her period and because of the LSD trip coming up.
Still, thanks anyway.
Title: Re: MDMA and LSD cross tollerances
Post by: microRNA on October 25, 2012, 11:41 am
sorry i was just bored and being kinda joking since you were so pushy for an answer

i re-read my post and it probably came off much more rude than i intended, sorry

i left a post in that + karma thread and couldnt tell actually

thanks for your civil response anyway though :)
Title: Re: MDMA and LSD cross tollerances
Post by: ianfleming on November 07, 2012, 05:03 am
Ok, so this friend and I tripped on some NICE 'cid this past weekend, VERY BEAUTIFUL.

She is now planning on eating a blue defqon bean this weekend. This will be her first time with MDMA, do you guys think she will be able to have a truly full first time with the molly if shes tripped so soon beforehand?

We're also planning on eating another 2 blotters each the following weekend after that, though I assume that should be fine, as I've been reading about people tripping after a roll, with no issues.
Title: Re: MDMA and LSD cross tollerances
Post by: Purple_Hue000 on November 08, 2012, 12:13 am
I'm pretty sure there isn't much of a cross tolerance between the two. Maybe something slight. But You'll be good.
Title: Re: MDMA and LSD cross tollerances
Post by: Stormtrooper420 on November 08, 2012, 03:44 am
Well you gotta put into mind that LSD mimics seratonin to your 5ht receptors, I am tripping balls right now so I don't know if this would make a huge difference but I thought I'd share my input :D

Best Regards,
Stormtrooper
Title: Re: MDMA and LSD cross tollerances
Post by: ianfleming on November 10, 2012, 05:27 am
I'm going ot assume that if people say you have to wait until 2 weeks to trip well on lsd again, then I'll assume this means you are not baseline until then.