Silk Road forums

Discussion => Drug safety => Topic started by: J4M136 on February 09, 2012, 08:48 pm

Title: Amitriptyline & MDMA - Safe??? Chemistry Question Maybe?
Post by: J4M136 on February 09, 2012, 08:48 pm
Hi, I have a friend who this evening has taken a small amount of Amitriptyline to sleep well before tomorrow night. Tomorrow night she is supposed to be joining us for some of Ivorys MDMA. What I would like to know is

1. Is this a safe combination? I read on wiki the halflife of Amitriptyline can be up to 50 hours so will still be in her system

2. Is this one of the anti-depressants I have heard can pretty much cancel a roll from happening?

Anyone have any experiences of these when taken together? She had already taken it before I was told or would of advised against it. I did do a quick search the only mention I could find was in the OVDB discussion subforum [http://dkn255hz262ypmii.onion/index.php?topic=7836.0] as one of the recommended substances neuroprotective against MDMA-induced neurotoxicity Under Tricyclic Antidepressants (TCAs):Amitriptyline (Elavil)

If there will be any effect what would it be?

Can anyone shed any light on this for me?

A couple of things that may help people answering. This is a once only dose to help her sleep, not a prescribed medicine. No history of depression. And she has taken MDMA numerous times so is not her first roll.

Thanks in advance.
Title: Re: Amitriptyline & MDMA - Safe??? Chemistry Question Maybe?
Post by: 328502E on February 09, 2012, 09:49 pm
1 - Yes, this would be safe.  It isn't ideal, but as long as she isn't taking 500mg of MDMA she should be fine.

2 - Yes, this is the kind of antidepressent that can cancel a roll.  You said she took a small amount, so likely there won't be much of an issue.  If she takes it daily or in normal quantities, she probably won't roll as hard.