Silk Road forums

Discussion => Off topic => Topic started by: flicky42 on August 30, 2012, 02:29 am

Title: 25i dosage
Post by: flicky42 on August 30, 2012, 02:29 am
I bought some 25I on a clearnet site and the tabs are 1 mg per tab. I took one and had a very weak trip, body high but almost no visuals. Should I take 2? Also it was in a hot place for a night does it degrade with heat because that heat would of degraded LSD.


Thank you anyone who comments
Title: Re: 25i dosage
Post by: TheAbsurd on August 30, 2012, 02:33 am
Did you place it on your upper gums? I've tripped balls off 1mg, so the blotter probably didn't have 1mg on it. A member here said they left their blotters in 100 degree weather and they didn't degrade.
Title: Re: 25i dosage
Post by: flicky42 on August 30, 2012, 02:34 am
I put it under my tounge like with acid. Is that bad place? I'll try the upper gums next time.

Title: Re: 25i dosage
Post by: TheAbsurd on August 30, 2012, 02:37 am
Yeah you fucked up. I did my first time too.  ;D

Take 1 blotter and put it on your upper gums for 30 minutes. NBOMe doesn't like saliva, so you get very minor effects from putting it on your tongue. Also, eating it is 100% worthless so there's no need to swallow paper for no reason.
Title: Re: 25i dosage
Post by: BlarghRawr on August 30, 2012, 02:43 am
If it's still weak after putting it on your upper gums, then it's just plain shit. Just a warning.

Or so I've heard. I don't have 25i experience.
Title: Re: 25i dosage
Post by: flicky42 on August 30, 2012, 02:45 am
Wait can you guys elaborate on this. MXE can sit in your mouth with saliva (i think) and LSD can too (i think).

I don't think you're wrong I'm just very interested in the reasoning.
Title: Re: 25i dosage
Post by: BlarghRawr on August 30, 2012, 02:51 am
Wait can you guys elaborate on this. MXE can sit in your mouth with saliva (i think) and LSD can too (i think).

I don't think you're wrong I'm just very interested in the reasoning.
MXE and LSD are chemically different from 25i. That alone should be reasoning enough.

But as far as I understand it, the reason 25i is worthless when swallowed is because the first-pass metabolism wipes the -nBOME from it, leaving you with just 2c-i or something to that effect. Probably some enzymes in the saliva that do much the same, really.
Title: Re: 25i dosage
Post by: flicky42 on August 30, 2012, 03:35 am
Wait can you guys elaborate on this. MXE can sit in your mouth with saliva (i think) and LSD can too (i think).

I don't think you're wrong I'm just very interested in the reasoning.
MXE and LSD are chemically different from 25i. That alone should be reasoning enough.

But as far as I understand it, the reason 25i is worthless when swallowed is because the first-pass metabolism wipes the -nBOME from it, leaving you with just 2c-i or something to that effect. Probably some enzymes in the saliva that do much the same, really.

MXE and LSD are chemically different from each other as well but they still work the same way sublingually. It just seems odd that taking a drug bucally is that much more effective then under the tounge to me. I don't think MAOI's are in saliva but I could be wrong.
Title: Re: 25i dosage
Post by: flicky42 on August 30, 2012, 03:42 am
O i think I am wrong. MAO enzymes are present in saliva so I guess 25i is way more sensitive to degradation by mao than LSD.

I just seems strange to me becuase the 2c series isn't at all. I guess when you branch the nitrogen more it is more prone to cleavage? Ah I wish I remembered more of my chemistry from college.
Title: Re: 25i dosage
Post by: BlarghRawr on August 30, 2012, 03:48 am
O i think I am wrong. MAO enzymes are present in saliva so I guess 25i is way more sensitive to degradation by mao than LSD.

I just seems strange to me becuase the 2c series isn't at all. I guess when you branch the nitrogen more it is more prone to cleavage? Ah I wish I remembered more of my chemistry from college.
I believe it has to do with the whole 2c-i vs 25i-nBOMe difference. 25i-nBOMe is, as I understand it, basically a chemical-addition to what is already 2c-i. So the whatever enzyme reverses that process, leaving you with just 2c-i that gets into your system.