Silk Road forums

Discussion => Drug safety => Topic started by: Niriane on December 07, 2012, 02:35 am

Title: Cross tolerance between LSD / Mephedrone?
Post by: Niriane on December 07, 2012, 02:35 am
Is there? If there is, how long should the window be?
Title: Re: Cross tolerance between LSD / Mephedrone?
Post by: mnak on December 07, 2012, 02:54 am
mephedrone mostly effects dopamine.

LSD mostly effect serotonin.

mostly.  mephedrone does have some effects similar to MDMA which indicates it does something with serotonin.

My speculation is that cross tolerance is very minimal.
Title: Re: Cross tolerance between LSD / Mephedrone?
Post by: Niriane on December 08, 2012, 12:41 am
Can anyone else add in their thoughts?
Title: Re: Cross tolerance between LSD / Mephedrone?
Post by: Ballzinator on December 08, 2012, 01:11 am
Quote from: Wikipedia
The cathinone derivatives methcathinone and methylone act in a similar way to amphetamines, mainly acting on catecholamine transporters, so mephedrone is expected also to act in this way. The actions of amphetamines and cathinones are determined by the differences in how they bind to noradrenalin, dopamine and serotonin transporters.
No one really knows. It is very possible that mephedrone causes the serotonin transporter to reverse its direction of flow, which could result in some cross-tolerance with serotonergic psychedelics. This effect would be marginal though IMO.
Title: Re: Cross tolerance between LSD / Mephedrone?
Post by: Niriane on December 15, 2012, 07:14 am
Someone else? Haha. It's just that my boyfriend wants to do meph and then drop acid the day after.