Silk Road forums

Discussion => Drug safety => Topic started by: Pax on February 05, 2013, 11:01 am

Title: How long will these chemicals go without being researched?
Post by: Pax on February 05, 2013, 11:01 am
or How long do  chemicals typically go without being researched.
   (4-AcO-DET) -  4-Acetoxy-DET (4-Acetoxy-N,N-diethyltryptamine), also known as ethacetin, ethylacybin or 4-AcO-DET is a psychedelic tryptamine. It was first synthesized in 1958 by Albert Hofmann in the Sandoz lab.[1]
It is expected that the compound is quickly hydrolyzed into the free phenolic 4-HO-DET by serum esterases, but human studies concerning the metabolic fate of this drug are lacking.
          a little more info but still considered a research chemical also no health profile  (4-AcO-DMT)- O-Acetylpsilocin (psilacetin) and several other esters of psilocin were patented on January 16, 1963 by Sandoz Ltd. via Albert Hofmann & Franz Troxler (US Patent # 3,075,992).[1] Despite this fact, psilacetin remains a psychedelic with a limited history of use. It is theorized to be a prodrug for psilocin, as is psilocybin, which is naturally occurring in various mushrooms. Psilacetin is O-acetylated psilocin, whereas psilocybin is O-phosphorylated.
                   (4-AcO-MiPT), or 4-acetoxy-N-methyl-N-isopropyltryptamine is a hallucinogenic tryptamine. It is closely related to O-acetylpsilocin and MiPT.
There is very little information on the human pharmacology or toxicity of 4-AcO-MiPT.
                    for fuck sake must I go on the whole (2C family),(Nbome family),(DOx),(DOI),The whole (TMA family)
there us very little if ANY health profile on an of these drugs some of them for 50 years.That really scares me away from trying some of these drugs cause I might not know what the have done to me within my lifetime any help?
Title: Re: How long will these chemicals go without being researched?
Post by: valakki on February 05, 2013, 12:52 pm
till some big pharma company decides to sell it as medication. otherwise there is no reason to test these.

but you can do something if you want to. just buy a lot of rats and start giving them measured out doses.  you can find  the ld50 this way and side effects like hairloss, blindness and obvious things like that...
Title: Re: How long will these chemicals go without being researched?
Post by: Twelve_Pickles on February 05, 2013, 01:05 pm
till some big pharma company decides to sell it as medication. otherwise there is no reason to test these.

but you can do something if you want to. just buy a lot of rats and start giving them measured out doses.  you can find  the ld50 this way and side effects like hairloss, blindness and obvious things like that...

or unless there is a huge public outbreak of people taking these drugs and OD'ing, negative media and public attention can help force researchs' hand
Title: Re: How long will these chemicals go without being researched?
Post by: TheBusiness on February 05, 2013, 01:08 pm
If it gives you a boner, they'll research the shit out of it... even more than you do.
Title: Re: How long will these chemicals go without being researched?
Post by: Pax on February 05, 2013, 06:59 pm


till some big pharma company decides to sell it as medication. otherwise there is no reason to test these.

but you can do something if you want to. just buy a lot of rats and start giving them measured out doses.  you can find  the ld50 this way and side effects like hairloss, blindness and obvious things like that...

or unless there is a huge public outbreak of people taking these drugs and OD'ing, negative media and public attention can help force researchs' hand
This is what I was afraid of why do we have OD's,deaths and other complications for months even years before it gets coverage are there any non profits or independent scientists researching these chems if so who?
Title: Re: How long will these chemicals go without being researched?
Post by: Twelve_Pickles on February 06, 2013, 12:17 pm


till some big pharma company decides to sell it as medication. otherwise there is no reason to test these.

but you can do something if you want to. just buy a lot of rats and start giving them measured out doses.  you can find  the ld50 this way and side effects like hairloss, blindness and obvious things like that...

or unless there is a huge public outbreak of people taking these drugs and OD'ing, negative media and public attention can help force researchs' hand
This is what I was afraid of why do we have OD's,deaths and other complications for months even years before it gets coverage are there any non profits or independent scientists researching these chems if so who?


the moneys in the wrong hands always gets placed in the wrong pocket.
Title: Re: How long will these chemicals go without being researched?
Post by: Ben on February 07, 2013, 02:48 am
This is just how the system works,  however.

The research and clinical trials to bring a drug to the market are easily in the order of a billion dollars. Doing so can yield about 10 years of patent protected sales, after which others can produce generics and the value of  the medication drops to zero.

When it comes to profiting from patents prior art becomes a problem too. For example it would be impossible to patent caffeine, despite it may be very effective in increasing alertness for drivers. Without that patent protection there simply is no money to be made, not even for clinical trials. This basically is why you can get a cup of  coffee from any gas station, but you'd have a hard time finding a caffeine tablet that is cheaper than a cup of coffee.
Title: Re: How long will these chemicals go without being researched?
Post by: Pax on February 07, 2013, 03:17 am
This is just how the system works,  however.

The research and clinical trials to bring a drug to the market are easily in the order of a billion dollars. Doing so can yield about 10 years of patent protected sales, after which others can produce generics and the value of  the medication drops to zero.

When it comes to profiting from patents prior art becomes a problem too. For example it would be impossible to patent caffeine, despite it may be very effective in increasing alertness for drivers. Without that patent protection there simply is no money to be made, not even for clinical trials. This basically is why you can get a cup of  coffee from any gas station, but you'd have a hard time finding a caffeine tablet that is cheaper than a cup of coffee.
Fuck So ok the governments aren't going to do shit so what can I do. I am no scientist and lack the connections to become one so what can I do to try and push for some research on these chemicals?
Title: Re: How long will these chemicals go without being researched?
Post by: Namarrg0n on February 07, 2013, 09:25 pm
Quote
what can I do to try and push for some research on these chemicals

Get many people together and write to
petitions.whitehouse.gov  ;)
Title: Re: How long will these chemicals go without being researched?
Post by: Ben on February 08, 2013, 02:36 am
You could start your own pharma company and research it further - there is no legal barrier to do so.

There is, however, the matter of financing things. To get a drug from research to market costs at leat a billion in clinical trials and legal proceedings. I presume you do not have that kind of money in the bank, so you would need to source it elsewhere. Nowadays, crowdfunding could  be an option.
Title: Re: How long will these chemicals go without being researched?
Post by: Fallkniven on February 08, 2013, 03:27 am
If it gives you a boner, they'll research the shit out of it... even more than you do.

i had a good LOL at that one

funny! +1 for you dude