Silk Road forums

Discussion => Drug safety => Topic started by: tuna on June 09, 2013, 09:42 am

Title: Mescaline day after 25i nbome
Post by: tuna on June 09, 2013, 09:42 am
25i nbome is famous to cause cross tolerance with other psychedelics due to its activity on 5-HT2A receptor.

Here's data I found on bluelight:
25i agonizes the following receptors [the lower the number, the greater the affinity]
5-HT2A (0.044), 5-HT2C (2), 5-HT6 (73), 5-HT2B (231), u opiate (82), kappa opiate [288]

Mescaline agonizes the following receptors [4.00 = maximum affinity, 0.00 = no affinity]:
Alpha2c (4.00), 5-HT2B (3.97), 5-HT1A (3.61) Imidazoline1 (3.44), 5-HT1E (3.16), alpha 2a (2.92) and very poorly agonizes 5-HT2A & 5-HT2C.

It seems that mescaline agonizes different receptors than 25i.
So, my question: is it enough to assume that would be very little cross tolerance between 25i nbome and mescaline? Or is there something I don't take into account?