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Discussion => Drug safety => Topic started by: Niriane on September 18, 2012, 03:31 am

Title: Does drinking orange juice with MDMA make you roll harder?
Post by: Niriane on September 18, 2012, 03:31 am
Does it really?
Title: Re: Does drinking orange juice with MDMA make you roll harder?
Post by: metaphoe on September 18, 2012, 03:46 am
the acidic juices make the pill break down.. but to much can block absorption

try washin it down with a sprite.. it'll fuk ya brain in half
Title: Re: Does drinking orange juice with MDMA make you roll harder?
Post by: Niriane on September 18, 2012, 03:53 am
the acidic juices make the pill break down.. but to much can block absorption

try washin it down with a sprite.. it'll fuk ya brain in half

"Drink fruit juices.
They are more efficient in replacing lost nutrients. Avoid fizzy drinks as they can cause nausea."

"Avoid 'diet' drinks.
In fact, any drink containing artificial sweeteners (such as aspartame). They contain phenylaline, a substance which increases the neurotoxicity of MDMA."

??
Title: Re: Does drinking orange juice with MDMA make you roll harder?
Post by: Knomo on September 18, 2012, 04:14 am
This is quite a persistent 'myth'. Some people claim it works, while others say it's bullcrap.
There are studies which show that Vitamin C has a positive effect on the serotonin levels in your brain, which makes you roll 'harder'

http://www.erowid.org/chemicals/mdma/images/mdma_article3_chart2.gif

As you can see on that graph (yes it's a study on mice.. so what :P ) mice who have been given MDMA with Vitamin C a week earlier, have twice as high serotonin levels when they roll again a week later. This is compared to mice who have gotten MDMA and a saline solution a week earlier.

Now I don't know the truth, I guess it's somewhere in the middle, but there is also this little thingy called PLACEBO which has an tremendous effect on the brain that should not be forgotten.. :)
Title: Re: Does drinking orange juice with MDMA make you roll harder?
Post by: a_blackbird on September 18, 2012, 05:55 am
orange juice tastes good, but you'll get better effects from preloading with with 5-HTP and a B-complex vitamin for a few days before you start pillin'.  post-loading with the same sort of thing is a good way to get your serotonin back to baseline and stave off suicidal tuesdays.  it takes about 12 hours for 5-HTP to cross the blood-brain barrier, though, so taking a bunch of shit at 8pm and dropping your e at midnight isn't going to do shit except maybe give you an upset stomach.

phenylanine is a chemical precursor to dopamine, if i remember right; extra dopamine will also make you roll harder (and part of the mdma experience is a release of dopamine anyway, not just a massive serotonin dump), but when you're coming down you tend to have an excess supply of dopamine in the brain and very low amounts of serotonin, at which point the dopamine can and will bind to your serotonin receptors and damage them.  a low-dose SSRI (paxil, prozac) is actually a good way to attenuate this during a comedown; the SSRI binds to your serotonin receptors instead and prevents the dopamine from fucking shit up.  yes, that's a technical term.
Title: Re: Does drinking orange juice with MDMA make you roll harder?
Post by: TheBusiness on September 18, 2012, 12:44 pm
As you can see on that graph (yes it's a study on mice.. so what :P ) mice who have been given MDMA with Vitamin C a week earlier, have twice as high serotonin levels when they roll again a week later. This is compared to mice who have gotten MDMA and a saline solution a week earlier.

Now I don't know the truth, I guess it's somewhere in the middle, but there is also this little thingy called PLACEBO which has an tremendous effect on the brain that should not be forgotten.. :)

*Imagines the scientists explaining earnestly to the mice who got the placebo vitamin C pill that they will roll harder... *   

 :D
Title: Re: Does drinking orange juice with MDMA make you roll harder?
Post by: darthvaderstar on September 18, 2012, 02:35 pm
It actually makes you roll harder at a shorter time because vitamin c is suppose to help with your brain after some mdma.
Title: Re: Does drinking orange juice with MDMA make you roll harder?
Post by: Ben on September 19, 2012, 01:21 am
I think this story originates from drinking the juice of grapefruits rather then oranges.

Grapefruits do contain substances that will load the cyp34A metabolic pathway. This causes consuming grapefruit to inhibit the breakdown of a whole array of substances, ranging from illicit drugs to prescribed cholesterol-reducing medications.

Note that this effect is only present in grapefruit though, not in oranges.
Title: Re: Does drinking orange juice with MDMA make you roll harder?
Post by: Shroomeister on September 19, 2012, 01:34 am
I just always assumed this stemmed from the ol' LSD - OJ myth.


Not sure of any science to that one either. I just always thought LSD = Acid. OJ = Acid (citric)

..... I have done both with and with out and cant say it was noticeable either way.
Title: Re: Does drinking orange juice with MDMA make you roll harder?
Post by: TheBusiness on September 19, 2012, 01:37 am
Maybe we are talking about 2 different things then.. I hadn't heard of the grapefruit thing.

Where vitamin C helps is that it is an effective anti-oxidant. MDMA clogs up the receptors so serotonin uptake can't occur. This floods the brain with excess serotonin and the receptors all stay full, which feels great. But some of the serotonin that isn't being used starts to expire causing free radicals and toxicity in the brain. This is what vitamin C clears up, which stops you from doing more damage and makes the come down much more gentle.

If you have any info on the grapefruit thing let us know Ben!
Title: Re: Does drinking orange juice with MDMA make you roll harder?
Post by: Shroomeister on September 19, 2012, 02:07 am
Isn't Grapefruit just vitamin C also?
Title: Re: Does drinking orange juice with MDMA make you roll harder?
Post by: may on September 23, 2012, 06:22 pm
Isn't Grapefruit just vitamin C also?

Some info on (clearweb) bluelight here, under the grapefruit section: http://www.bluelight.ru/vb/threads/79027-MDMA-Essential-Guide-v1-00?postid=912507#post912518
Title: Re: Does drinking orange juice with MDMA make you roll harder?
Post by: blowdrobro on September 23, 2012, 06:34 pm
I tried it a few times; I didn't notice a difference, but other did. I don't know the science just that anecdote.
Title: Re: Does drinking orange juice with MDMA make you roll harder?
Post by: Shroomeister on September 23, 2012, 06:41 pm
Isn't Grapefruit just vitamin C also?

Some info on (clearweb) bluelight here, under the grapefruit section: http://www.bluelight.ru/vb/threads/79027-MDMA-Essential-Guide-v1-00?postid=912507#post912518

Thanks for the link. Gonna read it over.
Title: Re: Does drinking orange juice with MDMA make you roll harder?
Post by: may on September 23, 2012, 07:03 pm
Isn't Grapefruit just vitamin C also?

Some info on (clearweb) bluelight here, under the grapefruit section: http://www.bluelight.ru/vb/threads/79027-MDMA-Essential-Guide-v1-00?postid=912507#post912518

Thanks for the link. Gonna read it over.

No worries, this isn't something I have experience of (using grapefruit juice) so wanted to post a link rather than any second hand opinions etc.
Title: Re: Does drinking orange juice with MDMA make you roll harder?
Post by: Ben on September 24, 2012, 12:56 am
It's not about vitamin C, and grapefruits are not identical to oranges in this respect.

The concept of grapefruit (juice) altering the effect of certain medications is not some folk story, leaflets that come with a number of prescription meds (particularly against cholesterol and such) mention grapefruit specifically as something that should no be consumed when taking the medication.

Illicit drugs also rely on the same pathways however, which explains why combining grapefruit with mdma is not a good idea, but washing them down with orange juice is perfectly fine.