Best method to Convert 1kg P2NP into Amphetamine?

Can anyone shed some light on this please?

I have 1kg P2NP, 50g mercury chloride, magnetic hotplate, 1-3 litre round bottom flasks and lots of chemicals.

Researching the internet just brings up useless 5g reactions!

I do not have a fume hood. Although easy to DIY i don't fancy using one. For some reason huge quantities of hydrogen gas and fans which are not spark proof are a recipe for a explosion i think.


Comments


[8 Points] None:

[deleted]


[5 Points] mymuse100:

Alternative to Al/Hg - the Al/Cu and yes its not 4x greater ammoint at a time XP.. beter catalysts are there

References There has been some talks before about using copper to activate Al:

Now, after lots of experimenting with this method (Lots of time, resources, and at least 40 test reactions ran), a general method has been found that produces approx. the same yields as one would expect from an Al/Hg. So far it's been ran successfully on a various set of nitrostyrenes. (including aromatic nitroalkenes)

Experimental 15g regular Al-foil (folded 4x, in flat strips, 2in long, 0.8in wide) was added into a 2-necked, 2L RBF. The Al-strips were made as flat as possible to avoid them floating to the surface later. 300ml EtOH, 120ml water, 45ml GAA was added in. Lastly 20g of nitrostyrene was added in. A condenser was mounted to the flask, along with a stirring rod attached on the 2nd neck, with a PTFE seal. Contents of the flask were heated to 60C. A solution of 10g CuSO4, 20g NaCl and 40ml hot water was mixed together separately. This was then added all at once to the 2L RBF, and the flask was immediately swirled around to ensure even distribution of the copper solution. Immediately, a vigorous reaction set in. During this, some Al floated to the surface. The stirring rod was lifted up by hand (without moving the PTFE seal) then pushed down on the Al in the flask, in order to keep the Al below the surface as best as possible. After 10 minutes or so, the reaction slowed down, and some Al was still left. Reflux was turned on for 1 hr, under overhead stirring. (If one does not have an overhead stirring motor, simply give the stirring rod an occasional swirl with your hands, to move the flask contents around. If one stirrs enough, then after 1 hrs, most of the Al should be gone.) The reaction was now finished and 300-400ml hot water was added whilst it was still at reflux temperature. It was then quickly re-rigged for distillation, and the alcohol was taken off. The solution was then cooled, ~130g NaOH added under mixing, and it was extracted 3x with DCM (or any solvent of choice). One can also do an in-situ steam distillation, then add acid of choice directly to the distilled water, and evaporate it in the open to be left with the salt. No need to worry about mercury fumes.

Some notes • Generally, this reaction is a bit milder than the Al/Hg. So a larger surface area of Al can be used, and the reaction contents need to be heated a bit before the copper is added, to make it vigorous. • It can be scaled up easily, and the amounts of CuSO4 / NaCl needed do not increase. • It is efficient and environmentally friendly in terms of chemicals used. The alcohol is recycled, the amount of GAA used is small (45ml per 20g styrene), even the water can be recycled. If it's steam distilled, it's not neccessary to add anymore NaOH than what it takes to reach the correct PH, and no solvents would need to be used either. A lot of this possible, because one needs not worry about mercury which would otherwise contaminate everything. • It is believed (although not 100% sure) that most copper will remain as an insoluble solid. • It can probably be used for reductive aminations, but the CuSO4 and NaCl would possibly react with methylamine. Use of CuCl2 in place of CuSO4 and NaCl is possible.

Lastly, it should be noted that the reaction seems very tolerant and consistently produces the same yields, despite large changes in variables. For instance, in the beginning, this reaction was ran with 20g styrene in 250ml water, 250ml GAA, 250ml EtOH in an open beaker, with 50g CuSO4 and 100g NaCl dissolved in. This reaction was a mess, and there was a large amount of green precipitate at the bottom even before it began. Then 5g Al foil at a time, packed together by hand, was held into the reaction with a metal tool. The aluminum was eaten up with vengance, and the solution was boiling hard and solvent actively escaped into the open, and had to be replaced constantly. Nontheless, a total of 40g Al was consumed. And even here, yields were the same (~70%) as with the above reaction.


[4 Points] mymuse100:

Dude . Learn chemistry.... the p2np with murecy chloride is HIGHLY EXOTHERMIC doing batches larger then 5g you will have mercry painted all over you and your walls yes what you need is a sparkless motor a squrill cage fan. Look to the hive to reduce p2np to amph in bulk


[2 Points] mymuse100:

Items: 15L. Plastic Box. Small water pump 5L Beaker. Motor head from a 12V Drill. Variable power supply for the drill. Stirrer rod made with a computer fan. Hot Plate.

Reagents: 25gr -P2NP (Recovered from a "Dungeon Waters Bottle" 12,5gr NaBH4. 250 ml Denatured ethanol bottle. Some water. Some Acetic Acid Some concentrated HCl 100 gr Zinc Dust "activated" 45 gr Ammonium Formate.

The 5L beaker is place in the plastic box with cold water and the small pump recirculating it around the glass. Then a 250 ml Ethanol bottle is open with the mouth and the liquid is place in the beaker with 50-100 ml H2O and 12,5 gr NaBH4 with vigorous stirring. Then the 25 gr of P2NP is added in 3 portions in less than ONE MINUTE. High hydrogen evolution is observed but the flask is big enough. The solution is stirrer for half hour around. At this point, some Acetic acid is used to kill borohydride and made the precipitate a little soluble in the liquid phase. While 100gr of zinc was activated and it was just drain off and added to the nitroalkane mixture. Reaction start a this point for the acid traces on the zinc, and the ammonium formate is drop down in 3 portions in less than one minute. All was stirrer for 15 minutes. Now water bath and stirrer is removed and the beaker is place on the hot plate and 200 ml of concentrated HCl is added in portions. The beaker was heated and stirred with a glass rod for 30-40 minutes. And the reaction was finished at this point. After basification, extraction, boiling out the ammonia, drying the solvent y neutralization... 24 grams of the propylamine sulfate was obtained


[1 Points] mymuse100:

I really suggested other catalysts or covert p2np to p2p then make amp or meth XP


[1 Points] backdoor_nobaby:

HCl+Fe+P2NP-> P2P

Al/Hg+P2P->Am

Alternatively: Al/Hg+EtNO2+P2P->MeAm

Read some patents, it's there.


[1 Points] mymuse100:

Best way in bulk to p2np to p2p . P2p with borohydride