Drugs like W-18 and Carfentanyl are going to be the end of the DNM. They are chemical weapons in a terrorist era. The governement is going to take any and all means to prevent it from entering the country from its only known method: international mail.
If the governement dedicates huge ressources to prevent even the smallest quantity of carfentanyl from entering the country (it has already started in Canada), the mail system, both local and international, is going to be much more heavily scrutinized.
Even if the DNM and TOR remain reliable, what are we going to do if the reliability of the mail system no longer follows up and even domestic packs end up with a 30-40% seizure rate? This might be fat-fetched but I'm pretty sure within 5 years it will be much more difficult to send or receive drugs by mail.
TL;DR; Carfentanyl and similar drugs will haste the completion a mail-scrutiny system that might severly compromise the reliability of DNM trade.
I suggest anyone caught knowingly importing, distributing, or manufacturing carfentanyl should have it shoved down his throats as fair and just punishment.
Tell that to your buddy BenzoChems