Genetic Proof of a fentanyl analog in a vendor's recent batch of #4!!! (ok, just a theory)

I recently used some deductive reasoning based on my own DNA to hypothesize that some unusual #4 gear I got a few weeks ago is likely a fentanyl analog.

Although it's lame and a normal customer has every right to be pissed, I'm not very upset about it which you will see below.. And to be fair, there are no hot spots or anything. If it really isn't H, it's mixed quite well and/or the analog is less potent and much safer than fentanyl..

OK, so I have a heterozygous mutation in my CPY2D6 gene/enzyme (P450 genes) which, if expressed in my body (seems very likely), means a decreased function by the ezyme to break down so many different medicines including certain opitaes..

I've recently been prescribed Wellbutrin (going to kick soon) and in general, my blast offs with I.V. H have been pretty lackluster. The rush and legs are there, but not as intense as pre-Wellbutrin. This is because that gene and enzyme are used in the metabolism of dope (and Wellbutrin fwiw, so not the best med choice but so it's really the only dopamine med in its class) which puts a lot of strain on the enzyme and it can't hang with all of its duties.. The metabolism of dope is actually pretty complex and involves mutliple enzymes, has primary and secondary stages, etc..etc.. The REAL Dope is from who many of us consider the best guy here, so I know that is solid PLUS I had this same stash before I started the med.

Still following? So, I decided to try another stash that I shelved because it cooks up sort of blackish and has strange super noddy/tired legs.

<FUCKING BOOOOOOOM!!!> The rush nearly knocked me over! It wasn't reduced at all from what I can tell. Now, fentanyl and it's analogs I assume, are NOT metabolized by CPY2D6. Parts of it's metabolism are not understood so well, but a different enzyme P45034A is definitely in the mix.

I'm going to continue conducting research within this important scientific study (aka getting high every day, heh) but it seems likely to me that there is somethig in that dope getting me high that is NOT H..

Any science minds in here want to offer some insight? We'd love to learn! Oh, and for some reading fun, goto your favorite search engine and type in Addiction Inbox The CYP2D6 Factor.

At this time, I don't feel comfortable naming the vendor but will continue testing. He likely has a different batch by now anyway. Plus, I bet many of you have figured out who both of them are by now..

Genetic testing rocks


Comments


[5 Points] buticanfeelyours:

No shade, but you guys LOVE your smack.


[1 Points] durgsrbad:

Nothing to add, just commenting so I can check later. Love this stuff, and I hope there's a few worthwhile replies to nut it out.

Got a feeling I know who the shelved stuff came from, but some confirmation wouldn't go astray. He's had stuff for a while that cooks up a little odd, but folk swear by it. Left wondering if we're not actually dealing with analogues, but have hit the breakpoint where purity is kicking down a few doors.


[1 Points] throwahooawayyfoe:

A+ on the sensational headline?


[1 Points] ILikeToThrowAwaaayy:

I know a little on this subject, but I couldn't give you a definitive answer.

You are probably known as a poor metaboliser, which means it takes you longer to get the same work done than for other people. This means that if you have a regular drug schedule, you will accumulate more drug in your system than the average person - since you aren't metabolising it out of your system.

Now, if you have a pro-drug, which needs to be metabolised first before it is active, then you wont feel much from what you have taken, although it may creep up and last longer.

In this case, heroin is biologically inactive. The is the acetylated form of morphine, which makes it more lipophillic and thus it enters cells easier. Heroin is stronger than morphine because more of it can get into the brain, where it is then metabolised into morphine. However, if you metabolise poorly, this effect wont be observed. Fentanyl, as far as I know, is active in its given form, so you don't need to metabolise it to feel it. Additionally, fentanyl may have longer effects because you don't get rid of it fast enough.

By no means a definitive answer and doesn't look at any mechanisms in specific, but I imagine this is the logic in the answer.


[1 Points] Theeconomist1:

I had a DNA test done that tested these genes as well. Luckily I'm a normal processor of opiates. I found that I am a very poor processor of Valium and Xanax though. It was a pretty cool test, gave a nice printout of 100 drugs and how well or poorly I metabolize each one.